Pharmacokinetic Properties of Micafungin in Critically Ill Patients Diagnosed with Invasive Candidiasis

DOI: 10.1128/AAC.01398-17

Article Figures & Data

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FIG 1
Micafungin concentration-time curves for 19 individual patients during steady state.
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FIG 2
Micafungin exposure expressed as AUC_0–24 correlated with the micafungin trough concentration (in steady state) expressed as C₂₄ (y = 38,127x + 16,601; R² = 0.9766).
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FIG 3
Box-and-whisker plots of the AUC_0–24 of observed values for subjects receiving 100 mg micafungin once daily and predicted values for fixed doses and weight-driven dosing based on the observed values and a linear dosing-exposure relationship (38). (A) Data from ICU patients (n = 19); (B) data from both ICU patients and healthy volunteers (n = 72).

TABLE 1
Patient characteristics
a Rectal carcinoma and trauma.
TABLE 2
Microbiological data
a Three patients had mixed infections with C. albicans and C. glabrata, and 1 patient had a mixed infection with C. albicans, C. glabrata, and C. tropicalis. CVC, central venous catheter.

TABLE 3

Disease severity scores and patient size descriptors correlated with micafungin exposure (AUC)

Parameter^a	Median value (IQR)	Spearman r	P value
APACHE II score	15 (13–19)	0.405	0.085
APACHE IV score	83 (51–107)	0.339	0.156
LODS score	5 (4–7)	0.339	0.156
MODS	4 (2–6)	0.542	0.017
MPMII (%)	55.0 (30.0–66.0)	−0.035	0.886
ODIN score	3 (3–4)	0.301	0.211
SAPS III	55 (38–66)	0.421	0.072
SOFA score	4 (3–9)	0.548	0.015
Body wt (kg)	85 (65–98)	−0.488	0.034
BMI (kg m⁻²)	27.5 (22.7–33.9)	−0.321	0.180
BSA (m²)	2.02 (1.81–2.20)	−0.545	0.016
LBM (kg)	64.1 (50.6–75.9)	−0.485	0.035
FFM (kg)	58.1 (45.3–69.5)	−0.546	0.016

↵a APACHE II, acute physiology and chronic health evaluation II; LODS, logistic organ dysfunction system; MODS, multiple-organ dysfunction score; MPMII, mortality prediction model II; ODIN, organ dysfunctions and/or infection; SAPS III, simplified acute physiology score III; SOFA, sequential organ failure assessment; BMI, body mass index; BSA, body surface area; LBM, lean body mass; FFM, fat-free mass.