DOI: 10.1128/AAC.01337-17
Article Figures & Data
Tables
- TABLE 1
Characteristics and MICs of bacterial strains used in this study
Strain Serotype ST Deletion site in acrR MIC (μg/ml)a CLR CLR + CCCP AZM AZM + CCCP EB 0.75 μg/ml CCCP 1.5 μg/ml CCCP 0.75 μg/ml CCCP 1.5 μg/ml CCCP 2012-42 NTb 156 Nucleotide 141c 32 16 4 8 4 1 ≥16 2011-70 NT 156 Nucleotide 141c 32 16 1 4 1 0.25 8 Rd NT 47 Nonec 8 4 0.25 1 0.5 ≤0.06 1 Rd42acr NT 47 Nucleotide 141c 32 16 2 8 4 0.5 8 Rd70acr NT 47 Nucleotide 141 32 16 1 4 2 0.13 4 - TABLE 2
Detailed MICs of H. influenzae strain Rd and strains with acr mutations
Strain Relative acrB mRNA levela MIC (μg/ml) Ratiob CLR AZM CLR AZM Rd 0.82 ± 0.24 8 1 1 1 Rd42acr 1.86 ± 0.35c 30 8 3.8 8 Rd70acr 1.45 ± 0.09c 26 3.5 3.3 3.5 ↵a The transcription levels were calculated in comparison with the gyrB transcription level. The measurements of acrB transcription levels were performed at least three times on independent occasions.
↵b Ratio of each MIC to that of H. influenzae Rd.
↵c P < 0.05, Rd versus Rd42acr and Rd versus Rd70acr.
Additional Files
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