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Mechanisms of Resistance

Amino Acid Substitution in the Major Multidrug Efflux Transporter Protein AcrB Contributes to Low Susceptibility to Azithromycin in Haemophilus influenzae

Shoji Seyama, Takeaki Wajima, Hidemasa Nakaminami, Norihisa Noguchi
Shoji Seyama
Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
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Takeaki Wajima
Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
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Hidemasa Nakaminami
Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
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Norihisa Noguchi
Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
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DOI: 10.1128/AAC.01337-17
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Article Information

DOI 
https://doi.org/10.1128/AAC.01337-17
PubMed 
28848006

Published By 
American Society for Microbiology Journals
History 
  • Received June 29, 2017
  • Returned for modification July 23, 2017
  • Accepted August 10, 2017
  • Published online October 24, 2017.

Copyright & Usage 
Copyright © 2017 American Society for Microbiology. All Rights Reserved .

Article Versions

  • Accepted Manuscript version (August 28, 2017).
  • You are viewing the most recent version of this article.

Author Information

  1. Shoji Seyama,
  2. Takeaki Wajima,
  3. Hidemasa Nakaminami and
  4. Norihisa Noguchi
  1. Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
  • Address correspondence to Norihisa Noguchi, noguchin{at}toyaku.ac.jp.
  • Citation Seyama S, Wajima T, Nakaminami H, Noguchi N. 2017. Amino acid substitution in the major multidrug efflux transporter protein AcrB contributes to low susceptibility to azithromycin in Haemophilus influenzae. Antimicrob Agents Chemother 61:e01337-17. https://doi.org/10.1128/AAC.01337-17 .

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Amino Acid Substitution in the Major Multidrug Efflux Transporter Protein AcrB Contributes to Low Susceptibility to Azithromycin in Haemophilus influenzae
Shoji Seyama, Takeaki Wajima, Hidemasa Nakaminami, Norihisa Noguchi
Antimicrobial Agents and Chemotherapy Oct 2017, 61 (11) e01337-17; DOI: 10.1128/AAC.01337-17

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Amino Acid Substitution in the Major Multidrug Efflux Transporter Protein AcrB Contributes to Low Susceptibility to Azithromycin in Haemophilus influenzae
Shoji Seyama, Takeaki Wajima, Hidemasa Nakaminami, Norihisa Noguchi
Antimicrobial Agents and Chemotherapy Oct 2017, 61 (11) e01337-17; DOI: 10.1128/AAC.01337-17
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KEYWORDS

azithromycin
Bacterial Proteins
Drug Resistance, Bacterial
Haemophilus influenzae
BLNAR
azithromycin low susceptibility
AcrR
AcrB

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