Antimicrobial Agents and Chemotherapy: 60 (4)

April 1, 2016; Volume 60,Issue 4

Mechanisms of Action: Physiological Effects

Mechanisms of Action: Physiological Effects
Nitazoxanide Inhibits Pilus Biogenesis by Interfering with Folding of the Usher Protein in the Outer Membrane
Peter Chahales, Paul S. Hoffman, David G. Thanassi
Open Access

Mechanisms of Action: Physiological Effects
Untargeted Metabolomics To Ascertain Antibiotic Modes of Action
Isabel M. Vincent, David E. Ehmann, Scott D. Mills, Manos Perros, Michael P. Barrett
Mechanisms of Action: Physiological Effects
Role of the Stringent Stress Response in the Antibiotic Resistance Phenotype of Methicillin-Resistant Staphylococcus aureus
Sandra Aedo, Alexander Tomasz

Mechanisms of Resistance

Mechanisms of Resistance
Novel Piperazine Arylideneimidazolones Inhibit the AcrAB-TolC Pump in Escherichia coli and Simultaneously Act as Fluorescent Membrane Probes in a Combined Real-Time Influx and Efflux Assay
Jürgen A. Bohnert, Sabine Schuster, Winfried V. Kern, Tadeusz Karcz, Agnieszka Olejarz, Aneta Kaczor, Jadwiga Handzlik, Katarzyna Kieć-Kononowicz
Mechanisms of Resistance
Novel Genes Related to Ceftriaxone Resistance Found among Ceftriaxone-Resistant Neisseria gonorrhoeae Strains Selected In Vitro
Zijian Gong, Wei Lai, Min Liu, Zhengshuang Hua, Yayin Sun, Qingfang Xu, Yue Xia, Yue Zhao, Xiaoyuan Xie
Mechanisms of Resistance
Mutations in gyrA and gyrB among Fluoroquinolone- and Multidrug-Resistant Mycobacterium tuberculosis Isolates
Jung-Yien Chien, Wei-Yih Chiu, Shun-Tien Chien, Chia-Jung Chiang, Chong-Jen Yu, Po-Ren Hsueh
Mechanisms of Resistance
Chlorhexidine Induces VanA-Type Vancomycin Resistance Genes in Enterococci
Pooja Bhardwaj, Elizabeth Ziegler, Kelli L. Palmer
Open Access

Mechanisms of Resistance
Identification of EnvC and Its Cognate Amidases as Novel Determinants of Intrinsic Resistance to Cationic Antimicrobial Peptides
Tamiko Oguri, Won-Sik Yeo, Taeok Bae, Hyunwoo Lee
Mechanisms of Resistance
Amino Acid Substitutions Account for Most MexS Alterations in Clinical nfxC Mutants of Pseudomonas aeruginosa
Charlotte Richardot, Paulo Juarez, Katy Jeannot, Isabelle Patry, Patrick Plésiat, Catherine Llanes
Mechanisms of Resistance
Cell Wall Changes in Amphotericin B-Resistant Strains from Candida tropicalis and Relationship with the Immune Responses Elicited by the Host
Ana C. Mesa-Arango, Cristina Rueda, Elvira Román, Jessica Quintin, María C. Terrón, Daniel Luque, Mihai G. Netea, Jesus Pla, Oscar Zaragoza
Open Access

Mechanisms of Resistance
Rapid Emergence and Evolution of Staphylococcus aureus Clones Harboring fusC-Containing Staphylococcal Cassette Chromosome Elements
Sarah L. Baines, Benjamin P. Howden, Helen Heffernan, Timothy P. Stinear, Glen P. Carter, Torsten Seemann, Jason C. Kwong, Stephen R. Ritchie, Deborah A. Williamson
Mechanisms of Resistance
Kinetic Study of Laboratory Mutants of NDM-1 Metallo-β-Lactamase and the Importance of an Isoleucine at Position 35
Francesca Marcoccia, Carlo Bottoni, Alessia Sabatini, Martina Colapietro, Paola Sandra Mercuri, Moreno Galleni, Frédéric Kerff, André Matagne, Giuseppe Celenza, Gianfranco Amicosante, Mariagrazia Perilli
Mechanisms of Resistance
Landscape of Resistance-Nodulation-Cell Division (RND)-Type Efflux Pumps in Enterobacter cloacae Complex
François Guérin, Claire Lallement, Christophe Isnard, Anne Dhalluin, Vincent Cattoir, Jean-Christophe Giard
Mechanisms of Resistance
Association of Novel Nonsynonymous Single Nucleotide Polymorphisms in ampD with Cephalosporin Resistance and Phylogenetic Variations in ampC, ampR, ompF, and ompC in Enterobacter cloacae Isolates That Are Highly Resistant to Carbapenems
Baharak Babouee Flury, Matthew J. Ellington, Katie L. Hopkins, Jane F. Turton, Michel Doumith, Richard Loy, Peter Staves, Vladimira Hinic, Reno Frei, Neil Woodford
Mechanisms of Resistance
VraH Is the Third Component of the Staphylococcus aureus VraDEH System Involved in Gallidermin and Daptomycin Resistance and Pathogenicity
Peter Popella, Sophia Krauss, Patrick Ebner, Mulugeta Nega, Julia Deibert, Friedrich Götz
Mechanisms of Resistance
Molecular Characterization of Escherichia coli Strains Isolated from Retail Meat That Harbor bla_CTX-M and fosA3 Genes
Miaomiao Xie, Dachuan Lin, Kaichao Chen, Edward Wai Chi Chan, Wen Yao, Sheng Chen
Mechanisms of Resistance
Identification of Synthetic and Natural Host Defense Peptides with Leishmanicidal Activity
A. K. Marr, S. Cen, R. E. W. Hancock, W. R. McMaster
Mechanisms of Resistance
Colistin Resistance Caused by Inactivation of the MgrB Regulator Is Not Associated with Decreased Virulence of Sequence Type 258 KPC Carbapenemase-Producing Klebsiella pneumoniae
Fabio Arena, Lucia Henrici De Angelis, Antonio Cannatelli, Vincenzo Di Pilato, Marina Amorese, Marco Maria D'Andrea, Tommaso Giani, Gian Maria Rossolini
Mechanisms of Resistance
Intra- and Interspecies Effects of Outer Membrane Vesicles from Stenotrophomonas maltophilia on β-Lactam Resistance
Simon Devos, Stephan Stremersch, Koen Raemdonck, Kevin Braeckmans, Bart Devreese
Mechanisms of Resistance
Genomic Characterization of Enterobacter cloacae Isolates from China That Coproduce KPC-3 and NDM-1 Carbapenemases
Hong Du, Liang Chen, Kalyan D. Chavda, Ruchi Pandey, Haifang Zhang, Xiaofang Xie, Yi-Wei Tang, Barry N. Kreiswirth
Mechanisms of Resistance
Mycobacterium tuberculosis Mutations Associated with Reduced Susceptibility to Linezolid
Shuo Zhang, Jiazhen Chen, Peng Cui, Wanliang Shi, Xiaohong Shi, Hongxia Niu, Denise Chan, Wing Wai Yew, Wenhong Zhang, Ying Zhang
Mechanisms of Resistance
Whole-Genome Sequence of a bla_OXA-48-Harboring Raoultella ornithinolytica Clinical Isolate from Lebanon
Charbel Al-Bayssari, Abiola Olumuyiwa Olaitan, Thongpan Leangapichart, Liliane Okdah, Fouad Dabboussi, Monzer Hamze, Jean-Marc Rolain

Susceptibility

Susceptibility
Luciferase-Based, High-Throughput Assay for Screening and Profiling Transmission-Blocking Compounds against Plasmodium falciparum Gametocytes
Leonardo Lucantoni, David A. Fidock, Vicky M. Avery
Susceptibility
Effect of Media Modified To Mimic Cystic Fibrosis Sputum on the Susceptibility of Aspergillus fumigatus, and the Frequency of Resistance at One Center
David A. Stevens, Richard B. Moss, Cathy Hernandez, Karl V. Clemons, Marife Martinez
Susceptibility
Fumarate-Mediated Persistence of Escherichia coli against Antibiotics
Jun-Seob Kim, Da-Hyeong Cho, Paul Heo, Suk-Chae Jung, Myungseo Park, Eun-Joong Oh, Jaeyun Sung, Pan-Jun Kim, Suk-Chan Lee, Dae-Hee Lee, Sarah Lee, Choong Hwan Lee, Dongwoo Shin, Yong-Su Jin, Dae-Hyuk Kweon
Susceptibility
Prediction of Fluoroquinolone Resistance in Gram-Negative Bacteria Causing Bloodstream Infections
Seejil Dan, Ansal Shah, Julie Ann Justo, P. Brandon Bookstaver, Joseph Kohn, Helmut Albrecht, Majdi N. Al-Hasan
Susceptibility
Combination of Amphotericin B and Flucytosine against Neurotropic Species of Melanized Fungi Causing Primary Cerebral Phaeohyphomycosis
S. Deng, W. Pan, W. Liao, G. S. de Hoog, A. H. G. Gerrits van den Ende, R. G. Vitale, H. Rafati, M. Ilkit, A. H. Van der Lee, A. J. M. M. Rijs, P. E. Verweij, S. Seyedmousavi
Open Access

Susceptibility
Phenotypically Adapted Mycobacterium tuberculosis Populations from Sputum Are Tolerant to First-Line Drugs
Obolbek Turapov, Benjamin D. O'Connor, Asel A. Sarybaeva, Caroline Williams, Hemu Patel, Abdullaat S. Kadyrov, Akpay S. Sarybaev, Gerrit Woltmann, Michael R. Barer, Galina V. Mukamolova
Open Access

Susceptibility
Selective Conditions for a Multidrug Resistance Plasmid Depend on the Sociality of Antibiotic Resistance
Michael J. Bottery, A. Jamie Wood, Michael A. Brockhurst
Susceptibility
The Investigational Fungal Cyp51 Inhibitor VT-1129 Demonstrates Potent In Vitro Activity against Cryptococcus neoformans and Cryptococcus gattii
Shawn R. Lockhart, Annette W. Fothergill, Naureen Iqbal, Carol B. Bolden, Nina T. Grossman, Edward P. Garvey, Stephen R. Brand, William J. Hoekstra, Robert J. Schotzinger, Elizabeth Ottinger, Thomas F. Patterson, Nathan P. Wiederhold
Susceptibility
The Recombinant Bacteriophage Endolysin HY-133 Exhibits In Vitro Activity against Different African Clonal Lineages of the Staphylococcus aureus Complex, Including Staphylococcus schweitzeri
Evgeny A. Idelevich, Frieder Schaumburg, Dennis Knaack, Anna S. Scherzinger, Wolfgang Mutter, Georg Peters, Andreas Peschel, Karsten Becker

Analytical Procedures

Analytical Procedures
Incidence and Risk Factors of Ocular Infection Caused by Staphylococcus aureus Bacteremia
Jiwon Jung, Junyeop Lee, Shi Nae Yu, Yong Kyun Kim, Ju Young Lee, Heungsup Sung, Mi-Na Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Jun Hee Woo, Joo Yong Lee, Yang Soo Kim, Yong Pil Chong
Open Access

Analytical Procedures
Validation and Clinical Evaluation of a Novel Method To Measure Miltefosine in Leishmaniasis Patients Using Dried Blood Spot Sample Collection
A. E. Kip, H. Rosing, M. J. X. Hillebrand, S. Blesson, B. Mengesha, E. Diro, A. Hailu, J. H. M. Schellens, J. H. Beijnen, T. P. C. Dorlo
Analytical Procedures
Global Urine Metabolomics in Patients Treated with First-Line Tuberculosis Drugs and Identification of a Novel Metabolite of Ethambutol
Mrinal Kumar Das, Rakesh Arya, Sanjita Debnath, Rahul Debnath, Anindita Lodh, Subasa Chandra Bishwal, Anjan Das, Ranjan Kumar Nanda

Antiviral Agents

Antiviral Agents
Novel Polyanions Inhibiting Replication of Influenza Viruses
Justyna Ciejka, Aleksandra Milewska, Magdalena Wytrwal, Jacek Wojarski, Anna Golda, Marek Ochman, Maria Nowakowska, Krzysztof Szczubialka, Krzysztof Pyrc
Antiviral Agents
A Complex Network of Interactions between S282 and G283 of Hepatitis C Virus Nonstructural Protein 5B and the Template Strand Affects Susceptibility to Sofosbuvir and Ribavirin
Anupriya S. Kulkarni, Masad J. Damha, Raymond F. Schinazi, Hongmei Mo, Brian Doehle, Selena M. Sagan, Matthias Götte
Antiviral Agents
The Hemagglutinin Stem-Binding Monoclonal Antibody VIS410 Controls Influenza Virus-Induced Acute Respiratory Distress Syndrome
Tatiana Baranovich, Jeremy C. Jones, Marion Russier, Peter Vogel, Kristy J. Szretter, Susan E. Sloan, Patrick Seiler, Jose M. Trevejo, Richard J. Webby, Elena A. Govorkova
Antiviral Agents
Antiviral Activities of Different Interferon Types and Subtypes against Hepatitis E Virus Replication
Daniel Todt, Catherine François, Anggakusuma, Patrick Behrendt, Michael Engelmann, Leonard Knegendorf, Gabrielle Vieyres, Heiner Wedemeyer, Rune Hartmann, Thomas Pietschmann, Gilles Duverlie, Eike Steinmann
Antiviral Agents
Synthetic α-Hydroxytropolones Inhibit Replication of Wild-Type and Acyclovir-Resistant Herpes Simplex Viruses
Peter J. Ireland, John E. Tavis, Michael P. D'Erasmo, Danielle R. Hirsch, Ryan P. Murelli, Mark M. Cadiz, Bindi S. Patel, Ankit K. Gupta, Tiffany C. Edwards, Maria Korom, Eileen A. Moran, Lynda A. Morrison
Antiviral Agents
Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication
Suzie Thenin-Houssier, Ian Mitchelle S. de Vera, Laura Pedro-Rosa, Angela Brady, Audrey Richard, Briana Konnick, Silvana Opp, Cindy Buffone, Jakob Fuhrmann, Smitha Kota, Blase Billack, Magdalena Pietka-Ottlik, Timothy Tellinghuisen, Hyeryun Choe, Timothy Spicer, Louis Scampavia, Felipe Diaz-Griffero, Douglas J. Kojetin, Susana T. Valente
Antiviral Agents
Doravirine Suppresses Common Nonnucleoside Reverse Transcriptase Inhibitor-Associated Mutants at Clinically Relevant Concentrations
Meizhen Feng, Nancy A. Sachs, Min Xu, Jay Grobler, Wade Blair, Daria J. Hazuda, Michael D. Miller, Ming-Tain Lai
Antiviral Agents
Contribution of Gag and Protease to HIV-1 Phenotypic Drug Resistance in Pediatric Patients Failing Protease Inhibitor-Based Therapy
Jennifer Giandhari, Adriaan E. Basson, Katherine Sutherland, Chris M. Parry, Patricia A. Cane, Ashraf Coovadia, Louise Kuhn, Gillian Hunt, Lynn Morris
Antiviral Agents
5-Azacytidine Enhances the Mutagenesis of HIV-1 by Reduction to 5-Aza-2′-Deoxycytidine
Jonathan M. O. Rawson, Michele B. Daly, Jiashu Xie, Christine L. Clouser, Sean R. Landman, Cavan S. Reilly, Laurent Bonnac, Baek Kim, Steven E. Patterson, Louis M. Mansky
Antiviral Agents
Comprehensive Screening for Naturally Occurring Hepatitis C Virus Resistance to Direct-Acting Antivirals in the NS3, NS5A, and NS5B Genes in Worldwide Isolates of Viral Genotypes 1 to 6
Juan Ángel Patiño-Galindo, Karina Salvatierra, Fernando González-Candelas, F. Xavier López-Labrador
Antiviral Agents
Escape Mutations in NS4B Render Dengue Virus Insensitive to the Antiviral Activity of the Paracetamol Metabolite AM404
Koen W. R. van Cleef, Gijs J. Overheul, Michael C. Thomassen, Jenni M. Marjakangas, Ronald P. van Rij

Epidemiology and Surveillance

Epidemiology and Surveillance
Linezolid Surveillance Results for the United States (LEADER Surveillance Program 2014)
Robert K. Flamm, Rodrigo E. Mendes, Patricia A. Hogan, Jennifer M. Streit, James E. Ross, Ronald N. Jones
Epidemiology and Surveillance
Assessment of the Worldwide Antimalarial Resistance Network Standardized Procedure for In Vitro Malaria Drug Sensitivity Testing Using SYBR Green Assay for Field Samples with Various Initial Parasitemia Levels
Agnes C. Cheruiyot, Jennifer M. Auschwitz, Patricia J. Lee, Redemptah A. Yeda, Charles O. Okello, Susan E. Leed, Mayank Talwar, Tushar Murthy, Heather W. Gaona, Mark R. Hickman, Hoseah M. Akala, Edwin Kamau, Jacob D. Johnson
Epidemiology and Surveillance
Survey of Carbapenemase-Producing Enterobacteriaceae in Companion Dogs in Madrid, Spain
Ana González-Torralba, Jesús Oteo, Alejandra Asenjo, Verónica Bautista, Elisabeth Fuentes, Juan-Ignacio Alós
Epidemiology and Surveillance
First Characterization of CTX-M-15-Producing Escherichia coli Strains Belonging to Sequence Type (ST) 410, ST224, and ST1284 from Commercial Swine in South America
Ketrin C. Silva, Marina Moreno, Carlos Cabrera, Beny Spira, Louise Cerdeira, Nilton Lincopan, Andrea M. Moreno
Epidemiology and Surveillance
First Description of Two Sequence Type 2 Acinetobacter baumannii Isolates Carrying OXA-23 Carbapenemase in Pagellus acarne Fished from the Mediterranean Sea near Bejaia, Algeria
Soumia Brahmi, Abdelaziz Touati, Axelle Cadière, Nassima Djahmi, Alix Pantel, Albert Sotto, Jean-Philippe Lavigne, Catherine Dunyach-Remy
Epidemiology and Surveillance
In Vitro Activity of Ceftazidime-Avibactam against Contemporary Pseudomonas aeruginosa Isolates from U.S. Medical Centers by Census Region, 2014
Michael D. Huband, Mariana Castanheira, Robert K. Flamm, David J. Farrell, Ronald N. Jones, Helio S. Sader
Epidemiology and Surveillance
Population Structure Analysis of Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates from Brazil Reveals Predominance of Clonal Complexes 1, 15, and 79
Carlos Henrique Camargo, Monique Ribeiro Tiba, Marta Regina Saes, Francielli Mahnic de Vasconcellos, Luis Fernando dos Santos, Eliete Caló Romero, Doroti de Oliveira Garcia
Epidemiology and Surveillance
Antimicrobial Activities of Ceftaroline and Comparator Agents against Bacterial Organisms Causing Bacteremia in Patients with Skin and Skin Structure Infections in U.S. Medical Centers, 2008 to 2014
Helio S. Sader, Robert K. Flamm, Rodrigo E. Mendes, David J. Farrell, Ronald N. Jones
Epidemiology and Surveillance
Antimicrobial Resistance in Salmonella in the United States from 1948 to 1995
Daniel A. Tadesse, Aparna Singh, Shaohua Zhao, Mary Bartholomew, Niketta Womack, Sherry Ayers, Patricia I. Fields, Patrick F. McDermott

Experimental Therapeutics

Experimental Therapeutics
Combinatorial Pharmacodynamics of Ceftolozane-Tazobactam against Genotypically Defined β-Lactamase-Producing Escherichia coli: Insights into the Pharmacokinetics/Pharmacodynamics of β-Lactam–β-Lactamase Inhibitor Combinations
Rachel L. Soon, Justin R. Lenhard, Zackery P. Bulman, Patricia N. Holden, Pamela Kelchlin, Judith N. Steenbergen, Lawrence V. Friedrich, Alan Forrest, Brian T. Tsuji
Open Access

Experimental Therapeutics
Destabilization of α-Helical Structure in Solution Improves Bactericidal Activity of Antimicrobial Peptides: Opposite Effects on Bacterial and Viral Targets
David O. Ulaeto, Christopher J. Morris, Marc A. Fox, Mark Gumbleton, Konrad Beck
Experimental Therapeutics
Aminophthalocyanine-Mediated Photodynamic Inactivation of Leishmania tropica
Ahmed Al-Qahtani, Saad Alkahtani, Bala Kolli, Pankaj Tripathi, Sujoy Dutta, Abdullah A. Al-Kahtane, Xiong-Jie Jiang, Dennis K. P. Ng, Kwang Poo Chang
Experimental Therapeutics
Needle-Free Delivery of Acetalated Dextran-Encapsulated AR-12 Protects Mice from Francisella tularensis Lethal Challenge
Ky V. Hoang, Heather Curry, Michael A. Collier, Hassan Borteh, Eric M. Bachelder, Larry S. Schlesinger, John S. Gunn, Kristy M. Ainslie
Experimental Therapeutics
Virulence and Resistance to Antifungal Therapies of Scopulariopsis Species
Katihuska Paredes, Javier Capilla, Emilio Mayayo, Josep Guarro
Experimental Therapeutics
Pharmacokinetics-Pharmacodynamics of Tazobactam in Combination with Piperacillin in an In Vitro Infection Model
Anthony M. Nicasio, Brian D. VanScoy, Rodrigo E. Mendes, Mariana Castanheira, Catharine C. Bulik, Olanrewaju O. Okusanya, Sujata M. Bhavnani, Alan Forrest, Ronald N. Jones, Lawrence V. Friedrich, Judith N. Steenbergen, Paul G. Ambrose
Experimental Therapeutics
The Nonartemisinin Sesquiterpene Lactones Parthenin and Parthenolide Block Plasmodium falciparum Sexual Stage Transmission
Jared N. Balaich, Derrick K. Mathias, Baldwyn Torto, Bryan T. Jackson, Dingyin Tao, Babak Ebrahimi, Brian B. Tarimo, Xavier Cheseto, Woodbridge A. Foster, Rhoel R. Dinglasan
Experimental Therapeutics
Azithromycin Dose To Maximize Efficacy and Suppress Acquired Drug Resistance in Pulmonary Mycobacterium avium Disease
Devyani Deshpande, Jotam G. Pasipanodya, Tawanda Gumbo
Experimental Therapeutics
Garcinol Inhibits GCN5-Mediated Lysine Acetyltransferase Activity and Prevents Replication of the Parasite Toxoplasma gondii
Victoria Jeffers, Hongyu Gao, Lisa A. Checkley, Yunlong Liu, Michael T. Ferdig, William J. Sullivan
Experimental Therapeutics
Sustained Nitric Oxide-Releasing Nanoparticles Induce Cell Death in Candida albicans Yeast and Hyphal Cells, Preventing Biofilm Formation In Vitro and in a Rodent Central Venous Catheter Model
Mohammed S. Ahmadi, Hiu Ham Lee, David A. Sanchez, Adam J. Friedman, Moses T. Tar, Kelvin P. Davies, Joshua D. Nosanchuk, Luis R. Martinez
Experimental Therapeutics
A High-Affinity Native Human Antibody Disrupts Biofilm from Staphylococcus aureus Bacteria and Potentiates Antibiotic Efficacy in a Mouse Implant Infection Model
Angeles Estellés, Anne-Kathrin Woischnig, Keyi Liu, Robert Stephenson, Evelene Lomongsod, Da Nguyen, Jianzhong Zhang, Manfred Heidecker, Yifan Yang, Reyna J. Simon, Edgar Tenorio, Stote Ellsworth, Anton Leighton, Stefan Ryser, Nina Khanna Gremmelmaier, Lawrence M. Kauvar
Experimental Therapeutics
Evaluation of the Efficacy of ME1111 in the Topical Treatment of Dermatophytosis in a Guinea Pig Model
L. Long, C. Hager, M. Ghannoum
Experimental Therapeutics
Oritavancin Combinations with β-Lactams against Multidrug-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci
Jordan R. Smith, Juwon Yim, Animesh Raut, Michael J. Rybak
Experimental Therapeutics
In Vitro and In Vivo Trypanosomicidal Action of Novel Arylimidamides against Trypanosoma cruzi
F. H. Guedes-da-Silva, D. G. J. Batista, M. B. Meuser, K. C. Demarque, T. O. Fulco, J. S. Araújo, P. B. Da Silva, C. F. Da Silva, D. A. Patrick, S. M. Bakunova, S. A. Bakunov, R. R. Tidwell, G. M. Oliveira, C. Britto, O. C. Moreira, M. N. C. Soeiro
Experimental Therapeutics
Dissecting the Structure-Function Relationship of a Fungicidal Peptide Derived from the Constant Region of Human Immunoglobulins
Tecla Ciociola, Thelma A. Pertinhez, Laura Giovati, Martina Sperindè, Walter Magliani, Elena Ferrari, Rita Gatti, Tiziana D'Adda, Alberto Spisni, Stefania Conti, Luciano Polonelli
Experimental Therapeutics
Low Concentrations of Nitric Oxide Modulate Streptococcus pneumoniae Biofilm Metabolism and Antibiotic Tolerance
Raymond N. Allan, Samantha Morgan, Sanjita Brito-Mutunayagam, Paul Skipp, Martin Feelisch, Stephen M. Hayes, William Hellier, Stuart C. Clarke, Paul Stoodley, Andrea Burgess, Hasnaa Ismail-Koch, Rami J. Salib, Jeremy S. Webb, Saul N. Faust, Luanne Hall-Stoodley
Experimental Therapeutics
Preventing Implant-Associated Infections by Silver Coating
Richard Kuehl, Priscilla S. Brunetto, Anne-Kathrin Woischnig, Massimo Varisco, Zarko Rajacic, Juerg Vosbeck, Luigi Terracciano, Katharina M. Fromm, Nina Khanna
Experimental Therapeutics
Benznidazole Extended-Release Tablets for Improved Treatment of Chagas Disease: Preclinical Pharmacokinetic Study
Marcelo Gomes Davanço, Michel Leandro Campos, Talita Atanazio Rosa, Elias Carvalho Padilha, Alejandro Henao Alzate, Larissa Araújo Rolim, Pedro José Rolim-Neto, Rosângela Gonçalves Peccinini
Experimental Therapeutics
Activity of Bisnaphthalimidopropyl Derivatives against Trypanosoma brucei
Nuno A. G. Graça, Luis Gaspar, David M. Costa, Inês Loureiro, Paul Kong Thoo-Lin, Isbaal Ramos, Meritxell Roura, Alain Pruvost, Ian K. Pemberton, Hadjer Loukil, Jane MacDougall, Joana Tavares, Anabela Cordeiro-da-Silva
Experimental Therapeutics
Tigecycline Potentiates Clarithromycin Activity against Mycobacterium avium In Vitro
Hannelore I. Bax, Irma A. J. M. Bakker-Woudenberg, Marian T. ten Kate, Annelies Verbon, Jurriaan E. M. de Steenwinkel

Clinical Therapeutics

Clinical Therapeutics
Multicenter Prospective Cohort Study of Renal Failure in Patients Treated with Colistin versus Polymyxin B
Maria Helena Rigatto, Maura S. Oliveira, Lauro V. Perdigão-Neto, Anna S. Levin, Claudia M. Carrilho, Marcos Toshiyuki Tanita, Felipe F. Tuon, Douglas E. Cardoso, Natane T. Lopes, Diego R. Falci, Alexandre P. Zavascki
Clinical Therapeutics
Is Aerosolized Pentamidine for Pneumocystis Pneumonia Prophylaxis in Renal Transplant Recipients Not as Safe as We Might Think?
N. Macesic, K. Urbancic, F. Ierino, M. L. Grayson

Pharmacology

Pharmacology
Contribution of Population Pharmacokinetics to Dose Optimization of Ganciclovir-Valganciclovir in Solid-Organ Transplant Patients
A. Padullés, H. Colom, O. Bestard, E. Melilli, N. Sabé, R. Rigo, J. Niubó, J. Torras, L. Lladó, N. Manito, A. Caldés, J. M. Cruzado, J. M. Grinyó, N. Lloberas
Pharmacology
Clinical Utility and Safety of a Model-Based Patient-Tailored Dose of Vancomycin in Neonates
Stéphanie Leroux, Evelyne Jacqz-Aigrain, Valérie Biran, Emmanuel Lopez, Doriane Madeleneau, Camille Wallon, Elodie Zana-Taïeb, Anne-Laure Virlouvet, Stéphane Rioualen, Wei Zhao
and on behalf of the VANCO IVC Study Group
Pharmacology
Impact of Surotomycin on the Gut Microbiota of Healthy Volunteers in a Phase 1 Clinical Trial
Diane M. Citron, Kerin L. Tyrrell, Suzanne E. Dale, Laurent Chesnel, Ellie J. C. Goldstein
Pharmacology
Population Pharmacokinetic Assessment and Pharmacodynamic Implications of Pediatric Cefepime Dosing for Susceptible-Dose-Dependent Organisms
Kensuke Shoji, John S. Bradley, Michael D. Reed, John N. van den Anker, Christine Domonoske, Edmund V. Capparelli
Pharmacology
Pharmacokinetics of Rifampin, Isoniazid, Pyrazinamide, and Ethambutol in Infants Dosed According to Revised WHO-Recommended Treatment Guidelines
A. Bekker, H. S. Schaaf, H. R. Draper, L. van der Laan, S. Murray, L. Wiesner, P. R. Donald, H. M. McIlleron, A. C. Hesseling
Pharmacology
Pharmacodynamics of Voriconazole in Children: Further Steps along the Path to True Individualized Therapy
Luc J. Huurneman, Michael Neely, Anette Veringa, Fernando Docobo Pérez, Virginia Ramos-Martin, Wim J. Tissing, Jan-Willem C. Alffenaar, William Hope
Pharmacology
Removal of Dolutegravir by Hemodialysis in HIV-Infected Patients with End-Stage Renal Disease
José Moltó, Fredzzia Graterol, Cristina Miranda, Saye Khoo, Ioana Bancu, Alieu Amara, Anna Bonjoch, Bonaventura Clotet
Pharmacology
Solithromycin Pharmacokinetics in Plasma and Dried Blood Spots and Safety in Adolescents
Daniel Gonzalez, Debra L. Palazzi, Leena Bhattacharya-Mithal, Amira Al-Uzri, Laura P. James, John Bradley, Natalie Neu, Theresa Jasion, Christoph P. Hornik, P. Brian Smith, Daniel K. Benjamin, Kara Keedy, Prabhavathi Fernandes, Michael Cohen-Wolkowiez

Letters to the Editor

LETTERS TO THE EDITOR
A Highly Macrolide-Resistant Campylobacter jejuni Strain with Rare A2074T Mutations in 23S rRNA Genes
Hiroe Ohno, Jun-ichi Wachino, Ryoichi Saito, Wanchun Jin, Keiko Yamada, Kouji Kimura, Yoshichika Arakawa
LETTERS TO THE EDITOR
High Prevalence of Chromosomal bla_CTX-M-14 in Escherichia coli Isolates Possessing bla_CTX-M-14
Kouta Hamamoto, Shuhei Ueda, Takehiko Toyosato, Yoshimasa Yamamoto, Itaru Hirai
LETTERS TO THE EDITOR
VIM-1, VIM-34, and IMP-8 Carbapenemase-Producing Escherichia coli Strains Recovered from a Portuguese River
Nicolas Kieffer, Laurent Poirel, Lucinda J. Bessa, Ana Barbosa-Vasconcelos, Paulo Martins da Costa, Patrice Nordmann
LETTERS TO THE EDITOR
A Multicenter Study in Mexico Finds Acinetobacter baumannii Clinical Isolates Belonging to Clonal Complexes 636^B (113^B) and 92^B Harboring OXA-72, OXA-239, and OXA-469
Ana M. Gonzalez-Villoria, Elsa Tamayo-Legorreta, Ulises Garza-Ramos, Humberto Barrios, Alejandro Sanchez-Pérez, Nadia Rodríguez-Medina, Naville Uribe-Aviña, Miguel A. Cevallos, CRAB Study Group,, Jesus Silva-Sanchez
LETTERS TO THE EDITOR
Old Clinical Isolates of Acinetobacter seifertii in Brazil Producing OXA-58
Rodrigo Cayô, Fernanda Rodrigues-Costa, Adriana Pereira Matos, Cecilia Godoy Carvalhaes, Lenie Dijkshoorn, Ana Cristina Gales
LETTERS TO THE EDITOR
Delayed Onset of Plasmodium falciparum Malaria after Doxycycline Prophylaxis in a Soldier Returning from the Central African Republic
Emilie Javelle, Marylin Madamet, Tiphaine Gaillard, Guillaume Velut, Corinne Surcouf, Rémy Michel, Eric Garnotel, Fabrice Simon, Bruno Pradines
LETTERS TO THE EDITOR
Occurrence of the Plasmid-Borne mcr-1 Colistin Resistance Gene in Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae in River Water and Imported Vegetable Samples in Switzerland
Katrin Zurfuh, Laurent Poirel, Patrice Nordmann, Magdalena Nüesch-Inderbinen, Herbert Hächler, Roger Stephan
LETTERS TO THE EDITOR
Urinary Tract Infections: Resistance Is Futile
Eric Wenzler, Larry H. Danziger
LETTERS TO THE EDITOR
Reply to “Urinary Tract Infections: Resistance Is Futile”
Rachel M. Kenney, Kelli A. Cole, Mary Beth Perri, Lisa E. Dumkow, Linoj P. Samuel, Marcus J. Zervos, Susan L. Davis

Errata

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Errata
Erratum for Gudeta et al., The Soil Microbiota Harbors a Diversity of Carbapenem-Hydrolyzing β-Lactamases of Potential Clinical Relevance
Dereje Dadi Gudeta, Valeria Bortolaia, Greg Amos, Elizabeth M. H. Wellington, Kristian K. Brandt, Laurent Poirel, Jesper Boye Nielsen, Henrik Westh, Luca Guardabassi
Free

Errata
Erratum for Song et al., Exploring Synergy between Classic Mutagens and Antibiotics To Examine Mechanisms of Synergy and Antibiotic Action
Lisa Yun Song, Sara D'Souza, Karen Lam, Tina Manzhu Kang, Pamela Yeh, Jeffrey H. Miller

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Table of Contents

Mechanisms of Action: Physiological Effects

Mechanisms of Resistance

Susceptibility

Analytical Procedures

Antiviral Agents

Epidemiology and Surveillance

Experimental Therapeutics

Clinical Therapeutics

Pharmacology

Letters to the Editor

Errata

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