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Pharmacology

Validation and Pharmacokinetic Application of a High-Performance Liquid Chromatographic Technique for Determining the Concentrations of Amodiaquine and Its Metabolite in Plasma of Patients Treated with Oral Fixed-Dose Amodiaquine-Artesunate Combination in Areas of Malaria Endemicity

Olumuyiwa N. Adedeji, Oluseye O. Bolaji, Catherine O. Falade, Odusoga A. Osonuga, Olusegun G. Ademowo
Olumuyiwa N. Adedeji
aDepartment of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria
cInstitute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria
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Oluseye O. Bolaji
bDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria
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Catherine O. Falade
aDepartment of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria
cInstitute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria
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Odusoga A. Osonuga
dOlabisi Onabanjo University, Department of Pharmacology, College of Health Sciences, Sagamu, Nigeria
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Olusegun G. Ademowo
aDepartment of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria
cInstitute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria
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DOI: 10.1128/AAC.04957-14
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Article Information

DOI 
https://doi.org/10.1128/AAC.04957-14
PubMed 
25896711

Published By 
American Society for Microbiology Journals
History 
  • Received December 3, 2014
  • Returned for modification January 31, 2015
  • Accepted April 5, 2015
  • Published online August 14, 2015.

Copyright & Usage 
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (April 20, 2015).
  • You are viewing the most recent version of this article.

Author Information

  1. Olumuyiwa N. Adedejia,c,
  2. Oluseye O. Bolajib,
  3. Catherine O. Faladea,c,
  4. Odusoga A. Osonugad and
  5. Olusegun G. Ademowoa,c
  1. aDepartment of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria
  2. bDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria
  3. cInstitute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria
  4. dOlabisi Onabanjo University, Department of Pharmacology, College of Health Sciences, Sagamu, Nigeria
  • Address correspondence to Olusegun G. Ademowo, ademowo_g{at}yahoo.com.
  • Citation Adedeji ON, Bolaji OO, Falade CO, Osonuga OA, Ademowo OG. 2015. Validation and pharmacokinetic application of a high-performance liquid chromatographic technique for determining the concentrations of amodiaquine and its metabolite in plasma of patients treated with oral fixed-dose amodiaquine-artesunate combination in areas of malaria endemicity. Antimicrob Agents Chemother 59:5114–5122. doi:10.1128/AAC.04957-14.

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Validation and Pharmacokinetic Application of a High-Performance Liquid Chromatographic Technique for Determining the Concentrations of Amodiaquine and Its Metabolite in Plasma of Patients Treated with Oral Fixed-Dose Amodiaquine-Artesunate Combination in Areas of Malaria Endemicity
Olumuyiwa N. Adedeji, Oluseye O. Bolaji, Catherine O. Falade, Odusoga A. Osonuga, Olusegun G. Ademowo
Antimicrobial Agents and Chemotherapy Aug 2015, 59 (9) 5114-5122; DOI: 10.1128/AAC.04957-14

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Validation and Pharmacokinetic Application of a High-Performance Liquid Chromatographic Technique for Determining the Concentrations of Amodiaquine and Its Metabolite in Plasma of Patients Treated with Oral Fixed-Dose Amodiaquine-Artesunate Combination in Areas of Malaria Endemicity
Olumuyiwa N. Adedeji, Oluseye O. Bolaji, Catherine O. Falade, Odusoga A. Osonuga, Olusegun G. Ademowo
Antimicrobial Agents and Chemotherapy Aug 2015, 59 (9) 5114-5122; DOI: 10.1128/AAC.04957-14
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