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Experimental Therapeutics

Antileishmanial Activity of Ezetimibe: Inhibition of Sterol Biosynthesis, In Vitro Synergy with Azoles, and Efficacy in Experimental Cutaneous Leishmaniasis

Valter Viana Andrade-Neto, Edézio Ferreira Cunha-Júnior, Marilene Marcuzzo do Canto-Cavalheiro, Geórgia Correa Atella, Talita de Almeida Fernandes, Paulo Roberto Ribeiro Costa, Eduardo Caio Torres-Santos
Valter Viana Andrade-Neto
aLaboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
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Edézio Ferreira Cunha-Júnior
aLaboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
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Marilene Marcuzzo do Canto-Cavalheiro
aLaboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
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Geórgia Correa Atella
bInstituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
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Talita de Almeida Fernandes
cLaboratório de Química Bioorgânica, Instituto de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
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Paulo Roberto Ribeiro Costa
cLaboratório de Química Bioorgânica, Instituto de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
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Eduardo Caio Torres-Santos
aLaboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
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  • ORCID record for Eduardo Caio Torres-Santos
DOI: 10.1128/AAC.01545-16
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Article Information

DOI 
https://doi.org/10.1128/AAC.01545-16
PubMed 
27600041

Published By 
American Society for Microbiology Journals
History 
  • Received July 15, 2016
  • Returned for modification August 1, 2016
  • Accepted August 28, 2016
  • Published online October 21, 2016.

Copyright & Usage 
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (September 06, 2016).
  • You are viewing the most recent version of this article.

Author Information

  1. Valter Viana Andrade-Netoa,
  2. Edézio Ferreira Cunha-Júniora,
  3. Marilene Marcuzzo do Canto-Cavalheiroa,
  4. Geórgia Correa Atellab,
  5. Talita de Almeida Fernandesc,
  6. Paulo Roberto Ribeiro Costac and
  7. Eduardo Caio Torres-Santosa
  1. aLaboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
  2. bInstituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
  3. cLaboratório de Química Bioorgânica, Instituto de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
  • Address correspondence to Eduardo Caio Torres-Santos, ects{at}ioc.fiocruz.br.
  • Citation Andrade-Neto VV, Cunha-Júnior EF, Canto-Cavalheiro MMD, Atella GC, Fernandes TDA, Costa PRR, Torres-Santos EC. 2016. Antileishmanial activity of ezetimibe: inhibition of sterol biosynthesis, in vitro synergy with azoles, and efficacy in experimental cutaneous leishmaniasis. Antimicrob Agents Chemother 60:6844–6852. doi:10.1128/AAC.01545-16.

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Antileishmanial Activity of Ezetimibe: Inhibition of Sterol Biosynthesis, In Vitro Synergy with Azoles, and Efficacy in Experimental Cutaneous Leishmaniasis
Valter Viana Andrade-Neto, Edézio Ferreira Cunha-Júnior, Marilene Marcuzzo do Canto-Cavalheiro, Geórgia Correa Atella, Talita de Almeida Fernandes, Paulo Roberto Ribeiro Costa, Eduardo Caio Torres-Santos
Antimicrobial Agents and Chemotherapy Oct 2016, 60 (11) 6844-6852; DOI: 10.1128/AAC.01545-16

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Antileishmanial Activity of Ezetimibe: Inhibition of Sterol Biosynthesis, In Vitro Synergy with Azoles, and Efficacy in Experimental Cutaneous Leishmaniasis
Valter Viana Andrade-Neto, Edézio Ferreira Cunha-Júnior, Marilene Marcuzzo do Canto-Cavalheiro, Geórgia Correa Atella, Talita de Almeida Fernandes, Paulo Roberto Ribeiro Costa, Eduardo Caio Torres-Santos
Antimicrobial Agents and Chemotherapy Oct 2016, 60 (11) 6844-6852; DOI: 10.1128/AAC.01545-16
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