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Table of Contents

June 1, 2016; Volume 60,Issue 6

Commentary

  • Commentary
    Investigating the Extremes of Antibiotic Use with an Epidemiologic Framework
    Marc H. Scheetz, Page E. Crew, Cristina Miglis, Elise M. Gilbert, Sarah H. Sutton, J. Nick O'Donnell, Michael Postelnick, Teresa Zembower, Nathaniel J. Rhodes

Challenging Clinical Case in Antimicrobial Resistance

  • Free
    Challenging Clinical Cases in Antimicrobial Resistance
    An Immunocompromised Child with Bloodstream Infection Caused by Two Escherichia coli Strains, One Harboring NDM-5 and the Other Harboring OXA-48-Like Carbapenemase
    M. Earth Hasassri, Thomas G. Boyce, Andrew Norgan, Scott A. Cunningham, Patricio R. Jeraldo, Scott Weissman, Robin Patel, Ritu Banerjee, Jason M. Pogue, Keith S. Kaye

Chemistry; Biosynthesis

  • Chemistry; Biosynthesis
    Novel Heteroaryl Selenocyanates and Diselenides as Potent Antileishmanial Agents
    Ylenia Baquedano, Verónica Alcolea, Miguel Ángel Toro, Killian Jesús Gutiérrez, Paul Nguewa, María Font, Esther Moreno, Socorro Espuelas, Antonio Jiménez-Ruiz, Juan Antonio Palop, Daniel Plano, Carmen Sanmartín
  • Chemistry; Biosynthesis
    Elucidation of Mechanisms of Ceftazidime Resistance among Clinical Isolates of Pseudomonas aeruginosa by Using Genomic Data
    Veronica N. Kos, Robert E. McLaughlin, Humphrey A. Gardner

Mechanisms of Action: Physiological Effects

  • Mechanisms of Action: Physiological Effects
    Effects of Saline, an Ambient Acidic Environment, and Sodium Salicylate on OXA-Mediated Carbapenem Resistance in Acinetobacter baumannii
    Esther Zander, Harald Seifert, Paul G. Higgins
  • Mechanisms of Action: Physiological Effects
    In Vitro and In Vivo Activities of 2,3-Diarylsubstituted Quinoxaline Derivatives against Leishmania amazonensis
    Vanessa Kaplum, Juliana Cogo, Diego Pereira Sangi, Tânia Ueda-Nakamura, Arlene Gonçalves Corrêa, Celso Vataru Nakamura
  • Mechanisms of Action: Physiological Effects
    Secreted Compounds of the Probiotic Bacillus clausii Strain O/C Inhibit the Cytotoxic Effects Induced by Clostridium difficile and Bacillus cereus Toxins
    Gabrielle Ripert, Silvia M. Racedo, Anne-Marie Elie, Claudine Jacquot, Philippe Bressollier, Maria C. Urdaci
  • Mechanisms of Action: Physiological Effects
    Clofazimine Biocrystal Accumulation in Macrophages Upregulates Interleukin 1 Receptor Antagonist Production To Induce a Systemic Anti-Inflammatory State
    Gi S. Yoon, Rahul K. Keswani, Sudha Sud, Phillip M. Rzeczycki, Mikhail D. Murashov, Tony A. Koehn, Theodore J. Standiford, Kathleen A. Stringer, Gus R. Rosania
  • Mechanisms of Action: Physiological Effects
    High Intracellular Concentrations of Posaconazole Do Not Impact on Functional Capacities of Human Polymorphonuclear Neutrophils and Monocyte-Derived Macrophages In Vitro
    Fedja Farowski, Oliver A. Cornely, Pia Hartmann
  • Open Access
    Mechanisms of Action: Physiological Effects
    Berberine Antifungal Activity in Fluconazole-Resistant Pathogenic Yeasts: Action Mechanism Evaluated by Flow Cytometry and Biofilm Growth Inhibition in Candida spp.
    Anderson Ramos da Silva, João Batista de Andrade Neto, Cecília Rocha da Silva, Rosana de Sousa Campos, Rose Anny Costa Silva, Daniel Domingues Freitas, Francisca Bruna Stefany Aires do Nascimento, Larissa Nara Dantas de Andrade, Letícia Serpa Sampaio, Thalles Barbosa Grangeiro, Hemerson Iury Ferreira Magalhães, Bruno Coêlho Cavalcanti, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior
  • Mechanisms of Action: Physiological Effects
    Highly Dynamic and Specific Phosphatidylinositol 4,5-Bisphosphate, Septin, and Cell Wall Integrity Pathway Responses Correlate with Caspofungin Activity against Candida albicans
    Hassan Badrane, M. Hong Nguyen, Cornelius J. Clancy
  • Open Access
    Mechanisms of Action: Physiological Effects
    Enzymes Enhance Biofilm Removal Efficiency of Cleaners
    Philipp Stiefel, Stefan Mauerhofer, Jana Schneider, Katharina Maniura-Weber, Urs Rosenberg, Qun Ren

Mechanisms of Resistance

  • Mechanisms of Resistance
    Emergence and Diversity of Salmonella enterica Serovar Indiana Isolates with Concurrent Resistance to Ciprofloxacin and Cefotaxime from Patients and Food-Producing Animals in China
    Li Bai, Jiayong Zhao, Xin Gan, Juan Wang, Xiuli Zhang, Shenghui Cui, Shengli Xia, Yujie Hu, Shaofei Yan, Jiahui Wang, Fengqin Li, Séamus Fanning, Jin Xu
  • Mechanisms of Resistance
    SpoVG Regulates Cell Wall Metabolism and Oxacillin Resistance in Methicillin-Resistant Staphylococcus aureus Strain N315
    Xiaoyu Liu, Shijie Zhang, Baolin Sun
  • Mechanisms of Resistance
    Analysis of β-Lactamase Resistance Determinants in Enterobacteriaceae from Chicago Children: a Multicenter Survey
    Latania K. Logan, Andrea M. Hujer, Steven H. Marshall, T. Nicholas Domitrovic, Susan D. Rudin, Xiaotian Zheng, Nadia K. Qureshi, Mary K. Hayden, Felicia A. Scaggs, Anand Karadkhele, Robert A. Bonomo
  • Mechanisms of Resistance
    The LABCG2 Transporter from the Protozoan Parasite Leishmania Is Involved in Antimony Resistance
    Ana Perea, José Ignacio Manzano, Santiago Castanys, Francisco Gamarro
  • Mechanisms of Resistance
    Resistance Mechanisms and Clinical Features of Fluconazole-Nonsusceptible Candida tropicalis Isolates Compared with Fluconazole-Less-Susceptible Isolates
    Min Ji Choi, Eun Jeong Won, Jong Hee Shin, Soo Hyun Kim, Wee-Gyo Lee, Mi-Na Kim, Kyungwon Lee, Myung Geun Shin, Soon Pal Suh, Dong Wook Ryang, Young Jun Im
  • Mechanisms of Resistance
    Amino Acid Substitutions of CrrB Responsible for Resistance to Colistin through CrrC in Klebsiella pneumoniae
    Yi-Hsiang Cheng, Tzu-Lung Lin, Yi-Tsung Lin, Jin-Town Wang
  • Open Access
    Mechanisms of Resistance
    Complete Reconstitution of the Vancomycin-Intermediate Staphylococcus aureus Phenotype of Strain Mu50 in Vancomycin-Susceptible S. aureus
    Yuki Katayama, Miwa Sekine, Tomomi Hishinuma, Yoshifumi Aiba, Keiichi Hiramatsu
  • Mechanisms of Resistance
    Mutations Decreasing Intrinsic β-Lactam Resistance Are Linked to Cell Division in the Nosocomial Pathogen Acinetobacter baumannii
    Daniel Knight, Daniela D. Dimitrova, Susan D. Rudin, Robert A. Bonomo, Philip N. Rather
  • Mechanisms of Resistance
    Advanced Molecular Detection of Malarone Resistance
    Eldin Talundzic, Mateusz M. Plucinski, Shweta Biliya, Luciana M. Silva-Flannery, Paul M. Arguin, Eric S. Halsey, John W. Barnwell, Fredrik Vannberg, Venkatachalam Udhayakumar
  • Mechanisms of Resistance
    Rapid Flow Cytometry Test for Identification of Different Carbapenemases in Enterobacteriaceae
    Ana P. Silva, Isabel Faria-Ramos, Elisabete Ricardo, Isabel M. Miranda, Maria J. Espinar, Sofia Costa-de-Oliveira, Rafael Cantón, Acácio G. Rodrigues, Cidália Pina-Vaz
  • Mechanisms of Resistance
    Molecular Epidemiology and Genetic Characteristics of Various blaPER Genes in Shanghai, China
    Lianyan Xie, Jun Wu, Fangfang Zhang, Lizhong Han, Xiaokui Guo, Yuxing Ni, Jingyong Sun

Susceptibility

  • Susceptibility
    MIC of Delamanid (OPC-67683) against Mycobacterium tuberculosis Clinical Isolates and a Proposed Critical Concentration
    Kelly Stinson, Natalia Kurepina, Amour Venter, Mamoru Fujiwara, Masanori Kawasaki, Juliano Timm, Elena Shashkina, Barry N. Kreiswirth, Yongge Liu, Makoto Matsumoto, Lawrence Geiter
  • Susceptibility
    A Replicative In Vitro Assay for Drug Discovery against Leishmania donovani
    Diana Tegazzini, Rosario Díaz, Fernando Aguilar, Imanol Peña, Jesús L. Presa, Vanessa Yardley, Julio J. Martin, Jose M. Coteron, Simon L. Croft, Juan Cantizani
  • Susceptibility
    Biofilm Production and Antibiofilm Activity of Echinocandins and Liposomal Amphotericin B in Echinocandin-Resistant Yeast Species
    Laura Judith Marcos-Zambrano, Marta Gómez-Perosanz, Pilar Escribano, Oscar Zaragoza, Emilio Bouza, Jesús Guinea
  • Susceptibility
    In Vitro Interactions between Target of Rapamycin Kinase Inhibitor and Antifungal Agents against Aspergillus Species
    Lujuan Gao, Xiaozhen Ding, Zhun Liu, Qingzhi Wu, Tongxiang Zeng, Yi Sun
  • Susceptibility
    In Vitro Activity of Eravacycline against Carbapenem-Resistant Enterobacteriaceae and Acinetobacter baumannii
    David M. Livermore, Shazad Mushtaq, Marina Warner, Neil Woodford
  • Susceptibility
    Impact of Cefepime Susceptible-Dose-Dependent MIC for Enterobacteriaceae on Reporting and Prescribing
    Christina G. Rivera, Prasanna P. Narayanan, Robin Patel, Lynn L. Estes

Antiviral Agents

  • Antiviral Agents
    Low-Frequency Drug Resistance in HIV-Infected Ugandans on Antiretroviral Treatment Is Associated with Regimen Failure
    Fred Kyeyune, Richard M. Gibson, Immaculate Nankya, Colin Venner, Samar Metha, Juliet Akao, Emmanuel Ndashimye, Cissy M. Kityo, Robert A. Salata, Peter Mugyenyi, Eric J. Arts, Miguel E. Quiñones-Mateu
  • Antiviral Agents
    Hepatitis C Virus RNA-Dependent RNA Polymerase Interacts with the Akt/PKB Kinase and Induces Its Subcellular Relocalization
    María Llanos Valero, Rosario Sabariegos, Francisco J. Cimas, Celia Perales, Esteban Domingo, Ricardo Sánchez-Prieto, Antonio Mas
  • Antiviral Agents
    Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle
    Stéphanie B. N. Serre, Sanne B. Jensen, Lubna Ghanem, Daryl G. Humes, Santseharay Ramirez, Yi-Ping Li, Henrik Krarup, Jens Bukh, Judith M. Gottwein
  • Open Access
    Antiviral Agents
    Population Pharmacokinetics Analysis To Inform Efavirenz Dosing Recommendations in Pediatric HIV Patients Aged 3 Months to 3 Years
    Man Luo, Sunny Chapel, Heather Sevinsky, Ishani Savant, Brenda Cirincione, Richard Bertz, Amit Roy
  • Antiviral Agents
    Barrier-Independent, Fitness-Associated Differences in Sofosbuvir Efficacy against Hepatitis C Virus
    Isabel Gallego, Julie Sheldon, Elena Moreno, Josep Gregori, Josep Quer, Juan Ignacio Esteban, Charles M. Rice, Esteban Domingo, Celia Perales
  • Antiviral Agents
    Novel Cytomegalovirus UL54 DNA Polymerase Gene Mutations Selected In Vitro That Confer Brincidofovir Resistance
    Sunwen Chou, Ronald J. Ercolani, E. Randall Lanier

Epidemiology and Surveillance

  • Epidemiology and Surveillance
    Little Polymorphism at the K13 Propeller Locus in Worldwide Plasmodium falciparum Populations Prior to the Introduction of Artemisinin Combination Therapies
    Toshihiro Mita, Richard Culleton, Nobuyuki Takahashi, Masatoshi Nakamura, Takahiro Tsukahara, Carol W. Hunja, Zin Zayar Win, Wah Win Htike, Aung S. Marma, Lek Dysoley, Mathieu Ndounga, Mawuli Dzodzomenyo, Willis S. Akhwale, Jun Kobayashi, Haruki Uemura, Akira Kaneko, Francis Hombhanje, Marcelo U. Ferreira, Anders Björkman, Hiroyoshi Endo, Jun Ohashi
  • Epidemiology and Surveillance
    Dalbavancin Activity When Tested against Streptococcus pneumoniae Isolated in Medical Centers on Six Continents (2011 to 2014)
    Ronald N. Jones, Jason E. Schuchert, Rodrigo E. Mendes
  • Epidemiology and Surveillance
    Results from the Solithromycin International Surveillance Program (2014)
    David J. Farrell, Robert K. Flamm, Helio S. Sader, Ronald N. Jones
  • Open Access
    Epidemiology and Surveillance
    Nested Russian Doll-Like Genetic Mobility Drives Rapid Dissemination of the Carbapenem Resistance Gene blaKPC
    Anna E. Sheppard, Nicole Stoesser, Daniel J. Wilson, Robert Sebra, Andrew Kasarskis, Luke W. Anson, Adam Giess, Louise J. Pankhurst, Alison Vaughan, Christopher J. Grim, Heather L. Cox, Anthony J. Yeh, the Modernising Medical Microbiology (MMM) Informatics Group, Costi D. Sifri, A. Sarah Walker, Tim E. Peto, Derrick W. Crook, Amy J. Mathers
  • Epidemiology and Surveillance
    Oritavancin Activity Tested against Molecularly Characterized Staphylococci and Enterococci Displaying Elevated Linezolid MIC Results
    Rodrigo E. Mendes, David J. Farrell, Helio S. Sader, Robert K. Flamm, Ronald N. Jones
  • Epidemiology and Surveillance
    Activity of Fusidic Acid Tested against Staphylococci Isolated from Patients in U.S. Medical Centers in 2014
    David J. Farrell, Rodrigo E. Mendes, Mariana Castanheira, Ronald N. Jones
  • Epidemiology and Surveillance
    Improvement of the Xpert Carba-R Kit for the Detection of Carbapenemase-Producing Enterobacteriaceae
    Laurent Dortet, Mathieu Fusaro, Thierry Naas

Experimental Therapeutics

  • Experimental Therapeutics
    Inhibitors of Ribosome Rescue Arrest Growth of Francisella tularensis at All Stages of Intracellular Replication
    Tyler D. P. Goralski, Kalyan K. Dewan, John N. Alumasa, Victoria Avanzato, David E. Place, Rachel L. Markley, Bhuvana Katkere, Seham M. Rabadi, Chandra Shekhar Bakshi, Kenneth C. Keiler, Girish S. Kirimanjeswara
  • Experimental Therapeutics
    In Vitro Screening of the Open-Source Medicines for Malaria Venture Malaria Box Reveals Novel Compounds with Profound Activities against Theileria annulata Schizonts
    Isabel Hostettler, Joachim Müller, Andrew Hemphill
  • Experimental Therapeutics
    Effect of Surotomycin, a Novel Cyclic Lipopeptide Antibiotic, on Intestinal Colonization with Vancomycin-Resistant Enterococci and Klebsiella pneumoniae in Mice
    Abhishek Deshpande, Kelly Hurless, Jennifer L. Cadnum, Laurent Chesnel, Lihong Gao, Luisa Chan, Sirisha Kundrapu, Alexander Polinkovsky, Curtis J. Donskey
  • Experimental Therapeutics
    Candida albicans Airway Colonization Facilitates Subsequent Acinetobacter baumannii Pneumonia in a Rat Model
    Xiaojiang Tan, Ruilan Chen, Song Zhu, Huijun Wang, Dongxing Yan, Xiangdong Zhang, Dimitrios Farmakiotis, Eleftherios Mylonakis
  • Experimental Therapeutics
    Curcumin Enhances the Anti-Trypanosoma cruzi Activity of Benznidazole-Based Chemotherapy in Acute Experimental Chagas Disease
    Rômulo Dias Novaes, Marcus Vinicius Pessoa Sartini, João Paulo Ferreira Rodrigues, Reggiani Vilela Gonçalves, Eliziária Cardoso Santos, Raquel Lopes Martins Souza, Ivo Santana Caldas
  • Experimental Therapeutics
    Efficacy of Artilysin Art-175 against Resistant and Persistent Acinetobacter baumannii
    Valerie Defraine, Joris Schuermans, Barbara Grymonprez, Sander K. Govers, Abram Aertsen, Maarten Fauvart, Jan Michiels, Rob Lavigne, Yves Briers
  • Experimental Therapeutics
    Potentiation of Aminoglycoside Activity in Pseudomonas aeruginosa by Targeting the AmgRS Envelope Stress-Responsive Two-Component System
    Keith Poole, Christie Gilmour, Maya A. Farha, Erin Mullen, Calvin Ho-Fung Lau, Eric D. Brown
  • Experimental Therapeutics
    Oxadiazoles Have Butyrate-Specific Conditional Activity against Mycobacterium tuberculosis
    Julie V. Early, Allen Casey, Maria Angeles Martinez-Grau, Isabel C. Gonzalez Valcarcel, Michal Vieth, Juliane Ollinger, Mai Ann Bailey, Torey Alling, Megan Files, Yulia Ovechkina, Tanya Parish
  • Experimental Therapeutics
    In Vivo Pharmacodynamic Target Investigation of Two Bacterial Topoisomerase Inhibitors, ACT-387042 and ACT-292706, in the Neutropenic Murine Thigh Model against Streptococcus pneumoniae and Staphylococcus aureus
    A. J. Lepak, P. Seiler, J. P. Surivet, D. Ritz, C. Kohl, D. R. Andes
  • Experimental Therapeutics
    Topical Tenofovir Disoproxil Fumarate Nanoparticles Prevent HIV-1 Vaginal Transmission in a Humanized Mouse Model
    Christopher J. Destache, Subhra Mandal, Zhe Yuan, Guobin Kang, Abhijit A. Date, Wuxun Lu, Annemarie Shibata, Rachel Pham, Patrick Bruck, Michael Rezich, You Zhou, Renuga Vivekanandan, Courtney V. Fletcher, Qingsheng Li
  • Open Access
    Experimental Therapeutics
    Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development
    James S. McCarthy, Louise Marquart, Silvana Sekuloski, Katharine Trenholme, Suzanne Elliott, Paul Griffin, Rebecca Rockett, Peter O'Rourke, Theo Sloots, Iñigo Angulo-Barturen, Santiago Ferrer, María Belén Jiménez-Díaz, María-Santos Martínez, Rob Hooft van Huijsduijnen, Stephan Duparc, Didier Leroy, Timothy N. C. Wells, Mark Baker, Jörg J. Möhrle
  • Experimental Therapeutics
    Single Amino Acid Substitutions at Specific Positions of the Heptad Repeat Sequence of Piscidin-1 Yielded Novel Analogs That Show Low Cytotoxicity and In Vitro and In Vivo Antiendotoxin Activity
    Amit Kumar, Amit Kumar Tripathi, Manoj Kathuria, Sonal Shree, Jitendra Kumar Tripathi, R. K. Purshottam, Ravishankar Ramachandran, Kalyan Mitra, Jimut Kanti Ghosh
  • Experimental Therapeutics
    New Role for FDA-Approved Drugs in Combating Antibiotic-Resistant Bacteria
    Jourdan A. Andersson, Eric C. Fitts, Michelle L. Kirtley, Duraisamy Ponnusamy, Alex G. Peniche, Sara M. Dann, Vladimir L. Motin, Sadhana Chauhan, Jason A. Rosenzweig, Jian Sha, Ashok K. Chopra
  • Experimental Therapeutics
    Moxifloxacin's Limited Efficacy in the Hollow-Fiber Model of Mycobacterium abscessus Disease
    Beatriz E. Ferro, Shashikant Srivastava, Devyani Deshpande, Jotam G. Pasipanodya, Dick van Soolingen, Johan W. Mouton, Jakko van Ingen, Tawanda Gumbo
  • Experimental Therapeutics
    Preclinical Studies Evaluating Subacute Toxicity and Therapeutic Efficacy of LQB-118 in Experimental Visceral Leishmaniasis
    Edézio Ferreira Cunha-Júnior, Thiago Martino Martins, Marilene Marcuzzo Canto-Cavalheiro, Paulo Roberto Marques, Elyzabeth Avvad Portari, Marsen Garcia Pinto Coelho, Chaquip Daher Netto, Paulo Roberto Ribeiro Costa, Katia Costa de Carvalho Sabino, Eduardo Caio Torres-Santos

Clinical Therapeutics

  • Clinical Therapeutics
    Propensity Score Analysis of the Role of Initial Antifungal Therapy in the Outcome of Candida glabrata Bloodstream Infections
    M. Puig-Asensio, M. Fernández-Ruiz, J. M. Aguado, P. Merino, D. Lora-Pablos, J. Guinea, P. Martín-Dávila, M. Cuenca-Estrella, B. Almirante
    and on behalf of the CANDIPOP Project, GEIH-GEMICOMED (SEIMC), and REIPI
  • Clinical Therapeutics
    Drug-Drug Interaction Associated with Mold-Active Triazoles among Hospitalized Patients
    David Andes, Nkechi Azie, Hongbo Yang, Rachel Harrington, Caroline Kelley, Ruo-Ding Tan, Eric Q. Wu, Billy Franks, Rita Kristy, Edward Lee, Nikhil Khandelwal, James Spalding
  • Clinical Therapeutics
    Successful Salvage of Central Venous Catheters in Patients with Catheter-Related or Central Line-Associated Bloodstream Infections by Using a Catheter Lock Solution Consisting of Minocycline, EDTA, and 25% Ethanol
    Issam Raad, Anne-Marie Chaftari, Ramia Zakhour, Mary Jordan, Zanaib Al Hamal, Ying Jiang, Ammar Yousif, Kumait Garoge, Victor Mulanovich, George M. Viola, Soha Kanj, Egbert Pravinkumar, Joel Rosenblatt, Ray Hachem
  • Clinical Therapeutics
    Antitubercular Agent Delamanid and Metabolites as Substrates and Inhibitors of ABC and Solute Carrier Transporters
    Hiroyuki Sasabe, Yoshihiko Shimokawa, Masakazu Shibata, Kenta Hashizume, Yusuke Hamasako, Yoshihiro Ohzone, Eiji Kashiyama, Ken Umehara
  • Clinical Therapeutics
    Pharmacokinetics of Posaconazole Suspension in Lung Transplant Patients with and without Cystic Fibrosis
    Hongfei Zhang, M. Hong Nguyen, Cornelius J. Clancy, Rujuta Joshi, Wenchen Zhao, Chris Ensor, Raman Venkataramanan, Ryan K. Shields
  • Clinical Therapeutics
    Combination Regimens for Treatment of Carbapenem-Resistant Klebsiella pneumoniae Bloodstream Infections
    A. Gomez-Simmonds, B. Nelson, D. P. Eiras, A. Loo, S. G. Jenkins, S. Whittier, D. P. Calfee, M. J. Satlin, C. J. Kubin, E. Y. Furuya
  • Clinical Therapeutics
    Epidemiology of Acute Kidney Injury among Patients Receiving Concomitant Vancomycin and Piperacillin-Tazobactam: Opportunities for Antimicrobial Stewardship
    Shigehiko Karino, Keith S. Kaye, Bhagyashri Navalkele, Bakht Nishan, Madiha Salim, Shantanu Solanki, Amina Pervaiz, Nader Tashtoush, Hamadullah Shaikh, Sunitha Koppula, Emily T. Martin, Ryan P. Mynatt, Kyle P. Murray, Michael J. Rybak, Jason M. Pogue

Pharmacology

  • Open Access
    Pharmacology
    Antitrypanosomal Activities and Mechanisms of Action of Novel Tetracyclic Iridoids from Morinda lucida Benth.
    Kofi D. Kwofie, Nguyen Huu Tung, Mitsuko Suzuki-Ohashi, Michael Amoa-Bosompem, Richard Adegle, Maxwell M. Sakyiamah, Frederick Ayertey, Kofi Baffour-Awuah Owusu, Isaac Tuffour, Philip Atchoglo, Kwadwo K. Frempong, William K. Anyan, Takuhiro Uto, Osamu Morinaga, Taizo Yamashita, Frederic Aboagye, Alfred A. Appiah, Regina Appiah-Opong, Alexander K. Nyarko, Yasuchika Yamaguchi, Dominic Edoh, Kwadwo A. Koram, Shoji Yamaoka, Daniel A. Boakye, Nobuo Ohta, Yukihiro Shoyama, Irene Ayi
  • Pharmacology
    Urinary Concentrations and Antibacterial Activity of BAL30072, a Novel Siderophore Monosulfactam, against Uropathogens after Intravenous Administration in Healthy Subjects
    Marion Straubinger, Holger Blenk, Kurt G. Naber, Florian M. E. Wagenlehner
  • Pharmacology
    In Vitro Activity of Quaternary Ammonium Surfactants against Streptococcal, Chlamydial, and Gonococcal Infective Agents
    Ângela S. Inácio, Alexandra Nunes, Catarina Milho, Luís Jaime Mota, Maria J. Borrego, João P. Gomes, Winchil L. C. Vaz, Otília V. Vieira
  • Pharmacology
    Inhibitory Potential of Antifungal Drugs on ATP-Binding Cassette Transporters P-Glycoprotein, MRP1 to MRP5, BCRP, and BSEP
    Vincent J. C. Lempers, Jeroen J. M. W. van den Heuvel, Frans G. M. Russel, Rob E. Aarnoutse, David M. Burger, Roger J. Brüggemann, Jan B. Koenderink
  • Pharmacology
    Assessing Predictive Performance of Published Population Pharmacokinetic Models of Intravenous Tobramycin in Pediatric Patients
    Celeste Bloomfield, Christine E. Staatz, Sean Unwin, Stefanie Hennig
  • Pharmacology
    Evaluating the Effects of Surotomycin Treatment on Clostridium difficile Toxin A and B Production, Immune Response, and Morphological Changes
    Bradley T. Endres, Eugénie Bassères, Mohammed Khaleduzzaman, M. Jahangir Alam, Laurent Chesnel, Kevin W. Garey
  • Pharmacology
    Pilot Study of the Pharmacokinetics of Cefotaxime in Critically Ill Patients with Acute Kidney Injury Treated with Continuous Renal Replacement Therapy
    Joost B. Koedijk, Corinne G. H. Valk-Swinkels, Tom A. Rijpstra, Daan J. Touw, Paul G. H. Mulder, Peter H. J. van der Voort, Nils E. van 't Veer, Nardo J. M. van der Meer
  • Pharmacology
    Single- and Repeated-Dose Pharmacokinetics of Ceftaroline in Plasma and Soft Tissues of Healthy Volunteers for Two Different Dosing Regimens of Ceftaroline Fosamil
    Peter Matzneller, Edith Lackner, Heimo Lagler, Beatrix Wulkersdorfer, Zoe Österreicher, Markus Zeitlinger
  • Pharmacology
    Clarithromycin Leads to Long-Term Survival and Cost Benefit in Ventilator-Associated Pneumonia and Sepsis
    Thomas Tsaganos, Maria Raftogiannis, Maria Pratikaki, Sofia Christodoulou, Anastasia Kotanidou, Evangelos Papadomichelakis, Apostolos Armaganidis, Christina Routsi, Evangelos J. Giamarellos-Bourboulis
  • Pharmacology
    Clomipramine and Benznidazole Act Synergistically and Ameliorate the Outcome of Experimental Chagas Disease
    Mónica Cristina García, Nicolás Eric Ponce, Liliana Maria Sanmarco, Rubén Hilario Manzo, Alvaro Federico Jimenez-Kairuz, Maria Pilar Aoki
  • Pharmacology
    Combination Pod-Intravaginal Ring Delivers Antiretroviral Agents for HIV Prophylaxis: Pharmacokinetic Evaluation in an Ovine Model
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    Emergence of the Plasmid-Mediated mcr-1 Gene in Colistin-Resistant Enterobacter aerogenes and Enterobacter cloacae
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    dfrA thyA Double Deletion in para-Aminosalicylic Acid-Resistant Mycobacterium tuberculosis Beijing Strains
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    Erratum for Alberti et al., Antimicrobial Susceptibilities of Abiotrophia defectiva, Granulicatella adiacens, and Granulicatella elegans
    Michael O. Alberti, Janet A. Hindler, Romney M. Humphries

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Antimicrobial Agents and Chemotherapy: 60 (6)

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volume 60, issue 6
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  • Commentary
  • Challenging Clinical Case in Antimicrobial Resistance
  • Chemistry; Biosynthesis
  • Mechanisms of Action: Physiological Effects
  • Mechanisms of Resistance
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  • Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity Against SARS-CoV-2
  • Mechanism-of-Action Classification of Antibiotics by Global Transcriptome Profiling
  • Fact versus Fiction: a Review of the Evidence behind Alcohol and Antibiotic Interactions
  • Povidone Iodine: Properties, Mechanisms of Action, and Role in Infection Control and Staphylococcus aureus Decolonization
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