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Mechanisms of Resistance

Emergence of Ceftazidime-Avibactam Resistance Due to Plasmid-Borne blaKPC-3 Mutations during Treatment of Carbapenem-Resistant Klebsiella pneumoniae Infections

Ryan K. Shields, Liang Chen, Shaoji Cheng, Kalyan D. Chavda, Ellen G. Press, Avin Snyder, Ruchi Pandey, Yohei Doi, Barry N. Kreiswirth, M. Hong Nguyen, Cornelius J. Clancy
Ryan K. Shields
aDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
bXDR Pathogen Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
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Liang Chen
cPublic Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA
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Shaoji Cheng
aDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
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Kalyan D. Chavda
cPublic Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA
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Ellen G. Press
aDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
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Avin Snyder
aDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
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Ruchi Pandey
cPublic Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA
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Yohei Doi
aDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
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Barry N. Kreiswirth
cPublic Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA
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M. Hong Nguyen
aDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
bXDR Pathogen Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
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Cornelius J. Clancy
aDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
bXDR Pathogen Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
dVA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA
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DOI: 10.1128/AAC.02097-16
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Article Information

DOI 
https://doi.org/10.1128/AAC.02097-16
PubMed 
28031201

Published By 
American Society for Microbiology Journals
History 
  • Received September 28, 2016
  • Returned for modification November 16, 2016
  • Accepted November 18, 2016
  • Published online February 23, 2017.

Copyright & Usage 
Copyright © 2017 American Society for Microbiology. All Rights Reserved .

Article Versions

  • Accepted Manuscript version (December 28, 2016).
  • You are viewing the most recent version of this article.

Author Information

  1. Ryan K. Shieldsa,b,
  2. Liang Chenc,
  3. Shaoji Chenga,
  4. Kalyan D. Chavdac,
  5. Ellen G. Pressa,
  6. Avin Snydera,
  7. Ruchi Pandeyc,
  8. Yohei Doia,
  9. Barry N. Kreiswirthc,
  10. M. Hong Nguyena,b and
  11. Cornelius J. Clancya,b,d
  1. aDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
  2. bXDR Pathogen Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
  3. cPublic Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA
  4. dVA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA
  • Address correspondence to M. Hong Nguyen, mhn5{at}pitt.edu.
  • R.K.S. and L.C. contributed equally to this paper.

  • M.H.N. and C.J.C. contributed equally to this paper.

  • Citation Shields RK, Chen L, Cheng S, Chavda KD, Press EG, Snyder A, Pandey R, Doi Y, Kreiswirth BN, Nguyen MH, Clancy CJ. 2017. Emergence of ceftazidime-avibactam resistance due to plasmid-borne blaKPC-3 mutations during treatment of carbapenem-resistant Klebsiella pneumoniae infections. Antimicrob Agents Chemother 61:e02097-16. https://doi.org/10.1128/AAC.02097-16 .

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Emergence of Ceftazidime-Avibactam Resistance Due to Plasmid-Borne blaKPC-3 Mutations during Treatment of Carbapenem-Resistant Klebsiella pneumoniae Infections
Ryan K. Shields, Liang Chen, Shaoji Cheng, Kalyan D. Chavda, Ellen G. Press, Avin Snyder, Ruchi Pandey, Yohei Doi, Barry N. Kreiswirth, M. Hong Nguyen, Cornelius J. Clancy
Antimicrobial Agents and Chemotherapy Feb 2017, 61 (3) e02097-16; DOI: 10.1128/AAC.02097-16

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Emergence of Ceftazidime-Avibactam Resistance Due to Plasmid-Borne blaKPC-3 Mutations during Treatment of Carbapenem-Resistant Klebsiella pneumoniae Infections
Ryan K. Shields, Liang Chen, Shaoji Cheng, Kalyan D. Chavda, Ellen G. Press, Avin Snyder, Ruchi Pandey, Yohei Doi, Barry N. Kreiswirth, M. Hong Nguyen, Cornelius J. Clancy
Antimicrobial Agents and Chemotherapy Feb 2017, 61 (3) e02097-16; DOI: 10.1128/AAC.02097-16
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KEYWORDS

Anti-Bacterial Agents
Azabicyclo Compounds
Bacterial Proteins
ceftazidime
Genome, Bacterial
Klebsiella Infections
Klebsiella pneumoniae
beta-lactam resistance
beta-lactamases
ceftazidime-avibactam
resistance
carbapenem-resistant Enterobacteriaceae
Klebsiella pneumoniae
Klebsiella pneumoniae carbapenemase
sequence type 258

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