The Redox Cycler Plasmodione Is a Fast-Acting Antimalarial Lead Compound with Pronounced Activity against Sexual and Early Asexual Blood-Stage Parasites

DOI: 10.1128/AAC.02975-15

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^aUMR 7509 CNRS and University of Strasbourg, European School of Chemistry, Polymers and Materials (ECPM), Strasbourg, France
^bCenter of Infectious Diseases, Parasitology, Heidelberg University, Heidelberg, Germany
^cMuseum National d'Histoire Naturelle, UMR 7245 CNRS, Paris Cedex 05, France
^dINSERM, U963, Strasbourg, France
^eCNRS, UPR9022, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France
^fUniversité de Strasbourg, Strasbourg, France
^gSRSMC Laboratory, UMR CNRS 7565, University of Lorraine, Metz, France
^hDepartment of Oncology, University of Torino Medical School, Turin, Italy
ⁱInstitut de Recherche Biomédicale des Armées, Département des Maladies Infectieuses, Unité de Parasitologie et d'Entomologie, Brétigny sur Orge, France
^jAix Marseille Université, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM 63, CNRS 7278, IRD 198, INSERM 1095, Marseille, France
^kCentre National de Référence du Paludisme, Marseille, France
^lGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany

Address correspondence to Elisabeth Davioud-Charvet, elisabeth.davioud{at}unistra.fr.
↵* Present address: Katharina Ehrhardt, INSERM U963/CNRS UPR9022, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France.
Citation Ehrhardt K, Deregnaucourt C, Goetz A-A, Tzanova T, Gallo V, Arese P, Pradines B, Adjalley SH, Bagrel D, Blandin S, Lanzer M, Davioud-Charvet E. 2016. The redox cycler plasmodione is a fast-acting antimalarial lead compound with pronounced activity against sexual and early asexual blood-stage parasites. Antimicrob Agents Chemother 60:5146–5158. doi:10.1128/AAC.02975-15.

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