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Mechanisms of Action: Physiological Effects

Hyperbaric Oxygen Sensitizes Anoxic Pseudomonas aeruginosa Biofilm to Ciprofloxacin

Mette Kolpen, Christian J. Lerche, Kasper N. Kragh, Thomas Sams, Klaus Koren, Anna S. Jensen, Laura Line, Thomas Bjarnsholt, Oana Ciofu, Claus Moser, Michael Kühl, Niels Høiby, Peter Ø. Jensen
Mette Kolpen
aDepartment of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark
bDepartment of Immunology and Microbiology, Costerton Biofilm Center, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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  • ORCID record for Mette Kolpen
Christian J. Lerche
aDepartment of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark
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Kasper N. Kragh
bDepartment of Immunology and Microbiology, Costerton Biofilm Center, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Thomas Sams
cBiomedical Engineering, Department of Electrical Engineering, Technical University of Denmark, Lyngby, Denmark
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Klaus Koren
dMarine Biological Section, Department of Biology, University of Copenhagen, Helsingør, Denmark
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Anna S. Jensen
cBiomedical Engineering, Department of Electrical Engineering, Technical University of Denmark, Lyngby, Denmark
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Laura Line
aDepartment of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark
bDepartment of Immunology and Microbiology, Costerton Biofilm Center, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Thomas Bjarnsholt
aDepartment of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark
bDepartment of Immunology and Microbiology, Costerton Biofilm Center, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Oana Ciofu
bDepartment of Immunology and Microbiology, Costerton Biofilm Center, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Claus Moser
aDepartment of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark
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Michael Kühl
dMarine Biological Section, Department of Biology, University of Copenhagen, Helsingør, Denmark
eClimate Change Cluster, University of Technology Sydney, Sydney, Australia
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Niels Høiby
aDepartment of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark
bDepartment of Immunology and Microbiology, Costerton Biofilm Center, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Peter Ø. Jensen
aDepartment of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark
bDepartment of Immunology and Microbiology, Costerton Biofilm Center, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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DOI: 10.1128/AAC.01024-17
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Article Information

DOI 
https://doi.org/10.1128/AAC.01024-17
PubMed 
28874373

Published By 
American Society for Microbiology Journals
History 
  • Received May 17, 2017
  • Returned for modification June 8, 2017
  • Accepted August 22, 2017
  • Published online October 24, 2017.

Copyright & Usage 
Copyright © 2017 Kolpen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license .

Article Versions

  • Accepted Manuscript version (September 05, 2017).
  • You are viewing the most recent version of this article.

Author Information

  1. Mette Kolpena,b,
  2. Christian J. Lerchea,
  3. Kasper N. Kraghb,
  4. Thomas Samsc,
  5. Klaus Korend,
  6. Anna S. Jensenc,
  7. Laura Linea,b,
  8. Thomas Bjarnsholta,b,
  9. Oana Ciofub,
  10. Claus Mosera,
  11. Michael Kühld,e,
  12. Niels Høibya,b and
  13. Peter Ø. Jensena,b
  1. aDepartment of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark
  2. bDepartment of Immunology and Microbiology, Costerton Biofilm Center, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  3. cBiomedical Engineering, Department of Electrical Engineering, Technical University of Denmark, Lyngby, Denmark
  4. dMarine Biological Section, Department of Biology, University of Copenhagen, Helsingør, Denmark
  5. eClimate Change Cluster, University of Technology Sydney, Sydney, Australia
  • Address correspondence to Mette Kolpen, mette.kolpen{at}regionh.dk, or Peter Ø. Jensen, peter.oestrup.jensen{at}regionh.dk.
  • Citation Kolpen M, Lerche CJ, Kragh KN, Sams T, Koren K, Jensen AS, Line L, Bjarnsholt T, Ciofu O, Moser C, Kühl M, Høiby N, Jensen PØ. 2017. Hyperbaric oxygen sensitizes anoxic Pseudomonas aeruginosa biofilm to ciprofloxacin. Antimicrob Agents Chemother 61:e01024-17. https://doi.org/10.1128/AAC.01024-17 .

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Hyperbaric Oxygen Sensitizes Anoxic Pseudomonas aeruginosa Biofilm to Ciprofloxacin
Mette Kolpen, Christian J. Lerche, Kasper N. Kragh, Thomas Sams, Klaus Koren, Anna S. Jensen, Laura Line, Thomas Bjarnsholt, Oana Ciofu, Claus Moser, Michael Kühl, Niels Høiby, Peter Ø. Jensen
Antimicrobial Agents and Chemotherapy Oct 2017, 61 (11) e01024-17; DOI: 10.1128/AAC.01024-17

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Hyperbaric Oxygen Sensitizes Anoxic Pseudomonas aeruginosa Biofilm to Ciprofloxacin
Mette Kolpen, Christian J. Lerche, Kasper N. Kragh, Thomas Sams, Klaus Koren, Anna S. Jensen, Laura Line, Thomas Bjarnsholt, Oana Ciofu, Claus Moser, Michael Kühl, Niels Høiby, Peter Ø. Jensen
Antimicrobial Agents and Chemotherapy Oct 2017, 61 (11) e01024-17; DOI: 10.1128/AAC.01024-17
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KEYWORDS

biofilms
ciprofloxacin
Hyperbaric Oxygenation
Pseudomonas aeruginosa
biofilms
ciprofloxacin
hyperbaric oxygen
oxygen radicals
Pseudomonas aeruginosa

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