Article Figures & Data
Figures
- FIG 1
Effects of A. baumannii on cytokine and LPC production in the murine peritoneal sepsis model. (A) Levels of TNF-α, IL-6, IL-1β, and IL-10 were determined from 0 to 12 h, using the sera of mice inoculated with A. baumannii ATCC 17978. (B) LPC production was determined from 0 to 24 h, using the sera of control mice and mice inoculated with A. baumannii ATCC 17978. (C) Patterns of LPC and cytokine production in the murine model of peritoneal sepsis caused by A. baumannii. *, P < 0.05 for comparison of control group and mice infected with ATCC 17978.
- FIG 2
Serum LPC pharmacokinetics. LPC was administered to mice i.p. at a dose of 25 mg/kg, and the serum LPC concentrations were analyzed for 120 min.
- FIG 3
Effects of LPC on cytokine production in a murine peritoneal sepsis model of A. baumannii infection. Mice received preemptive therapy with LPC and were then inoculated with ATCC 17978. The levels of TNF-α, IL-6, IL-1β, and IL-10 in the serum were determined from 0 to 12 h. Representative results are shown, and the data are presented as means ± SEM. *, P < 0.05 for comparison of ATCC 17978 and LPC.
Tables
- TABLE 1
Therapeutic effect of LPC in murine peritoneal sepsis and pneumonia models of A. baumannii ATCC 17978 infection
Infection model Treatment group (n) Survival (%) Log10 CFU/g spleen (mean ± SEM) Log10 CFU/g lung (mean ± SEM) % sterile blood cultures Pneumonia Control (10) 0 ND 9.45 ± 0.4 20 25 mg/kg LPC (15) 68.75a ND 6.96 ± 0.67a 44 Peritoneal sepsis Control (13) 0 9.72 ± 0.09 8.74 ± 0.18 0 25 mg/kg LPC (15) 40 5.82 ± 0.76a 6.37 ± 0.77a 60a ↵a P < 0.05 with respect to the control group.
