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Experimental Therapeutics

Unraveling Drug Penetration of Echinocandin Antifungals at the Site of Infection in an Intra-abdominal Abscess Model

Yanan Zhao, Brendan Prideaux, Yoji Nagasaki, Min Hee Lee, Pei-Yu Chen, Landry Blanc, Hsinpin Ho, Cornelius J. Clancy, Minh Hong Nguyen, Véronique Dartois, David S. Perlin
Yanan Zhao
aPublic Health Research Institute, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA
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Brendan Prideaux
aPublic Health Research Institute, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA
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Yoji Nagasaki
aPublic Health Research Institute, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA
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Min Hee Lee
aPublic Health Research Institute, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA
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Pei-Yu Chen
aPublic Health Research Institute, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA
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Landry Blanc
aPublic Health Research Institute, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA
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Hsinpin Ho
aPublic Health Research Institute, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA
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Cornelius J. Clancy
bDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
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Minh Hong Nguyen
bDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
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Véronique Dartois
aPublic Health Research Institute, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA
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David S. Perlin
aPublic Health Research Institute, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA
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DOI: 10.1128/AAC.01009-17
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Article Information

DOI 
https://doi.org/10.1128/AAC.01009-17
PubMed 
28739797

Published By 
American Society for Microbiology Journals
History 
  • Received May 15, 2017
  • Returned for modification June 20, 2017
  • Accepted July 19, 2017
  • Published online September 22, 2017.

Copyright & Usage 
Copyright © 2017 Zhao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license .

Article Versions

  • Accepted Manuscript version (July 24, 2017).
  • You are viewing the most recent version of this article.

Author Information

  1. Yanan Zhaoa,
  2. Brendan Prideauxa,
  3. Yoji Nagasakia,
  4. Min Hee Leea,
  5. Pei-Yu Chena,
  6. Landry Blanca,
  7. Hsinpin Hoa,
  8. Cornelius J. Clancyb,
  9. Minh Hong Nguyenb,
  10. Véronique Dartoisa and
  11. David S. Perlina
  1. aPublic Health Research Institute, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA
  2. bDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
  • Address correspondence to Yanan Zhao, zhaoy1{at}njms.rutgers.edu, or David S. Perlin, perlinds{at}njms.rutgers.edu.
  • Y.Z. and B.P. contributed equally to this work.

  • Citation Zhao Y, Prideaux B, Nagasaki Y, Lee MH, Chen P-Y, Blanc L, Ho H, Clancy CJ, Nguyen MH, Dartois V, Perlin DS. 2017. Unraveling drug penetration of echinocandin antifungals at the site of infection in an intra-abdominal abscess model. Antimicrob Agents Chemother 61:e01009-17. https://doi.org/10.1128/AAC.01009-17 .

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Unraveling Drug Penetration of Echinocandin Antifungals at the Site of Infection in an Intra-abdominal Abscess Model
Yanan Zhao, Brendan Prideaux, Yoji Nagasaki, Min Hee Lee, Pei-Yu Chen, Landry Blanc, Hsinpin Ho, Cornelius J. Clancy, Minh Hong Nguyen, Véronique Dartois, David S. Perlin
Antimicrobial Agents and Chemotherapy Sep 2017, 61 (10) e01009-17; DOI: 10.1128/AAC.01009-17

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Unraveling Drug Penetration of Echinocandin Antifungals at the Site of Infection in an Intra-abdominal Abscess Model
Yanan Zhao, Brendan Prideaux, Yoji Nagasaki, Min Hee Lee, Pei-Yu Chen, Landry Blanc, Hsinpin Ho, Cornelius J. Clancy, Minh Hong Nguyen, Véronique Dartois, David S. Perlin
Antimicrobial Agents and Chemotherapy Sep 2017, 61 (10) e01009-17; DOI: 10.1128/AAC.01009-17
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KEYWORDS

Abdominal Abscess
antifungal agents
Candida albicans
candidiasis
echinocandins
lipopeptides
intra-abdominal candidiasis
echinocandin
drug penetration
matrix-assisted desorption ionization (MALDI) mass spectrometry imaging

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