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Antiviral Agents

Prophylactic Efficacy of Quercetin 3-β-O-d-Glucoside against Ebola Virus Infection

Xiangguo Qiu, Andrea Kroeker, Shihua He, Robert Kozak, Jonathan Audet, Majambu Mbikay, Michel Chrétien
Xiangguo Qiu
aSpecial Pathogens Program, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
bDepartment of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
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Andrea Kroeker
aSpecial Pathogens Program, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
bDepartment of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
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Shihua He
aSpecial Pathogens Program, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
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Robert Kozak
aSpecial Pathogens Program, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
bDepartment of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
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Jonathan Audet
aSpecial Pathogens Program, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
bDepartment of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
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Majambu Mbikay
cFunctional Endoproteolysis Laboratory, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
dChronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
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Michel Chrétien
cFunctional Endoproteolysis Laboratory, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
dChronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
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DOI: 10.1128/AAC.00307-16
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ABSTRACT

Ebola outbreaks occur on a frequent basis, with the 2014-2015 outbreak in West Africa being the largest one ever recorded. This outbreak has resulted in over 11,000 deaths in four African countries and has received international attention and intervention. Although there are currently no approved therapies or vaccines, many promising candidates are undergoing clinical trials, and several have had success in promoting recovery from Ebola. However, these prophylactics and therapeutics have been designed and tested only against the same species of Ebola virus as the one causing the current outbreak. Future outbreaks involving other species would require reformulation and possibly redevelopment. Therefore, a broad-spectrum alternative is highly desirable. We have found that a flavonoid derivative called quercetin 3-β-O-d-glucoside (Q3G) has the ability to protect mice from Ebola even when given as little as 30 min prior to infection. Furthermore, we have demonstrated that this compound targets the early steps of viral entry. Most promisingly, antiviral activity against two distinct species of Ebola virus was seen. This study serves as a proof of principle that Q3G has potential as a prophylactic against Ebola virus infection.

FOOTNOTES

    • Received 5 February 2016.
    • Returned for modification 24 February 2016.
    • Accepted 7 June 2016.
    • Accepted manuscript posted online 13 June 2016.
  • Supplemental material for this article may be found at http://dx.doi.org/10.1128/AAC.00307-16.

  • Copyright © 2016, American Society for Microbiology. All Rights Reserved.
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Prophylactic Efficacy of Quercetin 3-β-O-d-Glucoside against Ebola Virus Infection
Xiangguo Qiu, Andrea Kroeker, Shihua He, Robert Kozak, Jonathan Audet, Majambu Mbikay, Michel Chrétien
Antimicrobial Agents and Chemotherapy Aug 2016, 60 (9) 5182-5188; DOI: 10.1128/AAC.00307-16

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Prophylactic Efficacy of Quercetin 3-β-O-d-Glucoside against Ebola Virus Infection
Xiangguo Qiu, Andrea Kroeker, Shihua He, Robert Kozak, Jonathan Audet, Majambu Mbikay, Michel Chrétien
Antimicrobial Agents and Chemotherapy Aug 2016, 60 (9) 5182-5188; DOI: 10.1128/AAC.00307-16
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