First Description of mcr-1-Mediated Colistin Resistance in Human Infections Caused by Escherichia coli in Latin America

DOI: 10.1128/AAC.00573-16

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TABLE 1

Characteristics of mcr-1-harboring E. coli isolates

Characteristic	E. coli isolate:									Salmonella sp. strain TC-M19736
Characteristic	M15049	M15224	M17059	M17056	M19241	M19242	M19441	M19736	M19855	Salmonella sp. strain TC-M19736
Isolation date	July 2012	Oct. 2012	Nov. 2013	Nov. 2013	Mar. 2015	Apr. 2015	July 2015	Nov. 2015	Jan. 2016
Diagnostic/underlying disease of patient	Neurologic disease	Diabetes	Appendicitis	Urinary tract infection	Prostate cancer	Heart failure	Rheumatoid arthritis	Secondary peritonitis/colon cancer	NA^a
Isolation site	Blood	Urine	Abdomen	Blood	Urine (catheter)	Urine (catheter)	Bone	Blood	Abscess
Hospital	1	2	3	3	3	3	4	5	6
MIC (μg/ml)^b of:
Colistin	8	16	8	8	8	8	8	8	8	16
Polymyxin B	8	16	16	8	8	8	8	8	8	16
Additional resistance(s)^c	TET, TMS, CIP, FOS	AMP, FGC, NIT, MIN, TMS, CIP, FOS	AMP, AMS, FGC, ESC, GEN, MIN, CIP	AMP, CIP	CIP	AMP, AMS, FGC, ESC, TMS, GEN	AMP, AMS, FGC, ESC, CMP, GEN, MIN, CIP	AMP, AMS, CMP, CIP	AMP, AMS, FGC, ESC, GEN, MIN, CIP	None
ESBL^d genes	None	None	CTX-M-14 group	None	None	CTX-M-2 group	CTX-M-15 group	None	CTX-M-14 group

↵a NA, not available.
↵b Susceptibility to colistin and polymyxin B was evaluated by agar dilution.
↵c AMP, ampicillin; AMS, ampicillin-sulbactam; FGC, first-generation cephalosporins; ESC, extended-spectrum cephalosporins; TET, tetracycline; MIN, minocycline; TMS, trimethoprim-sulfamethoxazole; CIP, ciprofloxacin; FOS, fosfomycin; NIT, nitrofurantoin; GEN, gentamicin; CMP, chloramphenicol.
↵d ESBL, extended-spectrum β-lactamase.