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Susceptibility

In Vitro Activity of the Novel Pleuromutilin Lefamulin (BC-3781) and Effect of Efflux Pump Inactivation on Multidrug-Resistant and Extensively Drug-Resistant Neisseria gonorrhoeae

Susanne Jacobsson, Susanne Paukner, Daniel Golparian, Jörgen S. Jensen, Magnus Unemo
Susanne Jacobsson
aWHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, National Reference Laboratory for Pathogenic , Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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Susanne Paukner
bNabriva Therapeutics AG, Vienna, Austria
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Daniel Golparian
aWHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, National Reference Laboratory for Pathogenic , Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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Jörgen S. Jensen
cDepartment of Microbiology and Infection Control, Sexually Transmitted Infections, Research and Development, Statens Serum Institut, Copenhagen, Denmark
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  • ORCID record for Jörgen S. Jensen
Magnus Unemo
aWHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, National Reference Laboratory for Pathogenic , Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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DOI: 10.1128/AAC.01497-17
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ABSTRACT

We evaluated the activity of the novel semisynthetic pleuromutilin lefamulin, inhibiting protein synthesis and growth, and the effect of efflux pump inactivation on clinical gonococcal isolates and reference strains (n = 251), including numerous multidrug-resistant and extensively drug-resistant isolates. Lefamulin showed potent activity against all gonococcal isolates, and no significant cross-resistance to other antimicrobials was identified. Further studies of lefamulin are warranted, including in vitro selection and mechanisms of resistance, pharmacokinetics/pharmacodynamics, optimal dosing, and performance in randomized controlled trials.

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In Vitro Activity of the Novel Pleuromutilin Lefamulin (BC-3781) and Effect of Efflux Pump Inactivation on Multidrug-Resistant and Extensively Drug-Resistant Neisseria gonorrhoeae
Susanne Jacobsson, Susanne Paukner, Daniel Golparian, Jörgen S. Jensen, Magnus Unemo
Antimicrobial Agents and Chemotherapy Oct 2017, 61 (11) e01497-17; DOI: 10.1128/AAC.01497-17

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In Vitro Activity of the Novel Pleuromutilin Lefamulin (BC-3781) and Effect of Efflux Pump Inactivation on Multidrug-Resistant and Extensively Drug-Resistant Neisseria gonorrhoeae
Susanne Jacobsson, Susanne Paukner, Daniel Golparian, Jörgen S. Jensen, Magnus Unemo
Antimicrobial Agents and Chemotherapy Oct 2017, 61 (11) e01497-17; DOI: 10.1128/AAC.01497-17
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KEYWORDS

Anti-Bacterial Agents
Diterpenes
Drug Resistance, Multiple, Bacterial
Neisseria gonorrhoeae
Thioglycolates
gonorrhea
pleuromutilin
treatment
antimicrobial resistance
MtrCDE efflux pump

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