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Mechanisms of Resistance

Immunodeficiency and Intermittent Dosing Promote Acquired Rifamycin Monoresistance in Murine Tuberculosis

Sang-Won Park, Rokeya Tasneen, Paul J. Converse, Eric L. Nuermberger
Sang-Won Park
aJohns Hopkins University School of Medicine, Baltimore, Maryland, USA
bSeoul National University College of Medicine and Boramae Medical Center, Seoul, Republic of Korea
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Rokeya Tasneen
aJohns Hopkins University School of Medicine, Baltimore, Maryland, USA
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Paul J. Converse
aJohns Hopkins University School of Medicine, Baltimore, Maryland, USA
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Eric L. Nuermberger
aJohns Hopkins University School of Medicine, Baltimore, Maryland, USA
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DOI: 10.1128/AAC.01502-17
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Article Information

DOI 
https://doi.org/10.1128/AAC.01502-17
PubMed 
28874368

Published By 
American Society for Microbiology Journals
History 
  • Received July 22, 2017
  • Returned for modification August 9, 2017
  • Accepted August 21, 2017
  • Published online October 24, 2017.

Copyright & Usage 
Copyright © 2017 American Society for Microbiology. All Rights Reserved .

Article Versions

  • Accepted Manuscript version (September 05, 2017).
  • You are viewing the most recent version of this article.

Author Information

  1. Sang-Won Parka,b,
  2. Rokeya Tasneena,
  3. Paul J. Conversea and
  4. Eric L. Nuermbergera
  1. aJohns Hopkins University School of Medicine, Baltimore, Maryland, USA
  2. bSeoul National University College of Medicine and Boramae Medical Center, Seoul, Republic of Korea
  • Address correspondence to Eric L. Nuermberger, enuermb{at}jhmi.edu.
  • Citation Park S-W, Tasneen R, Converse PJ, Nuermberger EL. 2017. Immunodeficiency and intermittent dosing promote acquired rifamycin monoresistance in murine tuberculosis. Antimicrob Agents Chemother 61:e01502-17. https://doi.org/10.1128/AAC.01502-17 .

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Immunodeficiency and Intermittent Dosing Promote Acquired Rifamycin Monoresistance in Murine Tuberculosis
Sang-Won Park, Rokeya Tasneen, Paul J. Converse, Eric L. Nuermberger
Antimicrobial Agents and Chemotherapy Oct 2017, 61 (11) e01502-17; DOI: 10.1128/AAC.01502-17

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Immunodeficiency and Intermittent Dosing Promote Acquired Rifamycin Monoresistance in Murine Tuberculosis
Sang-Won Park, Rokeya Tasneen, Paul J. Converse, Eric L. Nuermberger
Antimicrobial Agents and Chemotherapy Oct 2017, 61 (11) e01502-17; DOI: 10.1128/AAC.01502-17
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KEYWORDS

antitubercular agents
Drug Resistance, Bacterial
rifamycins
tuberculosis
acquired rifamycin resistance
nude mouse
tuberculosis
intermittent therapy
immunodeficiency

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