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Experimental Therapeutics

Identification of a New Amide-Containing Thiazole as a Drug Candidate for Treatment of Chagas' Disease

Guzmán Álvarez, Javier Varela, Eugenia Cruces, Marcelo Fernández, Martín Gabay, Sandra M. Leal, Patricia Escobar, Luis Sanabria, Elva Serna, Susana Torres, Susy J. Figueredo Thiel, Gloria Yaluff, Ninfa I. Vera de Bilbao, Hugo Cerecetto, Mercedes González
Guzmán Álvarez
aGrupo de Química Medicinal, Laboratorio de Química Orgánica, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay
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Javier Varela
aGrupo de Química Medicinal, Laboratorio de Química Orgánica, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay
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Eugenia Cruces
aGrupo de Química Medicinal, Laboratorio de Química Orgánica, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay
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Marcelo Fernández
bLaboratorio de Experimentación Animal, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay
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Martín Gabay
aGrupo de Química Medicinal, Laboratorio de Química Orgánica, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay
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Sandra M. Leal
cCentro de Investigaciones de Enfermedades Tropicales, Departamento de Ciencias Básicas, Universidad Industrial de Santander, Bucaramanga, Colombia
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Patricia Escobar
cCentro de Investigaciones de Enfermedades Tropicales, Departamento de Ciencias Básicas, Universidad Industrial de Santander, Bucaramanga, Colombia
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Luis Sanabria
dDepartamento de Medicina Tropical, Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción, Asunción, Paraguay
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Elva Serna
dDepartamento de Medicina Tropical, Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción, Asunción, Paraguay
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Susana Torres
dDepartamento de Medicina Tropical, Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción, Asunción, Paraguay
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Susy J. Figueredo Thiel
eDepartamento de Anatomía Patológica, Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción, Asunción, Paraguay
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Gloria Yaluff
dDepartamento de Medicina Tropical, Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción, Asunción, Paraguay
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Ninfa I. Vera de Bilbao
dDepartamento de Medicina Tropical, Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción, Asunción, Paraguay
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Hugo Cerecetto
aGrupo de Química Medicinal, Laboratorio de Química Orgánica, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay
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Mercedes González
aGrupo de Química Medicinal, Laboratorio de Química Orgánica, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay
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DOI: 10.1128/AAC.03814-14
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Article Information

DOI 
https://doi.org/10.1128/AAC.03814-14
PubMed 
25512408

Published By 
American Society for Microbiology Journals
History 
  • Received July 6, 2014
  • Returned for modification August 5, 2014
  • Accepted November 28, 2014
  • Published online February 11, 2015.

Copyright & Usage 
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (December 15, 2014).
  • You are viewing the most recent version of this article.

Author Information

  1. Guzmán Álvareza,
  2. Javier Varelaa,
  3. Eugenia Crucesa,
  4. Marcelo Fernándezb,
  5. Martín Gabaya,
  6. Sandra M. Lealc,
  7. Patricia Escobarc,
  8. Luis Sanabriad,
  9. Elva Sernad,
  10. Susana Torresd,
  11. Susy J. Figueredo Thiele,
  12. Gloria Yaluffd,
  13. Ninfa I. Vera de Bilbaod,
  14. Hugo Cerecettoa and
  15. Mercedes Gonzáleza
  1. aGrupo de Química Medicinal, Laboratorio de Química Orgánica, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay
  2. bLaboratorio de Experimentación Animal, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay
  3. cCentro de Investigaciones de Enfermedades Tropicales, Departamento de Ciencias Básicas, Universidad Industrial de Santander, Bucaramanga, Colombia
  4. dDepartamento de Medicina Tropical, Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción, Asunción, Paraguay
  5. eDepartamento de Anatomía Patológica, Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción, Asunción, Paraguay
  • Address correspondence to Hugo Cerecetto, hcerecetto{at}cin.edu.uy, or Mercedes González, megonzal{at}fq.edu.uy.
  • Citation Álvarez G, Varela J, Cruces E, Fernández M, Gabay M, Leal SM, Escobar P, Sanabria L, Serna E, Torres S, Figueredo Thiel SJ, Yaluff G, Vera de Bilbao NI, Cerecetto H, González M. 2015. Identification of a new amide-containing thiazole as a drug candidate for treatment of Chagas' disease. Antimicrob Agents Chemother 59:1398–1404. doi:10.1128/AAC.03814-14.

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Identification of a New Amide-Containing Thiazole as a Drug Candidate for Treatment of Chagas' Disease
Guzmán Álvarez, Javier Varela, Eugenia Cruces, Marcelo Fernández, Martín Gabay, Sandra M. Leal, Patricia Escobar, Luis Sanabria, Elva Serna, Susana Torres, Susy J. Figueredo Thiel, Gloria Yaluff, Ninfa I. Vera de Bilbao, Hugo Cerecetto, Mercedes González
Antimicrobial Agents and Chemotherapy Feb 2015, 59 (3) 1398-1404; DOI: 10.1128/AAC.03814-14

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Identification of a New Amide-Containing Thiazole as a Drug Candidate for Treatment of Chagas' Disease
Guzmán Álvarez, Javier Varela, Eugenia Cruces, Marcelo Fernández, Martín Gabay, Sandra M. Leal, Patricia Escobar, Luis Sanabria, Elva Serna, Susana Torres, Susy J. Figueredo Thiel, Gloria Yaluff, Ninfa I. Vera de Bilbao, Hugo Cerecetto, Mercedes González
Antimicrobial Agents and Chemotherapy Feb 2015, 59 (3) 1398-1404; DOI: 10.1128/AAC.03814-14
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