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Clinical Therapeutics

Phase I Study Assessing the Pharmacokinetic Profile, Safety, and Tolerability of a Single Dose of Ceftazidime-Avibactam in Hospitalized Pediatric Patients

John S. Bradley, Jon Armstrong, Antonio Arrieta, Raafat Bishai, Shampa Das, Shirley Delair, Timi Edeki, William C. Holmes, Jianguo Li, Kathryn S. Moffett, Deepa Mukundan, Norma Perez, José R. Romero, David Speicher, Janice E. Sullivan, Diansong Zhou
John S. Bradley
aUniversity of California, San Diego, California, USA
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Jon Armstrong
bAstraZeneca, Macclesfield, United Kingdom
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Antonio Arrieta
cChildren's Hospital of Orange County, Orange, California, USA
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Raafat Bishai
dAstraZeneca, Gaithersburg, Maryland, USA
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Shampa Das
bAstraZeneca, Macclesfield, United Kingdom
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Shirley Delair
eChildren's Hospital & Medical Center, Omaha, Nebraska, USA
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Timi Edeki
fAstraZeneca, Wilmington, Delaware, USA
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William C. Holmes
dAstraZeneca, Gaithersburg, Maryland, USA
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Jianguo Li
gAstraZeneca, Waltham, Massachusetts, USA
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Kathryn S. Moffett
hWest Virginia University, Morgantown, West Virginia, USA
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Deepa Mukundan
iUniversity of Toledo, Toledo, Ohio, USA
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Norma Perez
jUniversity of Texas Health Science Center, Houston, Texas, USA
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José R. Romero
kUniversity of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Arkansas, USA
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David Speicher
lUniversity Hospitals Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA
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Janice E. Sullivan
mUniversity of Louisville and Kosair Children's Hospital, Louisville, Kentucky, USA
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Diansong Zhou
gAstraZeneca, Waltham, Massachusetts, USA
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DOI: 10.1128/AAC.00862-16
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Article Information

DOI 
https://doi.org/10.1128/AAC.00862-16
PubMed 
27503642

Published By 
American Society for Microbiology Journals
History 
  • Received April 22, 2016
  • Returned for modification May 24, 2016
  • Accepted July 31, 2016
  • Published online September 23, 2016.

Copyright & Usage 
Copyright © 2016 Bradley et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

Article Versions

  • Accepted Manuscript version (August 08, 2016).
  • You are viewing the most recent version of this article.

Author Information

  1. John S. Bradleya,
  2. Jon Armstrongb,
  3. Antonio Arrietac,
  4. Raafat Bishaid,
  5. Shampa Dasb,
  6. Shirley Delaire,
  7. Timi Edekif,
  8. William C. Holmesd,
  9. Jianguo Lig,
  10. Kathryn S. Moffetth,
  11. Deepa Mukundani,
  12. Norma Perezj,
  13. José R. Romerok,
  14. David Speicherl,
  15. Janice E. Sullivanm and
  16. Diansong Zhoug
  1. aUniversity of California, San Diego, California, USA
  2. bAstraZeneca, Macclesfield, United Kingdom
  3. cChildren's Hospital of Orange County, Orange, California, USA
  4. dAstraZeneca, Gaithersburg, Maryland, USA
  5. eChildren's Hospital & Medical Center, Omaha, Nebraska, USA
  6. fAstraZeneca, Wilmington, Delaware, USA
  7. gAstraZeneca, Waltham, Massachusetts, USA
  8. hWest Virginia University, Morgantown, West Virginia, USA
  9. iUniversity of Toledo, Toledo, Ohio, USA
  10. jUniversity of Texas Health Science Center, Houston, Texas, USA
  11. kUniversity of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Arkansas, USA
  12. lUniversity Hospitals Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA
  13. mUniversity of Louisville and Kosair Children's Hospital, Louisville, Kentucky, USA
  • Address correspondence to John S. Bradley, jbradley{at}rchsd.org.
  • Citation Bradley JS, Armstrong J, Arrieta A, Bishai R, Das S, Delair S, Edeki T, Holmes WC, Li J, Moffett KS, Mukundan D, Perez N, Romero JR, Speicher D, Sullivan JE, Zhou D. 2016. Phase I study assessing the pharmacokinetic profile, safety, and tolerability of a single dose of ceftazidime-avibactam in hospitalized pediatric patients. Antimicrob Agents Chemother 60:6252–6259. doi:10.1128/AAC.00862-16.

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Phase I Study Assessing the Pharmacokinetic Profile, Safety, and Tolerability of a Single Dose of Ceftazidime-Avibactam in Hospitalized Pediatric Patients
John S. Bradley, Jon Armstrong, Antonio Arrieta, Raafat Bishai, Shampa Das, Shirley Delair, Timi Edeki, William C. Holmes, Jianguo Li, Kathryn S. Moffett, Deepa Mukundan, Norma Perez, José R. Romero, David Speicher, Janice E. Sullivan, Diansong Zhou
Antimicrobial Agents and Chemotherapy Sep 2016, 60 (10) 6252-6259; DOI: 10.1128/AAC.00862-16

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Phase I Study Assessing the Pharmacokinetic Profile, Safety, and Tolerability of a Single Dose of Ceftazidime-Avibactam in Hospitalized Pediatric Patients
John S. Bradley, Jon Armstrong, Antonio Arrieta, Raafat Bishai, Shampa Das, Shirley Delair, Timi Edeki, William C. Holmes, Jianguo Li, Kathryn S. Moffett, Deepa Mukundan, Norma Perez, José R. Romero, David Speicher, Janice E. Sullivan, Diansong Zhou
Antimicrobial Agents and Chemotherapy Sep 2016, 60 (10) 6252-6259; DOI: 10.1128/AAC.00862-16
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