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Experimental Therapeutics

Reducing Antibacterial Development Risk for GSK1322322 by Exploring Potential Human Dose Regimens in Nonclinical Efficacy Studies Using Immunocompetent Rats

Jennifer L. Hoover, Christine M. Singley, Philippa Elefante, Peter DeMarsh, Magdalena Zalacain, Stephen Rittenhouse
Jennifer L. Hoover
GlaxoSmithKline, Collegeville, Pennsylvania, USA
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Christine M. Singley
GlaxoSmithKline, Collegeville, Pennsylvania, USA
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Philippa Elefante
GlaxoSmithKline, Collegeville, Pennsylvania, USA
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Peter DeMarsh
GlaxoSmithKline, Collegeville, Pennsylvania, USA
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Magdalena Zalacain
GlaxoSmithKline, Collegeville, Pennsylvania, USA
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Stephen Rittenhouse
GlaxoSmithKline, Collegeville, Pennsylvania, USA
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DOI: 10.1128/AAC.00959-17
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Article Information

DOI 
https://doi.org/10.1128/AAC.00959-17
PubMed 
28807913

Published By 
American Society for Microbiology Journals
History 
  • Received May 8, 2017
  • Returned for modification June 9, 2017
  • Accepted August 8, 2017
  • Published online October 24, 2017.

Copyright & Usage 
Copyright © 2017 Hoover et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license .

Article Versions

  • Accepted Manuscript version (August 14, 2017).
  • You are viewing the most recent version of this article.

Author Information

  1. Jennifer L. Hoover,
  2. Christine M. Singley,
  3. Philippa Elefante,
  4. Peter DeMarsh,
  5. Magdalena Zalacain and
  6. Stephen Rittenhouse
  1. GlaxoSmithKline, Collegeville, Pennsylvania, USA
  • Address correspondence to Jennifer L. Hoover, jennifer.l.hoover{at}gsk.com.
  • Citation Hoover JL, Singley CM, Elefante P, DeMarsh P, Zalacain M, Rittenhouse S. 2017. Reducing antibacterial development risk for GSK1322322 by exploring potential human dose regimens in nonclinical efficacy studies using immunocompetent rats. Antimicrob Agents Chemother 61:e00959-17. https://doi.org/10.1128/AAC.00959-17 .

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Reducing Antibacterial Development Risk for GSK1322322 by Exploring Potential Human Dose Regimens in Nonclinical Efficacy Studies Using Immunocompetent Rats
Jennifer L. Hoover, Christine M. Singley, Philippa Elefante, Peter DeMarsh, Magdalena Zalacain, Stephen Rittenhouse
Antimicrobial Agents and Chemotherapy Oct 2017, 61 (11) e00959-17; DOI: 10.1128/AAC.00959-17

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Reducing Antibacterial Development Risk for GSK1322322 by Exploring Potential Human Dose Regimens in Nonclinical Efficacy Studies Using Immunocompetent Rats
Jennifer L. Hoover, Christine M. Singley, Philippa Elefante, Peter DeMarsh, Magdalena Zalacain, Stephen Rittenhouse
Antimicrobial Agents and Chemotherapy Oct 2017, 61 (11) e00959-17; DOI: 10.1128/AAC.00959-17
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KEYWORDS

Anti-Bacterial Agents
Bridged Bicyclo Compounds, Heterocyclic
Haemophilus influenzae
Hydroxamic Acids
Staphylococcus aureus
Streptococcus pneumoniae
animal model
antibacterial agents
pharmacokinetics
dose optimization
humanized pharmacokinetic profiles
peptide deformylase
dose selection

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