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Mechanisms of Resistance

Impact of Ciprofloxacin and Clindamycin Administration on Gram-Negative Bacteria Isolated from Healthy Volunteers and Characterization of the Resistance Genes They Harbor

Roderick M. Card, Muriel Mafura, Theresa Hunt, Miranda Kirchner, Jan Weile, Mamun-Ur Rashid, Andrej Weintraub, Carl Erik Nord, Muna F. Anjum
Roderick M. Card
aDepartment of Bacteriology, Animal and Plant Health Agency, Addlestone, Surrey, United Kingdom
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Muriel Mafura
aDepartment of Bacteriology, Animal and Plant Health Agency, Addlestone, Surrey, United Kingdom
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Theresa Hunt
aDepartment of Bacteriology, Animal and Plant Health Agency, Addlestone, Surrey, United Kingdom
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Miranda Kirchner
aDepartment of Bacteriology, Animal and Plant Health Agency, Addlestone, Surrey, United Kingdom
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Jan Weile
bInstitute for Laboratory and Transfusion Medicine at the Heart and Diabetes Centre, University Hospital of the Ruhr University, Bochum, Germany
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Mamun-Ur Rashid
cDepartment of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
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Andrej Weintraub
cDepartment of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
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Carl Erik Nord
cDepartment of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
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Muna F. Anjum
aDepartment of Bacteriology, Animal and Plant Health Agency, Addlestone, Surrey, United Kingdom
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DOI: 10.1128/AAC.00068-15
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    FIG 1

    Impact of antibiotic administration on the geometric mean CFU of fecal E. coli (a), saliva Leptotrichia spp. (b), saliva Veillonella spp. (c), and saliva Veillonella spp. (d) on ciprofloxacin-containing plates and of fecal Bacteroides spp. (e).

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    FIG 2

    PFGE and antibiotic resistance gene profile of E. coli isolates recovered from the feces of three volunteers.

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      Supplemental File S1 and Tables S1 to S5.

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Impact of Ciprofloxacin and Clindamycin Administration on Gram-Negative Bacteria Isolated from Healthy Volunteers and Characterization of the Resistance Genes They Harbor
Roderick M. Card, Muriel Mafura, Theresa Hunt, Miranda Kirchner, Jan Weile, Mamun-Ur Rashid, Andrej Weintraub, Carl Erik Nord, Muna F. Anjum
Antimicrobial Agents and Chemotherapy Jul 2015, 59 (8) 4410-4416; DOI: 10.1128/AAC.00068-15

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Impact of Ciprofloxacin and Clindamycin Administration on Gram-Negative Bacteria Isolated from Healthy Volunteers and Characterization of the Resistance Genes They Harbor
Roderick M. Card, Muriel Mafura, Theresa Hunt, Miranda Kirchner, Jan Weile, Mamun-Ur Rashid, Andrej Weintraub, Carl Erik Nord, Muna F. Anjum
Antimicrobial Agents and Chemotherapy Jul 2015, 59 (8) 4410-4416; DOI: 10.1128/AAC.00068-15
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