Skip to main content
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My alerts
  • My Cart

Main menu

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • COVID-19 Special Collection
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About AAC
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • AAC Podcast
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My alerts
  • My Cart

Search

  • Advanced search
Antimicrobial Agents and Chemotherapy
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • COVID-19 Special Collection
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About AAC
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • AAC Podcast
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
Analytical Procedures

Effect of Fidaxomicin versus Vancomycin on Susceptibility to Intestinal Colonization with Vancomycin-Resistant Enterococci and Klebsiella pneumoniae in Mice

Abhishek Deshpande, Kelly Hurless, Jennifer L. Cadnum, Laurent Chesnel, Lihong Gao, Luisa Chan, Sirisha Kundrapu, Alexander Polinkovsky, Curtis J. Donskey
Abhishek Deshpande
aDepartment of Infectious Diseases, Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA
bDepartment of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kelly Hurless
bDepartment of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jennifer L. Cadnum
bDepartment of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Laurent Chesnel
cMerck and Co., Inc., Kenilworth, New Jersey, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lihong Gao
cMerck and Co., Inc., Kenilworth, New Jersey, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Luisa Chan
dSecond Genome, Inc., San Bruno, California, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sirisha Kundrapu
bDepartment of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alexander Polinkovsky
bDepartment of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Curtis J. Donskey
bDepartment of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
eGeriatric Research, Education and Clinical Center, Cleveland VA Medical Center, Cleveland, Ohio, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1128/AAC.02590-15
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Figures

  • FIG 1
    • Open in new tab
    • Download powerpoint
    FIG 1

    Effect of antibiotic treatment on the concentrations of enterococci (A) and aerobic and facultative Gram-negative bacilli (B) in stool by culture. Mice received daily oral antibiotic treatment for 5 days. The error bars represent the standard error. *, P < 0.05.

  • FIG 2
    • Open in new tab
    • Download powerpoint
    FIG 2

    Comparison of stool microbiota of mice by 16S deep-sequencing analysis after 5 days of antibiotic treatment. The relative abundances of the major bacterial phyla are shown. Numbers indicate data for individual mice in each group.

  • FIG 3
    • Open in new tab
    • Download powerpoint
    FIG 3

    Comparison of stool microbiota of mice by 16S deep-sequencing analysis before, during, and after treatment with oral fidaxomicin or vancomycin. Mice received daily oral antibiotic treatment for 5 days (day 0 to day 5). Numbers indicate day of sample collection: day 0, prior to treatment; day 5, after 5 days of antibiotic treatment; day 10, 5 days after last antibiotic dose; and day 15, 10 days after last antibiotic dose. The relative abundances of the major bacterial phyla are shown as a composite of five total mice in each group at each time point.

  • FIG 4
    • Open in new tab
    • Download powerpoint
    FIG 4

    Effect of antibiotic treatment on establishment of colonization by VRE (A) and ESBL-Kp (B) in mice. Mice received daily oral antibiotic treatment for 5 days. The pathogens were administered orally on day 2 of antibiotic treatment. The error bars represent the standard error.

  • FIG 5
    • Open in new tab
    • Download powerpoint
    FIG 5

    Effect of antibiotic treatment on establishment of colonization by VRE in mice. Mice received daily oral antibiotic treatment for 5 days. The pathogens were administered orally on day 2 of antibiotic treatment. The error bars represent the standard error.

PreviousNext
Back to top
Download PDF
Citation Tools
Effect of Fidaxomicin versus Vancomycin on Susceptibility to Intestinal Colonization with Vancomycin-Resistant Enterococci and Klebsiella pneumoniae in Mice
Abhishek Deshpande, Kelly Hurless, Jennifer L. Cadnum, Laurent Chesnel, Lihong Gao, Luisa Chan, Sirisha Kundrapu, Alexander Polinkovsky, Curtis J. Donskey
Antimicrobial Agents and Chemotherapy Jun 2016, 60 (7) 3988-3993; DOI: 10.1128/AAC.02590-15

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Print

Alerts
Sign In to Email Alerts with your Email Address
Email

Thank you for sharing this Antimicrobial Agents and Chemotherapy article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Effect of Fidaxomicin versus Vancomycin on Susceptibility to Intestinal Colonization with Vancomycin-Resistant Enterococci and Klebsiella pneumoniae in Mice
(Your Name) has forwarded a page to you from Antimicrobial Agents and Chemotherapy
(Your Name) thought you would be interested in this article in Antimicrobial Agents and Chemotherapy.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Effect of Fidaxomicin versus Vancomycin on Susceptibility to Intestinal Colonization with Vancomycin-Resistant Enterococci and Klebsiella pneumoniae in Mice
Abhishek Deshpande, Kelly Hurless, Jennifer L. Cadnum, Laurent Chesnel, Lihong Gao, Luisa Chan, Sirisha Kundrapu, Alexander Polinkovsky, Curtis J. Donskey
Antimicrobial Agents and Chemotherapy Jun 2016, 60 (7) 3988-3993; DOI: 10.1128/AAC.02590-15
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Top
  • Article
    • ABSTRACT
    • INTRODUCTION
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

Cited By...

About

  • About AAC
  • Editor in Chief
  • Editorial Board
  • Policies
  • For Reviewers
  • For the Media
  • For Librarians
  • For Advertisers
  • Alerts
  • AAC Podcast
  • RSS
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • ASM Author Center
  • Submit a Manuscript
  • Article Types
  • Ethics
  • Contact Us

Follow #AACJournal

@ASMicrobiology

       

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

 

American Society for Microbiology
1752 N St. NW
Washington, DC 20036
Phone: (202) 737-3600

Copyright © 2021 American Society for Microbiology | Privacy Policy | Website feedback

Print ISSN: 0066-4804; Online ISSN: 1098-6596