Antimicrobial Agents and Chemotherapy: 60 (1)

January 1, 2016; Volume 60,Issue 1

Challenging Clinical Cases in Antimicrobial Resistance

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Challenging Clinical Case in Antimicrobial Resistance
Clinafloxacin for Treatment of Burkholderia cenocepacia Infection in a Cystic Fibrosis Patient
Akshu Balwan, David P. Nicolau, Minkey Wungwattana, Jonathan B. Zuckerman, Valerie Waters

Chemistry; Biosynthesis

Chemistry; Biosynthesis
Synthesis, Bioactivity Evaluation, and Toxicity Assessment of Novel Salicylanilide Ester Derivatives as Cercaricides against Schistosoma japonicum and Molluscicides against Oncomelania hupensis
Weisi Wang, Zhiqiang Qin, Dan Zhu, Yufen Wei, Shizhu Li, Liping Duan

Mechanisms of Action: Physiological Effects

Mechanisms of Action: Physiological Effects
Impact of a Cross-Kingdom Signaling Molecule of Candida albicans on Acinetobacter baumannii Physiology
Xenia Kostoulias, Gerald L. Murray, Gustavo M. Cerqueira, Jason B. Kong, Farkad Bantun, Eleftherios Mylonakis, Chen Ai Khoo, Anton Y. Peleg
Mechanisms of Action: Physiological Effects
Gallium Potentiates the Antibacterial Effect of Gentamicin against Francisella tularensis
Helena Lindgren, Anders Sjöstedt
Mechanisms of Action: Physiological Effects
Cardiac Effects of Echinocandins in Endotoxemic Rats
Christian Koch, Matthias Wolff, Michael Henrich, Markus A. Weigand, Christoph Lichtenstern, Florian Uhle
Mechanisms of Action: Physiological Effects
Penicillin Binding Protein 1 Is Important in the Compensatory Response of Staphylococcus aureus to Daptomycin-Induced Membrane Damage and Is a Potential Target for β-Lactam–Daptomycin Synergy
Andrew D. Berti, Erin Theisen, John-Demian Sauer, Poochit Nonejuie, Joshua Olson, Joseph Pogliano, George Sakoulas, Victor Nizet, Richard A. Proctor, Warren E. Rose
Mechanisms of Action: Physiological Effects
Interactions of OP0595, a Novel Triple-Action Diazabicyclooctane, with β-Lactams against OP0595-Resistant Enterobacteriaceae Mutants
David M. Livermore, Marina Warner, Shazad Mushtaq, Neil Woodford

Mechanisms of Resistance

Mechanisms of Resistance
Cooccurrence of Multiple AmpC β-Lactamases in Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis in Tunisia
Thouraya Chérif, Mabrouka Saidani, Dominique Decré, Ilhem Boutiba-Ben Boubaker, Guillaume Arlet
Mechanisms of Resistance
Active-Site Plasticity Is Essential to Carbapenem Hydrolysis by OXA-58 Class D β-Lactamase of Acinetobacter baumannii
Shivendra Pratap, Madhusudhanarao Katiki, Preet Gill, Pravindra Kumar, Dasantila Golemi-Kotra
Mechanisms of Resistance
Genomic Characteristics of NDM-Producing Enterobacteriaceae Isolates in Australia and Their bla_NDM Genetic Contexts
Alexander M. Wailan, David L. Paterson, Karina Kennedy, Paul R. Ingram, Evan Bursle, Hanna E. Sidjabat
Open Access

Mechanisms of Resistance
Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers
Jürgen Brem, Sander S. van Berkel, David Zollman, Sook Y. Lee, Opher Gileadi, Peter J. McHugh, Timothy R. Walsh, Michael A. McDonough, Christopher J. Schofield
Mechanisms of Resistance
The Soil Microbiota Harbors a Diversity of Carbapenem-Hydrolyzing β-Lactamases of Potential Clinical Relevance
Dereje Dadi Gudeta, Valeria Bortolaia, Greg Amos, Elizabeth M. H. Wellington, Kristian K. Brandt, Laurent Poirel, Jesper Boye Nielsen, Henrik Westh, Luca Guardabassi
Mechanisms of Resistance
Molecular Characterization of Carbapenem-Nonsusceptible Enterobacterial Isolates Collected during a Prospective Interregional Survey in France and Susceptibility to the Novel Ceftazidime-Avibactam and Aztreonam-Avibactam Combinations
Hervé Dupont, Olivier Gaillot, Anne-Sophie Goetgheluck, Claire Plassart, Jean-Philippe Emond, Marion Lecuru, Nicolas Gaillard, Sarah Derdouri, Baptiste Lemaire, Marion Girard de Courtilles, Vincent Cattoir, Hedi Mammeri
Mechanisms of Resistance
Activity of Isavuconazole and Other Azoles against Candida Clinical Isolates and Yeast Model Systems with Known Azole Resistance Mechanisms
Dominique Sanglard, Alix T. Coste
Mechanisms of Resistance
Within-Host Selection of Drug Resistance in a Mouse Model of Repeated Incomplete Malaria Treatment: Comparison between Atovaquone and Pyrimethamine
Suci Nuralitha, Josephine E. Siregar, Din Syafruddin, Jessica Roelands, Jan Verhoef, Andy I. M. Hoepelman, Sangkot Marzuki
Mechanisms of Resistance
Role of Non-Active-Site Residue Trp-93 in the Function and Stability of New Delhi Metallo-β-Lactamase 1
Asad U. Khan, M. Tabish Rehman
Open Access

Mechanisms of Resistance
Expression of Plasmodium vivax crt-o Is Related to Parasite Stage but Not Ex Vivo Chloroquine Susceptibility
Zuleima Pava, Irene Handayuni, Grennady Wirjanata, Sheren To, Leily Trianty, Rintis Noviyanti, Jeanne Rini Poespoprodjo, Sarah Auburn, Ric N. Price, Jutta Marfurt
Mechanisms of Resistance
In Vitro Activity of β-Lactams in Combination with β-Lactamase Inhibitors against Multidrug-Resistant Mycobacterium tuberculosis Isolates
Dan Zhang, Yufeng Wang, Jie Lu, Yu Pang
Mechanisms of Resistance
Reactive Oxygen Species Contribute to the Bactericidal Effects of the Fluoroquinolone Moxifloxacin in Streptococcus pneumoniae
M. J. Ferrándiz, A. J. Martín-Galiano, C. Arnanz, T. Zimmerman, A. G. de la Campa
Mechanisms of Resistance
Carriage of Enterobacteria Producing Extended-Spectrum β-Lactamases and Composition of the Gut Microbiota in an Amerindian Community
María José Gosalbes, Jorge F. Vázquez-Castellanos, Cécile Angebault, Paul-Louis Woerther, Etienne Ruppé, María Loreto Ferrús, Amparo Latorre, Antoine Andremont, Andrés Moya
Mechanisms of Resistance
Plasmid-Mediated OqxAB Is an Important Mechanism for Nitrofurantoin Resistance in Escherichia coli
Pak-Leung Ho, Ka-Ying Ng, Wai-U Lo, Pierra Y. Law, Eileen Ling-Yi Lai, Ya Wang, Kin-Hung Chow
Mechanisms of Resistance
Extracellular DNA Acidifies Biofilms and Induces Aminoglycoside Resistance in Pseudomonas aeruginosa
Mike Wilton, Laetitia Charron-Mazenod, Richard Moore, Shawn Lewenza
Mechanisms of Resistance
Preservation of Acquired Colistin Resistance in Gram-Negative Bacteria
Ji-Young Lee, Myung-Jin Choi, Hyeon Jin Choi, Kwan Soo Ko
Mechanisms of Resistance
Novobiocin Inhibits the Antimicrobial Resistance Acquired through DNA Damage-Induced Mutagenesis in Acinetobacter baumannii
Luis M. Jara, María Pérez-Varela, Jordi Corral, Marta Arch, Pilar Cortés, Germán Bou, Jesús Aranda, Jordi Barbé
Mechanisms of Resistance
Double Copies of bla_KPC-3::Tn4401a on an IncX3 Plasmid in Klebsiella pneumoniae Successful Clone ST512 from Italy
Daniela Fortini, Laura Villa, Claudia Feudi, João Pires, Celestino Bonura, Caterina Mammina, Andrea Endimiani, Alessandra Carattoli
Mechanisms of Resistance
Complete Sequences of IncU Plasmids Harboring Quinolone Resistance Genes qnrS2 and aac(6′)-Ib-cr in Aeromonas spp. from Ornamental Fish
Hana Dobiasova, Petra Videnska, Monika Dolejska
Mechanisms of Resistance
Characterization of a cfr-Carrying Plasmid from Porcine Escherichia coli That Closely Resembles Plasmid pEA3 from the Plant Pathogen Erwinia amylovora
Rongmin Zhang, Bin Sun, Yang Wang, Lei Lei, Stefan Schwarz, Congming Wu
Mechanisms of Resistance
Acquired Flucytosine Resistance during Combination Therapy with Caspofungin and Flucytosine for Candida glabrata Cystitis
Caroline Charlier, Carine El Sissy, Sophie Bachelier-Bassi, Anne Scemla, Gilles Quesne, Emilie Sitterlé, Christophe Legendre, Olivier Lortholary, Marie-Elisabeth Bougnoux
Mechanisms of Resistance
fosI Is a New Integron-Associated Gene Cassette Encoding Reduced Susceptibility to Fosfomycin
Karla de Oliveira Pelegrino, Juliana Coutinho Campos, Suely Carlos Ferreira Sampaio, Karina Lezirovitz, Bruna Mara Seco, Mayne de Oliveira Pereira, Darlan Augusto da Costa Rocha, Thomas Jové, Antonio Carlos Nicodemo, Jorge Luiz Mello Sampaio
Mechanisms of Resistance
Heterologous Expression and Functional Characterization of the Exogenously Acquired Aminoglycoside Resistance Methyltransferases RmtD, RmtD2, and RmtG
Laís L. Corrêa, Marta A. Witek, Natalia Zelinskaya, Renata C. Picão, Graeme L. Conn
Mechanisms of Resistance
Genome Analysis of Kingella kingae Strain KWG1 Reveals How a β-Lactamase Gene Inserted in the Chromosome of This Species
Philippe Bidet, Romain Basmaci, Julien Guglielmini, Catherine Doit, Christelle Jost, André Birgy, Stéphane Bonacorsi
Mechanisms of Resistance
Emergence of Carbapenem-Resistant Serotype K1 Hypervirulent Klebsiella pneumoniae Strains in China
Rong Zhang, Dachuan Lin, Edward Wai-chi Chan, Danxia Gu, Gong-Xiang Chen, Sheng Chen

Susceptibility

Susceptibility
Microbicides Alter the Expression and Function of RND-Type Efflux Pump AdeABC in Biofilm-Associated Cells of Acinetobacter baumannii Clinical Isolates
Suvarna Krishnamoorthy, Bhavikkumar P. Shah, Hiu Ham Lee, Luis R. Martinez
Susceptibility
Escherichia coli Overexpressing a Baeyer-Villiger Monooxygenase from Acinetobacter radioresistens Becomes Resistant to Imipenem
Daniela Minerdi, Ivan Zgrablic, Silvia Castrignanò, Gianluca Catucci, Claudio Medana, Maria Elena Terlizzi, Giorgio Gribaudo, Gianfranco Gilardi, Sheila J. Sadeghi
Susceptibility
In Vitro and In Vivo Antimicrobial Activities of Minocycline in Combination with Azithromycin, Clarithromycin, or Tigecycline against Pythium insidiosum
Francielli P. K. Jesus, Érico S. Loreto, Laerte Ferreiro, Sydney H. Alves, David Driemeier, Suyene O. Souza, Raqueli T. França, Sonia T. A. Lopes, Maiara B. Pilotto, Aline Ludwig, Maria I. Azevedo, Tatiana C. Ribeiro, Juliana S. M. Tondolo, Janio M. Santurio
Susceptibility
Antimicrobial Susceptibilities of Aerobic and Facultative Gram-Negative Bacilli from Intra-abdominal Infections in Patients from Seven Regions in China in 2012 and 2013
Hui Zhang, Qiwen Yang, Kang Liao, Yuxing Ni, Yunsong Yu, Bijie Hu, Ziyong Sun, Wenxiang Huang, Yong Wang, Anhua Wu, Xianju Feng, Yanping Luo, Zhidong Hu, Yunzhuo Chu, Shulan Chen, Bin Cao, Jianrong Su, Bingdong Gui, Qiong Duan, Shufang Zhang, Haifeng Shao, Haishen Kong, Robert E. Badal, Yingchun Xu
Susceptibility
In Vitro Activity of Ceftaroline against Staphylococcus aureus Isolated in 2012 from Asia-Pacific Countries as Part of the AWARE Surveillance Program
Douglas J. Biedenbach, Richard A. Alm, Sushmita D. Lahiri, Edina Reiszner, Daryl J. Hoban, Daniel F. Sahm, Samuel K. Bouchillon, Jane E. Ambler
Susceptibility
Activity of Tobramycin against Cystic Fibrosis Isolates of Burkholderia cepacia Complex Grown as Biofilms
Sarah Kennedy, Trevor Beaudoin, Yvonne C. W. Yau, Emma Caraher, James E. A. Zlosnik, David P. Speert, John J. LiPuma, Elizabeth Tullis, Valerie Waters
Open Access

Susceptibility
Type III Secretion-Dependent Sensitivity of Escherichia coli O157 to Specific Ketolides
Romina J. Fernandez-Brando, Nao Yamaguchi, Amin Tahoun, Sean P. McAteer, Trudi Gillespie, Dai Wang, Sally A. Argyle, Marina S. Palermo, David L. Gally
Susceptibility
Multidrug-Resistant Neisseria gonorrhoeae Isolates from Nanjing, China, Are Sensitive to Killing by a Novel DNA Gyrase Inhibitor, ETX0914 (AZD0914)
Xiao-Hong Su, Bao-Xi Wang, Wen-Jing Le, Yu-Rong Liu, Chuan Wan, Sai Li, Richard A. Alm, John P. Mueller, Peter A. Rice
Susceptibility
Effect of High-Dose Antimicrobials on Biofilm Growth of Achromobacter Species Isolated from Cystic Fibrosis Patients
Sean K. Tom, Yvonne C. W. Yau, Trevor Beaudoin, John J. LiPuma, Valerie Waters
Susceptibility
High Prevalence of Biocide Resistance Determinants in Staphylococcus aureus Isolates from Three African Countries
Teresa Conceição, Céline Coelho, Hermínia de Lencastre, Marta Aires-de-Sousa
Susceptibility
Azole Resistance in Aspergillus fumigatus Clinical Isolates from an Italian Culture Collection
Cristina Lazzarini, Maria Carmela Esposto, Anna Prigitano, Massimo Cogliati, Gabriella De Lorenzis, Anna Maria Tortorano
Open Access

Susceptibility
Susceptibility of Clostridium difficile Isolates of Varying Antimicrobial Resistance Phenotypes to SMT19969 and 11 Comparators
Jane Freeman, Jonathan Vernon, Richard Vickers, Mark H. Wilcox

Analytical Procedures

Analytical Procedures
Bioassay for Determining Voriconazole Serum Levels in Patients Receiving Combination Therapy with Echinocandins
Maria Siopi, Efthymios Neroutsos, Kalliopi Zisaki, Maria Gamaletsou, Maria Pirounaki, Panagiotis Tsirigotis, Nikolaos Sipsas, Aristides Dokoumetzidis, Evgenios Goussetis, Loukia Zerva, Georgia Valsami, Joseph Meletiadis

Antiviral Agents

Open Access

Antiviral Agents
Generation and Characterization of ALX-0171, a Potent Novel Therapeutic Nanobody for the Treatment of Respiratory Syncytial Virus Infection
Laurent Detalle, Thomas Stohr, Concepción Palomo, Pedro A. Piedra, Brian E. Gilbert, Vicente Mas, Andrena Millar, Ultan F. Power, Catelijne Stortelers, Koen Allosery, José A. Melero, Erik Depla
Open Access

Antiviral Agents
Drug Interactions with the Direct-Acting Antiviral Combination of Ombitasvir and Paritaprevir-Ritonavir
Prajakta S. Badri, Sandeep Dutta, Haoyu Wang, Thomas J. Podsadecki, Akshanth R. Polepally, Amit Khatri, Jiuhong Zha, Yi-Lin Chiu, Walid M. Awni, Rajeev M. Menon
Antiviral Agents
Antiretrovirals, Methamphetamine, and HIV-1 Envelope Protein gp120 Compromise Neuronal Energy Homeostasis in Association with Various Degrees of Synaptic and Neuritic Damage
Ana B. Sanchez, Giuseppe P. Varano, Cyrus M. de Rozieres, Ricky Maung, Irene C. Catalan, Cari C. Dowling, Natalia E. Sejbuk, Melanie M. Hoefer, Marcus Kaul
Antiviral Agents
Alkyl Amine Bevirimat Derivatives Are Potent and Broadly Active HIV-1 Maturation Inhibitors
Emiko Urano, Sherimay D. Ablan, Rebecca Mandt, Gary T. Pauly, Dina M. Sigano, Joel P. Schneider, David E. Martin, Theodore J. Nitz, Carl T. Wild, Eric O. Freed
Antiviral Agents
Modification of the Host Cell Lipid Metabolism Induced by Hypolipidemic Drugs Targeting the Acetyl Coenzyme A Carboxylase Impairs West Nile Virus Replication
Teresa Merino-Ramos, Ángela Vázquez-Calvo, Josefina Casas, Francisco Sobrino, Juan-Carlos Saiz, Miguel A. Martín-Acebes
Antiviral Agents
Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors
Gabriel Birkus, Rujuta A. Bam, Madeleine Willkom, Christian R. Frey, Luong Tsai, Kirsten M. Stray, Stephen R. Yant, Tomas Cihlar
Antiviral Agents
No Need for Lopinavir Dose Adjustment during Pregnancy: a Population Pharmacokinetic and Exposure-Response Analysis in Pregnant and Nonpregnant HIV-Infected Subjects
Ahmed Hamed Salem, Aksana Kaefer Jones, Marilia Santini-Oliveira, Graham P. Taylor, Kristine B. Patterson, Angela M. Nilius, Cheri Enders Klein
Antiviral Agents
Incompatible Natures of the HIV-1 Envelope in Resistance to the CCR5 Antagonist Cenicriviroc and to Neutralizing Antibodies
Takeo Kuwata, Ikumi Enomoto, Masanori Baba, Shuzo Matsushita
Antiviral Agents
Insights into the Molecular Mechanism of Polymerization and Nucleoside Reverse Transcriptase Inhibitor Incorporation by Human PrimPol
Andrea C. Mislak, Karen S. Anderson
Antiviral Agents
Identification of a Pyridoxine-Derived Small-Molecule Inhibitor Targeting Dengue Virus RNA-Dependent RNA Polymerase
Hong-Tao Xu, Susan P. Colby-Germinario, Said Hassounah, Peter K. Quashie, Yingshan Han, Maureen Oliveira, Brent R. Stranix, Mark A. Wainberg
Antiviral Agents
C5A Protects Macaques from Vaginal Simian-Human Immunodeficiency Virus Challenge
Ronald S. Veazey, Udayan Chatterji, Michael Bobardt, Kasi E. Russell-Lodrigue, Jian Li, Xiaolei Wang, Philippe A. Gallay

Epidemiology and Surveillance

Epidemiology and Surveillance
Antibiotic Resistance among Clinical Ureaplasma Isolates Recovered from Neonates in England and Wales between 2007 and 2013
Michael L. Beeton, Victoria J. Chalker, Lucy C. Jones, Nicola C. Maxwell, O. Brad Spiller
Epidemiology and Surveillance
Risk Factors and Outcomes for Bloodstream Infections Secondary to Clostridium difficile Infection
Marco Falcone, Alessandro Russo, Federica Iraci, Paolo Carfagna, Paola Goldoni, Vincenzo Vullo, Mario Venditti
Epidemiology and Surveillance
A Two-Year Surveillance in Five Colombian Tertiary Care Hospitals Reveals High Frequency of Non-CG258 Clones of Carbapenem-Resistant Klebsiella pneumoniae with Distinct Clinical Characteristics
Ana M. Ocampo, Liang Chen, Astrid V. Cienfuegos, Gustavo Roncancio, Kalyan D. Chavda, Barry N. Kreiswirth, J. Natalia Jiménez
Epidemiology and Surveillance
Quantitative Analysis of Single-Nucleotide Polymorphism for Rapid Detection of TR₃₄/L98H- and TR₄₆/Y121F/T289A-Positive Aspergillus fumigatus Isolates Obtained from Patients in Iran from 2010 to 2014
Faezeh Mohammadi, Seyed Jamal Hashemi, Jan Zoll, Willem J. G. Melchers, Haleh Rafati, Parvin Dehghan, Sasan Rezaie, Ali Tolooe, Yalda Tamadon, Henrich A. van der Lee, Paul E. Verweij, Seyedmojtaba Seyedmousavi
Epidemiology and Surveillance
Fluoroquinolone and Macrolide Exposure Predict Clostridium difficile Infection with the Highly Fluoroquinolone- and Macrolide-Resistant Epidemic C. difficile Strain BI/NAP1/027
Jeffrey T. Wieczorkiewicz, Bert K. Lopansri, Adam Cheknis, James R. Osmolski, David W. Hecht, Dale N. Gerding, Stuart Johnson
Epidemiology and Surveillance
Emergence of Mutations in the K13 Propeller Gene of Plasmodium falciparum Isolates from Dakar, Senegal, in 2013-2014
Agathe Boussaroque, Bécaye Fall, Marylin Madamet, Cheikhou Camara, Nicolas Benoit, Mansour Fall, Aminata Nakoulima, Pierre Dionne, Kadidiatou Ba Fall, Bakary Diatta, Yaya Diémé, Boubacar Wade, Bruno Pradines

Experimental Therapeutics

Open Access

Experimental Therapeutics
Biofilms of Pathogenic Nontuberculous Mycobacteria Targeted by New Therapeutic Approaches
Thet Tun Aung, Joey Kuok Hoong Yam, Shuimu Lin, Shuhaida Mohamed Salleh, Michael Givskov, Shouping Liu, Nyein Chan Lwin, Liang Yang, Roger W. Beuerman
Experimental Therapeutics
Benzo[b]quinolizinium Derivatives Have a Strong Antimalarial Activity and Inhibit Indoleamine Dioxygenase
Esther Jortzik, Kathleen Zocher, Antje Isernhagen, Boniface M. Mailu, Stefan Rahlfs, Giampietro Viola, Sergio Wittlin, Nicholas H. Hunt, Heiko Ihmels, Katja Becker
Experimental Therapeutics
Molecule Targeting Glucosyltransferase Inhibits Streptococcus mutans Biofilm Formation and Virulence
Zhi Ren, Tao Cui, Jumei Zeng, Lulu Chen, Wenling Zhang, Xin Xu, Lei Cheng, Mingyun Li, Jiyao Li, Xuedong Zhou, Yuqing Li
Experimental Therapeutics
In Vitro Pharmacodynamics of Human Simulated Exposures of Telavancin against Methicillin-Susceptible and -Resistant Staphylococcus aureus with and without Prior Vancomycin Exposure
Abrar K. Thabit, David P. Nicolau, Joseph L. Kuti
Experimental Therapeutics
Contribution of Oxazolidinones to the Efficacy of Novel Regimens Containing Bedaquiline and Pretomanid in a Mouse Model of Tuberculosis
Rokeya Tasneen, Fabrice Betoudji, Sandeep Tyagi, Si-Yang Li, Kathy Williams, Paul J. Converse, Véronique Dartois, Tian Yang, Carl M. Mendel, Khisimuzi E. Mdluli, Eric L. Nuermberger
Experimental Therapeutics
In Vivo Synergy of Amphotericin B plus Posaconazole in Murine Aspergillosis
Adela Martin-Vicente, Javier Capilla, Josep Guarro
Experimental Therapeutics
Cefotaxime and Amoxicillin-Clavulanate Synergism against Extended-Spectrum-β-Lactamase-Producing Escherichia coli in a Murine Model of Urinary Tract Infection
B. Rossi, J. F. Soubirou, F. Chau, L. Massias, S. Dion, R. Lepeule, B. Fantin, A. Lefort
Experimental Therapeutics
Fosfomycin plus β-Lactams as Synergistic Bactericidal Combinations for Experimental Endocarditis Due to Methicillin-Resistant and Glycopeptide-Intermediate Staphylococcus aureus
A. del Río, C. García-de-la-Mària, J. M. Entenza, O. Gasch, Y. Armero, D. Soy, C. A. Mestres, J. M. Pericás, C. Falces, S. Ninot, M. Almela, C. Cervera, J. M. Gatell, A. Moreno, P. Moreillon, F. Marco, J. M. Miró, the Hospital Clinic Experimental Endocarditis Study Group
Experimental Therapeutics
Antimicrobial Peptide CMA3 Derived from the CA-MA Hybrid Peptide: Antibacterial and Anti-inflammatory Activities with Low Cytotoxicity and Mechanism of Action in Escherichia coli
Jong-kook Lee, Chang Ho Seo, Tudor Luchian, Yoonkyung Park
Experimental Therapeutics
In Vitro Activity of ASP2397 against Aspergillus Isolates with or without Acquired Azole Resistance Mechanisms
Maiken Cavling Arendrup, Rasmus Hare Jensen, Manuel Cuenca-Estrella
Experimental Therapeutics
Inhibition of Calcium-Dependent Protein Kinase 1 (CDPK1) In Vitro by Pyrazolopyrimidine Derivatives Does Not Correlate with Sensitivity of Cryptosporidium parvum Growth in Cell Culture
Theresa B. Kuhlenschmidt, Florentine U. Rutaganira, Shaojun Long, Keliang Tang, Kevan M. Shokat, Mark S. Kuhlenschmidt, L. David Sibley
Experimental Therapeutics
Characterization of the Antimicrobial Peptide Penisin, a Class Ia Novel Lantibiotic from Paenibacillus sp. Strain A3
Piyush Baindara, Vasvi Chaudhry, Garima Mittal, Luciano M. Liao, Carolina O. Matos, Neeraj Khatri, Octavio L. Franco, Prabhu B. Patil, Suresh Korpole
Experimental Therapeutics
Development of an Intracellular Screen for New Compounds Able To Inhibit Mycobacterium tuberculosis Growth in Human Macrophages
Flavia Sorrentino, Ruben Gonzalez del Rio, Xingji Zheng, Jesus Presa Matilla, Pedro Torres Gomez, Maria Martinez Hoyos, Maria Esther Perez Herran, Alfonso Mendoza Losana, Yossef Av-Gay
Experimental Therapeutics
Efficacy of Extended-Interval Dosing of Micafungin Evaluated Using a Pharmacokinetic/Pharmacodynamic Study with Humanized Doses in Mice
A. Lepak, K. Marchillo, J. VanHecker, N. Azie, D. Andes

Clinical Therapeutics

Clinical Therapeutics
Large Cohort Study of Central Venous Catheter Thrombosis during Intravenous Antibiotic Therapy
Stéphanie Guillet, Valérie Zeller, Vincent Dubée, Françoise Ducroquet, Nicole Desplaces, Marie Hélène Horellou, Simon Marmor, Jean Marc Ziza
Clinical Therapeutics
Serum Levels of Antituberculosis Drugs and Their Effect on Tuberculosis Treatment Outcome
Jong Sun Park, Jae-Yeon Lee, Yeon Joo Lee, Se Joong Kim, Young-Jae Cho, Ho Il Yoon, Choon-Taek Lee, Junghan Song, Jae Ho Lee
Clinical Therapeutics
Nonimpact of Decolonization as an Adjunctive Measure to Contact Precautions for the Control of Methicillin-Resistant Staphylococcus aureus Transmission in Acute Care
Lance R. Peterson, Marc O. Wright, Jennifer L. Beaumont, Vanida Komutanon, Parul A. Patel, Donna M. Schora, Bryan H. Schmitt, Ari Robicsek
Clinical Therapeutics
Population Pharmacokinetics of Doripenem in Critically Ill Patients with Sepsis in a Malaysian Intensive Care Unit
Mohd H. Abdul-Aziz, Azrin N. Abd Rahman, Mohd-Basri Mat-Nor, Helmi Sulaiman, Steven C. Wallis, Jeffrey Lipman, Jason A. Roberts, Christine E. Staatz
Clinical Therapeutics
Case-Control Study of Telavancin as an Alternative Treatment for Gram-Positive Bloodstream Infections in Patients with Cancer
Anne-Marie Chaftari, Ray Hachem, Mary Jordan, Kumait Garoge, Zainab Al Hamal, Aline El Zakhem, George M. Viola, Bruno Granwehr, Victor Mulanovich, Andrew Gagel, Ruth Reitzel, Ammar Yousif, Ying Jiang, Issam Raad
Clinical Therapeutics
Neutropenia Associated with Long-Term Ceftaroline Use
Katherine W. LaVie, Scott W. Anderson, Hollis R. O'Neal, Todd W. Rice, Tatiana C. Saavedra, Catherine S. O'Neal
Clinical Therapeutics
Treatment Outcomes with Fluoroquinolone-Containing Regimens for Isoniazid-Resistant Pulmonary Tuberculosis
Hyun Lee, Byeong-Ho Jeong, Hye Yun Park, Kyeongman Jeon, Hee Jae Huh, Nam Yong Lee, Won-Jung Koh
Clinical Therapeutics
An Amphipathic Undecapeptide with All d-Amino Acids Shows Promising Activity against Colistin-Resistant Strains of Acinetobacter baumannii and a Dual Mode of Action
Alberto Oddo, Thomas T. Thomsen, Susanne Kjelstrup, Ciara Gorey, Henrik Franzyk, Niels Frimodt-Møller, Anders Løbner-Olesen, Paul R. Hansen
Clinical Therapeutics
The Clinically Tested Gardos Channel Inhibitor Senicapoc Exhibits Antimalarial Activity
Venée N. Tubman, Pedro Mejia, Boris E. Shmukler, Amy K. Bei, Seth L. Alper, James R. Mitchell, Carlo Brugnara, Manoj T. Duraisingh
Clinical Therapeutics
In Vitro Activity of Ceftolozane-Tazobactam against Anaerobic Organisms Identified during the ASPECT-cIAI Study
Eliana S. Armstrong, David J. Farrell, Melissa Palchak, Judith N. Steenbergen
Clinical Therapeutics
Ertapenem-Containing Double-Carbapenem Therapy for Treatment of Infections Caused by Carbapenem-Resistant Klebsiella pneumoniae
Jessica B. Cprek, Jason C. Gallagher

Pharmacology

Pharmacology
Validation and Application of a Dried Blood Spot Ceftriaxone Assay
Madhu Page-Sharp, Troy Nunn, Sam Salman, Brioni R. Moore, Kevin T. Batty, Timothy M. E. Davis, Laurens Manning
Pharmacology
Pharmacokinetics/Pharmacodynamics of Peptide Deformylase Inhibitor GSK1322322 against Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus in Rodent Models of Infection
Jennifer Hoover, Thomas Lewandowski, Robert J. Straub, Steven J. Novick, Peter DeMarsh, Kelly Aubart, Stephen Rittenhouse, Magdalena Zalacain
Pharmacology
Pharmacokinetic-Pharmacodynamic Model for the Effect of l-Arginine on Endothelial Function in Patients with Moderately Severe Falciparum Malaria
Janneke M. Brussee, Tsin W. Yeo, Daniel A. Lampah, Nicholas M. Anstey, Stephen B. Duffull
Pharmacology
Pharmacodynamics of Isavuconazole in a Dynamic In Vitro Model of Invasive Pulmonary Aspergillosis
Helen Box, Joanne Livermore, Adam Johnson, Laura McEntee, Timothy W. Felton, Sarah Whalley, Joanne Goodwin, William W. Hope
Pharmacology
Pharmacodynamics of Ceftazidime and Avibactam in Neutropenic Mice with Thigh or Lung Infection
Johanna Berkhout, Maria J. Melchers, Anita C. van Mil, Seyedmojtaba Seyedmousavi, Claudia M. Lagarde, Virna J. Schuck, Wright W. Nichols, Johan W. Mouton
Pharmacology
Network Meta-analysis and Pharmacoeconomic Evaluation of Fluconazole, Itraconazole, Posaconazole, and Voriconazole in Invasive Fungal Infection Prophylaxis
Ying Jiao Zhao, Ai Leng Khoo, Gloria Tan, Monica Teng, Caroline Tee, Ban Hock Tan, Benjamin Ong, Boon Peng Lim, Louis Yi Ann Chai
Pharmacology
Influence of Colistin Dose on Global Cure in Patients with Bacteremia Due to Carbapenem-Resistant Gram-Negative Bacilli
Gabrielle A. Gibson, Seth R. Bauer, Elizabeth A. Neuner, Stephanie N. Bass, Simon W. Lam
Pharmacology
Model-Based Evaluation of Higher Doses of Rifampin Using a Semimechanistic Model Incorporating Autoinduction and Saturation of Hepatic Extraction
Maxwell T. Chirehwa, Roxana Rustomjee, Thuli Mthiyane, Philip Onyebujoh, Peter Smith, Helen McIlleron, Paolo Denti
Pharmacology
Pharmacodynamics of Ceftolozane plus Tazobactam Studied in an In Vitro Pharmacokinetic Model of Infection
Alasdair P. MacGowan, Alan R. Noel, Sharon G. Tomaselli, Donna Nicholls, Karen E. Bowker
Pharmacology
Population Pharmacokinetics and Pharmacodynamics of Extended-Infusion Piperacillin and Tazobactam in Critically Ill Children
Kristen Nichols, Eun Kyoung Chung, Chad A. Knoderer, Lauren E. Buenger, Daniel P. Healy, Jennifer Dees, Ashley S. Crumby, Michael B. Kays
Pharmacology
Effect of SLCO1B1 Polymorphisms on Rifabutin Pharmacokinetics in African HIV-Infected Patients with Tuberculosis
Stefanie Hennig, Suhashni Naiker, Tarylee Reddy, Deirdre Egan, Tracy Kellerman, Lubbe Wiesner, Andrew Owen, Helen McIlleron, Alexander Pym
Pharmacology
Cadazolid Does Not Promote Intestinal Colonization of Vancomycin-Resistant Enterococci in Mice
Peter Seiler, Michel Enderlin-Paput, Philippe Pfaff, Maria Weiss, Daniel Ritz, Martine Clozel, Hans H. Locher

Letter to the Editor

Letter to the Editor
Effect of Meropenem Concentration on the Detection of Low Numbers of Carbapenem-Resistant Enterobacteriaceae
Windy D. Tanner, Robyn M. Atkinson, Ramesh K. Goel, Christina A. Porucznik, Lowell Scott Benson, James A. VanDerslice

Errata

Free

Errata
Erratum for Bueno et al., Coproduction of 16S rRNA Methyltransferase RmtD or RmtG with KPC-2 and CTX-M Group Extended-Spectrum β-Lactamases in Klebsiella pneumoniae
Maria Fernanda C. Bueno, Gabriela R. Francisco, Jessica A. O'Hara, Doroti de Oliveira Garcia, Yohei Doi
Free

Errata
Erratum for Antonov et al., “Erratum for Antonov et al., High Prevalence of Pupirocin Resistance in Staphylococcus aureus Isolates from a Pediatric Population”
Nina K. Antonov, Maria C. Garzon, Kimberly D. Morel, Susan Whittier, Paul J. Planet, Christine T. Lauren

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Table of Contents

Challenging Clinical Cases in Antimicrobial Resistance

Chemistry; Biosynthesis

Mechanisms of Action: Physiological Effects

Mechanisms of Resistance

Susceptibility

Analytical Procedures

Antiviral Agents

Epidemiology and Surveillance

Experimental Therapeutics

Clinical Therapeutics

Pharmacology

Letter to the Editor

Errata

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