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Mechanisms of Resistance

Tigecycline Nonsusceptibility Occurs Exclusively in Fluoroquinolone-Resistant Escherichia coli Clinical Isolates, Including the Major Multidrug-Resistant Lineages O25b:H4-ST131-H30R and O1-ST648

Toyotaka Sato, Yuuki Suzuki, Tsukasa Shiraishi, Hiroyuki Honda, Masaaki Shinagawa, Soh Yamamoto, Noriko Ogasawara, Hiroki Takahashi, Satoshi Takahashi, Yutaka Tamura, Shin-ichi Yokota
Toyotaka Sato
aDepartment of Microbiology, Sapporo Medical University School of Medicine, Sapporo, Japan
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Yuuki Suzuki
aDepartment of Microbiology, Sapporo Medical University School of Medicine, Sapporo, Japan
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Tsukasa Shiraishi
aDepartment of Microbiology, Sapporo Medical University School of Medicine, Sapporo, Japan
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Hiroyuki Honda
aDepartment of Microbiology, Sapporo Medical University School of Medicine, Sapporo, Japan
bDepartment of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Sapporo, Japan
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Masaaki Shinagawa
cDivision of Laboratory Medicine, Sapporo Medical University Hospital, Sapporo, Japan
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Soh Yamamoto
aDepartment of Microbiology, Sapporo Medical University School of Medicine, Sapporo, Japan
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Noriko Ogasawara
aDepartment of Microbiology, Sapporo Medical University School of Medicine, Sapporo, Japan
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Hiroki Takahashi
bDepartment of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Sapporo, Japan
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Satoshi Takahashi
cDivision of Laboratory Medicine, Sapporo Medical University Hospital, Sapporo, Japan
dDepartment of Infection Control and Laboratory Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
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Yutaka Tamura
eLaboratory of Food Microbiology and Food Safety, Department of Health and Environmental Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan
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Shin-ichi Yokota
aDepartment of Microbiology, Sapporo Medical University School of Medicine, Sapporo, Japan
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DOI: 10.1128/AAC.01654-16
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Article Information

DOI 
https://doi.org/10.1128/AAC.01654-16
PubMed 
27855067

Published By 
American Society for Microbiology Journals
History 
  • Received July 29, 2016
  • Returned for modification September 21, 2016
  • Accepted November 8, 2016
  • Published online January 24, 2017.

Copyright & Usage 
Copyright © 2017 American Society for Microbiology. All Rights Reserved .

Article Versions

  • Accepted Manuscript version (November 14, 2016).
  • You are viewing the most recent version of this article.

Author Information

  1. Toyotaka Satoa,
  2. Yuuki Suzukia,
  3. Tsukasa Shiraishia,
  4. Hiroyuki Hondaa,b,
  5. Masaaki Shinagawac,
  6. Soh Yamamotoa,
  7. Noriko Ogasawaraa,
  8. Hiroki Takahashib,
  9. Satoshi Takahashic,d,
  10. Yutaka Tamurae and
  11. Shin-ichi Yokotaa
  1. aDepartment of Microbiology, Sapporo Medical University School of Medicine, Sapporo, Japan
  2. bDepartment of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Sapporo, Japan
  3. cDivision of Laboratory Medicine, Sapporo Medical University Hospital, Sapporo, Japan
  4. dDepartment of Infection Control and Laboratory Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
  5. eLaboratory of Food Microbiology and Food Safety, Department of Health and Environmental Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan
  • Address correspondence to Toyotaka Sato, sato.t{at}sapmed.ac.jp.
  • Citation Sato T, Suzuki Y, Shiraishi T, Honda H, Shinagawa M, Yamamoto S, Ogasawara N, Takahashi H, Takahashi S, Tamura Y, Yokota S. 2017. Tigecycline nonsusceptibility occurs exclusively in fluoroquinolone-resistant Escherichia coli clinical isolates, including the major multidrug-resistant lineages O25b:H4-ST131-H30R and O1-ST648. Antimicrob Agents Chemother 61:e01654-16. https://doi.org/10.1128/AAC.01654-16 .

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Tigecycline Nonsusceptibility Occurs Exclusively in Fluoroquinolone-Resistant Escherichia coli Clinical Isolates, Including the Major Multidrug-Resistant Lineages O25b:H4-ST131-H30R and O1-ST648
Toyotaka Sato, Yuuki Suzuki, Tsukasa Shiraishi, Hiroyuki Honda, Masaaki Shinagawa, Soh Yamamoto, Noriko Ogasawara, Hiroki Takahashi, Satoshi Takahashi, Yutaka Tamura, Shin-ichi Yokota
Antimicrobial Agents and Chemotherapy Jan 2017, 61 (2) e01654-16; DOI: 10.1128/AAC.01654-16

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Tigecycline Nonsusceptibility Occurs Exclusively in Fluoroquinolone-Resistant Escherichia coli Clinical Isolates, Including the Major Multidrug-Resistant Lineages O25b:H4-ST131-H30R and O1-ST648
Toyotaka Sato, Yuuki Suzuki, Tsukasa Shiraishi, Hiroyuki Honda, Masaaki Shinagawa, Soh Yamamoto, Noriko Ogasawara, Hiroki Takahashi, Satoshi Takahashi, Yutaka Tamura, Shin-ichi Yokota
Antimicrobial Agents and Chemotherapy Jan 2017, 61 (2) e01654-16; DOI: 10.1128/AAC.01654-16
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KEYWORDS

Drug Resistance, Multiple, Bacterial
Escherichia coli
fluoroquinolones
minocycline
antimicrobial resistance
bacterial infection
efflux pump

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