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The Redox Cycler Plasmodione Is a Fast-Acting Antimalarial Lead Compound with Pronounced Activity against Sexual and Early Asexual Blood-Stage Parasites

Katharina Ehrhardt, Christiane Deregnaucourt, Alice-Anne Goetz, Tzvetomira Tzanova, Valentina Gallo, Paolo Arese, Bruno Pradines, Sophie H. Adjalley, Denyse Bagrel, Stephanie Blandin, Michael Lanzer, Elisabeth Davioud-Charvet
Katharina Ehrhardt
aUMR 7509 CNRS and University of Strasbourg, European School of Chemistry, Polymers and Materials (ECPM), Strasbourg, France
bCenter of Infectious Diseases, Parasitology, Heidelberg University, Heidelberg, Germany
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Christiane Deregnaucourt
cMuseum National d'Histoire Naturelle, UMR 7245 CNRS, Paris Cedex 05, France
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Alice-Anne Goetz
dINSERM, U963, Strasbourg, France
eCNRS, UPR9022, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France
fUniversité de Strasbourg, Strasbourg, France
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Tzvetomira Tzanova
gSRSMC Laboratory, UMR CNRS 7565, University of Lorraine, Metz, France
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Valentina Gallo
hDepartment of Oncology, University of Torino Medical School, Turin, Italy
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Paolo Arese
hDepartment of Oncology, University of Torino Medical School, Turin, Italy
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Bruno Pradines
iInstitut de Recherche Biomédicale des Armées, Département des Maladies Infectieuses, Unité de Parasitologie et d'Entomologie, Brétigny sur Orge, France
jAix Marseille Université, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM 63, CNRS 7278, IRD 198, INSERM 1095, Marseille, France
kCentre National de Référence du Paludisme, Marseille, France
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Sophie H. Adjalley
lGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
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Denyse Bagrel
gSRSMC Laboratory, UMR CNRS 7565, University of Lorraine, Metz, France
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Stephanie Blandin
dINSERM, U963, Strasbourg, France
eCNRS, UPR9022, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France
fUniversité de Strasbourg, Strasbourg, France
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Michael Lanzer
bCenter of Infectious Diseases, Parasitology, Heidelberg University, Heidelberg, Germany
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Elisabeth Davioud-Charvet
aUMR 7509 CNRS and University of Strasbourg, European School of Chemistry, Polymers and Materials (ECPM), Strasbourg, France
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  • ORCID record for Elisabeth Davioud-Charvet
DOI: 10.1128/AAC.02975-15
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Article Information

DOI 
https://doi.org/10.1128/AAC.02975-15
PubMed 
27297478

Published By 
American Society for Microbiology Journals
History 
  • Received December 13, 2015
  • Returned for modification February 24, 2016
  • Accepted May 27, 2016
  • Published online August 22, 2016.

Copyright & Usage 
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (June 13, 2016).
  • You are viewing the most recent version of this article.

Author Information

  1. Katharina Ehrhardta,b*,
  2. Christiane Deregnaucourtc,
  3. Alice-Anne Goetzd,e,f,
  4. Tzvetomira Tzanovag,
  5. Valentina Galloh,
  6. Paolo Areseh,
  7. Bruno Pradinesi,j,k,
  8. Sophie H. Adjalleyl,
  9. Denyse Bagrelg,
  10. Stephanie Blandind,e,f,
  11. Michael Lanzerb and
  12. Elisabeth Davioud-Charveta
  1. aUMR 7509 CNRS and University of Strasbourg, European School of Chemistry, Polymers and Materials (ECPM), Strasbourg, France
  2. bCenter of Infectious Diseases, Parasitology, Heidelberg University, Heidelberg, Germany
  3. cMuseum National d'Histoire Naturelle, UMR 7245 CNRS, Paris Cedex 05, France
  4. dINSERM, U963, Strasbourg, France
  5. eCNRS, UPR9022, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France
  6. fUniversité de Strasbourg, Strasbourg, France
  7. gSRSMC Laboratory, UMR CNRS 7565, University of Lorraine, Metz, France
  8. hDepartment of Oncology, University of Torino Medical School, Turin, Italy
  9. iInstitut de Recherche Biomédicale des Armées, Département des Maladies Infectieuses, Unité de Parasitologie et d'Entomologie, Brétigny sur Orge, France
  10. jAix Marseille Université, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM 63, CNRS 7278, IRD 198, INSERM 1095, Marseille, France
  11. kCentre National de Référence du Paludisme, Marseille, France
  12. lGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
  • Address correspondence to Elisabeth Davioud-Charvet, elisabeth.davioud{at}unistra.fr.
  • ↵* Present address: Katharina Ehrhardt, INSERM U963/CNRS UPR9022, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France.

  • Citation Ehrhardt K, Deregnaucourt C, Goetz A-A, Tzanova T, Gallo V, Arese P, Pradines B, Adjalley SH, Bagrel D, Blandin S, Lanzer M, Davioud-Charvet E. 2016. The redox cycler plasmodione is a fast-acting antimalarial lead compound with pronounced activity against sexual and early asexual blood-stage parasites. Antimicrob Agents Chemother 60:5146–5158. doi:10.1128/AAC.02975-15.

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The Redox Cycler Plasmodione Is a Fast-Acting Antimalarial Lead Compound with Pronounced Activity against Sexual and Early Asexual Blood-Stage Parasites
Katharina Ehrhardt, Christiane Deregnaucourt, Alice-Anne Goetz, Tzvetomira Tzanova, Valentina Gallo, Paolo Arese, Bruno Pradines, Sophie H. Adjalley, Denyse Bagrel, Stephanie Blandin, Michael Lanzer, Elisabeth Davioud-Charvet
Antimicrobial Agents and Chemotherapy Aug 2016, 60 (9) 5146-5158; DOI: 10.1128/AAC.02975-15

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The Redox Cycler Plasmodione Is a Fast-Acting Antimalarial Lead Compound with Pronounced Activity against Sexual and Early Asexual Blood-Stage Parasites
Katharina Ehrhardt, Christiane Deregnaucourt, Alice-Anne Goetz, Tzvetomira Tzanova, Valentina Gallo, Paolo Arese, Bruno Pradines, Sophie H. Adjalley, Denyse Bagrel, Stephanie Blandin, Michael Lanzer, Elisabeth Davioud-Charvet
Antimicrobial Agents and Chemotherapy Aug 2016, 60 (9) 5146-5158; DOI: 10.1128/AAC.02975-15
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