DOI: 10.1128/AAC.04110-14
Article Figures & Data
Figures
- FIG 1
Twenty-four-hour time-kill studies.
- FIG 2
Increased intracellular minocycline concentration with polymyxin B. The value for the minocycline-only group was fixed at 1 (reference) (shaded bars).
- FIG 3
Tissue burdens at 24 h for various clinical strains *, P < 0.05 for the combination group compared to either monotherapy group.
- FIG 4
Survival rates of animals infected with AB 1261 (P < 0.001 for treatment groups compared to placebo group).
Tables
- TABLE 1
Characteristics of the bacterial isolates used
Isolate Source MIC (μg/ml) Resistance mechanism(s) Minocyline Minocyline + PAβNa Polymyxin B AB BAA 747 Laboratory 0.25 0.125 1 Reference adeB expression AB 7283 Clinical 0.5 0.125 1 Moderate overexpressionb of adeB AB 1261 Clinical 1 0.125 2 Moderate overexpression of adeB AB 7416 Clinical 16 2 1 tetB, moderate overexpression of adeB
