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Chemistry; Biosynthesis

N-Acetylglucosamine-1-Phosphate Transferase, WecA, as a Validated Drug Target in Mycobacterium tuberculosis

Stanislav Huszár, Vinayak Singh, Alica Polčicová, Peter Baráth, María Belén Barrio, Sophie Lagrange, Véronique Leblanc, Carol A. Nacy, Valerie Mizrahi, Katarína Mikušová
Stanislav Huszár
aComenius University in Bratislava, Faculty of Natural Sciences, Department of Biochemistry, Bratislava, Slovakia
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Vinayak Singh
bMRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine and Division of Medical Microbiology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
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Alica Polčicová
aComenius University in Bratislava, Faculty of Natural Sciences, Department of Biochemistry, Bratislava, Slovakia
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Peter Baráth
dInstitute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia
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María Belén Barrio
cInfectious Disease Therapeutic Strategic Unit, Sanofi R&D, Toulouse, France
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Sophie Lagrange
cInfectious Disease Therapeutic Strategic Unit, Sanofi R&D, Toulouse, France
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Véronique Leblanc
cInfectious Disease Therapeutic Strategic Unit, Sanofi R&D, Toulouse, France
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Carol A. Nacy
eSequella, Inc., Rockville, Maryland, USA
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Valerie Mizrahi
bMRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine and Division of Medical Microbiology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
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Katarína Mikušová
aComenius University in Bratislava, Faculty of Natural Sciences, Department of Biochemistry, Bratislava, Slovakia
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DOI: 10.1128/AAC.01310-17
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Article Information

DOI 
https://doi.org/10.1128/AAC.01310-17
PubMed 
28874370

Published By 
American Society for Microbiology Journals
History 
  • Received June 24, 2017
  • Returned for modification August 15, 2017
  • Accepted August 25, 2017
  • Published online October 24, 2017.

Copyright & Usage 
Copyright © 2017 American Society for Microbiology. All Rights Reserved .

Article Versions

  • Accepted Manuscript version (September 05, 2017).
  • You are viewing the most recent version of this article.

Author Information

  1. Stanislav Huszára,
  2. Vinayak Singhb*,
  3. Alica Polčicováa,
  4. Peter Baráthd,
  5. María Belén Barrioc,
  6. Sophie Lagrangec,
  7. Véronique Leblancc,
  8. Carol A. Nacye,
  9. Valerie Mizrahib and
  10. Katarína Mikušováa
  1. aComenius University in Bratislava, Faculty of Natural Sciences, Department of Biochemistry, Bratislava, Slovakia
  2. bMRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine and Division of Medical Microbiology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
  3. cInfectious Disease Therapeutic Strategic Unit, Sanofi R&D, Toulouse, France
  4. dInstitute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia
  5. eSequella, Inc., Rockville, Maryland, USA
  • Address correspondence to Valerie Mizrahi, valerie.mizrahi{at}uct.ac.za, or Katarína Mikušová, katarina.mikusova{at}uniba.sk.
  • ↵* Present address: Vinayak Singh, H3D Drug Discovery and Development Centre, Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, Cape Town, South Africa.

  • S. H. and V.S. contributed equally to this work.

  • Citation Huszár S, Singh V, Polčicová A, Baráth P, Barrio MB, Lagrange S, Leblanc V, Nacy CA, Mizrahi V, Mikušová K. 2017. N-Acetylglucosamine-1-phosphate transferase, WecA, as a validated drug target in Mycobacterium tuberculosis. Antimicrob Agents Chemother 61:e01310-17. https://doi.org/10.1128/AAC.01310-17 .

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N-Acetylglucosamine-1-Phosphate Transferase, WecA, as a Validated Drug Target in Mycobacterium tuberculosis
Stanislav Huszár, Vinayak Singh, Alica Polčicová, Peter Baráth, María Belén Barrio, Sophie Lagrange, Véronique Leblanc, Carol A. Nacy, Valerie Mizrahi, Katarína Mikušová
Antimicrobial Agents and Chemotherapy Oct 2017, 61 (11) e01310-17; DOI: 10.1128/AAC.01310-17

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N-Acetylglucosamine-1-Phosphate Transferase, WecA, as a Validated Drug Target in Mycobacterium tuberculosis
Stanislav Huszár, Vinayak Singh, Alica Polčicová, Peter Baráth, María Belén Barrio, Sophie Lagrange, Véronique Leblanc, Carol A. Nacy, Valerie Mizrahi, Katarína Mikušová
Antimicrobial Agents and Chemotherapy Oct 2017, 61 (11) e01310-17; DOI: 10.1128/AAC.01310-17
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KEYWORDS

antitubercular agents
Mycobacterium tuberculosis
Transferases (Other Substituted Phosphate Groups)
cell wall
drug targets
tuberculosis

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