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Antiviral Agents

Impact of Drug Resistance-Associated Amino Acid Changes in HIV-1 Subtype C on Susceptibility to Newer Nonnucleoside Reverse Transcriptase Inhibitors

Adriaan E. Basson, Soo-Yon Rhee, Chris M. Parry, Ziad El-Khatib, Salome Charalambous, Tulio De Oliveira, Deenan Pillay, Christopher Hoffmann, David Katzenstein, Robert W. Shafer, Lynn Morris
Adriaan E. Basson
aCentre for HIV and STIs, National Institute for Communicable Diseases (NICD), part of the National Health Laboratory Service (NHLS), Johannesburg, South Africa
bUniversity of the Witwatersrand, Johannesburg, South Africa
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Soo-Yon Rhee
cDivision of Infectious Diseases, Stanford University Medical Center, Stanford, California, USA
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Chris M. Parry
dAntiviral Unit Virus Reference Department, Health Protection Agency (HPA), London, United Kingdom
eMRC/UCL Center for Medical Molecular Virology, UCL, London, United Kingdom
fMRC/UVRI Research Unit on AIDS, Uganda Virus Research Institute, Entebbe, Uganda
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Ziad El-Khatib
aCentre for HIV and STIs, National Institute for Communicable Diseases (NICD), part of the National Health Laboratory Service (NHLS), Johannesburg, South Africa
gDepartment of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
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Salome Charalambous
hThe Aurum Institute, Johannesburg, South Africa
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Tulio De Oliveira
iAfrica Centre for Health and Population Studies, University of KwaZulu-Natal, Mtubatuba, South Africa
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Deenan Pillay
dAntiviral Unit Virus Reference Department, Health Protection Agency (HPA), London, United Kingdom
eMRC/UCL Center for Medical Molecular Virology, UCL, London, United Kingdom
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Christopher Hoffmann
hThe Aurum Institute, Johannesburg, South Africa
jJohns Hopkins University, Center for TB Research, School of Medicine, Baltimore, Maryland, USA
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David Katzenstein
cDivision of Infectious Diseases, Stanford University Medical Center, Stanford, California, USA
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Robert W. Shafer
cDivision of Infectious Diseases, Stanford University Medical Center, Stanford, California, USA
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Lynn Morris
aCentre for HIV and STIs, National Institute for Communicable Diseases (NICD), part of the National Health Laboratory Service (NHLS), Johannesburg, South Africa
bUniversity of the Witwatersrand, Johannesburg, South Africa
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DOI: 10.1128/AAC.04215-14
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Article Information

DOI 
https://doi.org/10.1128/AAC.04215-14
PubMed 
25421485

Published By 
American Society for Microbiology Journals
History 
  • Received September 3, 2014
  • Returned for modification October 6, 2014
  • Accepted November 21, 2014
  • Published online January 27, 2015.

Copyright & Usage 
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (November 24, 2014).
  • You are viewing the most recent version of this article.

Author Information

  1. Adriaan E. Bassona,b,
  2. Soo-Yon Rheec,
  3. Chris M. Parryd,e,f,
  4. Ziad El-Khatiba,g,
  5. Salome Charalamboush,
  6. Tulio De Oliveirai,
  7. Deenan Pillayd,e,
  8. Christopher Hoffmannh,j,
  9. David Katzensteinc,
  10. Robert W. Shaferc and
  11. Lynn Morrisa,b
  1. aCentre for HIV and STIs, National Institute for Communicable Diseases (NICD), part of the National Health Laboratory Service (NHLS), Johannesburg, South Africa
  2. bUniversity of the Witwatersrand, Johannesburg, South Africa
  3. cDivision of Infectious Diseases, Stanford University Medical Center, Stanford, California, USA
  4. dAntiviral Unit Virus Reference Department, Health Protection Agency (HPA), London, United Kingdom
  5. eMRC/UCL Center for Medical Molecular Virology, UCL, London, United Kingdom
  6. fMRC/UVRI Research Unit on AIDS, Uganda Virus Research Institute, Entebbe, Uganda
  7. gDepartment of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
  8. hThe Aurum Institute, Johannesburg, South Africa
  9. iAfrica Centre for Health and Population Studies, University of KwaZulu-Natal, Mtubatuba, South Africa
  10. jJohns Hopkins University, Center for TB Research, School of Medicine, Baltimore, Maryland, USA
  • Address correspondence to Lynn Morris, lynnm{at}nicd.ac.za.
  • Citation Basson AE, Rhee S-Y, Parry CM, El-Khatib Z, Charalambous S, De Oliveira T, Pillay D, Hoffmann C, Katzenstein D, Shafer RW, Morris L. 2015. Impact of drug resistance-associated amino acid changes in HIV-1 subtype C on susceptibility to newer nonnucleoside reverse transcriptase inhibitors. Antimicrob Agents Chemother 59:960–971. doi:10.1128/AAC.04215-14.

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Impact of Drug Resistance-Associated Amino Acid Changes in HIV-1 Subtype C on Susceptibility to Newer Nonnucleoside Reverse Transcriptase Inhibitors
Adriaan E. Basson, Soo-Yon Rhee, Chris M. Parry, Ziad El-Khatib, Salome Charalambous, Tulio De Oliveira, Deenan Pillay, Christopher Hoffmann, David Katzenstein, Robert W. Shafer, Lynn Morris
Antimicrobial Agents and Chemotherapy Jan 2015, 59 (2) 960-971; DOI: 10.1128/AAC.04215-14

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Impact of Drug Resistance-Associated Amino Acid Changes in HIV-1 Subtype C on Susceptibility to Newer Nonnucleoside Reverse Transcriptase Inhibitors
Adriaan E. Basson, Soo-Yon Rhee, Chris M. Parry, Ziad El-Khatib, Salome Charalambous, Tulio De Oliveira, Deenan Pillay, Christopher Hoffmann, David Katzenstein, Robert W. Shafer, Lynn Morris
Antimicrobial Agents and Chemotherapy Jan 2015, 59 (2) 960-971; DOI: 10.1128/AAC.04215-14
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