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Pharmacology

New Polymyxin B Dosing Strategies To Fortify Old Allies in the War against KPC-2-Producing Klebsiella pneumoniae

Zackery P. Bulman, Michael J. Satlin, Liang Chen, Barry N. Kreiswirth, Beom Soo Shin, Thomas J. Walsh, Patricia N. Holden, Alan Forrest, Roger L. Nation, Jian Li, Brian T. Tsuji
Zackery P. Bulman
aLaboratory for Antimicrobial Dynamics, NYS Center of Excellence in Bioinformatics & Life Sciences, Buffalo, New York, USA
bSchool of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, USA
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Michael J. Satlin
cWeill Cornell Medical College, Cornell University, New York, New York, USA
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Liang Chen
dPublic Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA
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Barry N. Kreiswirth
dPublic Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA
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Beom Soo Shin
eCatholic University of Daegu, Hayang, South Korea
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Thomas J. Walsh
cWeill Cornell Medical College, Cornell University, New York, New York, USA
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Patricia N. Holden
aLaboratory for Antimicrobial Dynamics, NYS Center of Excellence in Bioinformatics & Life Sciences, Buffalo, New York, USA
bSchool of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, USA
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Alan Forrest
fEshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA
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Roger L. Nation
gDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia
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Jian Li
gDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia
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Brian T. Tsuji
aLaboratory for Antimicrobial Dynamics, NYS Center of Excellence in Bioinformatics & Life Sciences, Buffalo, New York, USA
bSchool of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, USA
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DOI: 10.1128/AAC.02023-16
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Article Information

DOI 
https://doi.org/10.1128/AAC.02023-16
PubMed 
28167549

Published By 
American Society for Microbiology Journals
History 
  • Received September 18, 2016
  • Returned for modification October 23, 2016
  • Accepted January 30, 2017
  • Published online March 24, 2017.

Copyright & Usage 
Copyright © 2017 American Society for Microbiology. All Rights Reserved .

Article Versions

  • Accepted Manuscript version (February 06, 2017).
  • You are viewing the most recent version of this article.

Author Information

  1. Zackery P. Bulmana,b,
  2. Michael J. Satlinc,
  3. Liang Chend,
  4. Barry N. Kreiswirthd,
  5. Beom Soo Shine,
  6. Thomas J. Walshc,
  7. Patricia N. Holdena,b,
  8. Alan Forrestf,
  9. Roger L. Nationg,
  10. Jian Lig and
  11. Brian T. Tsujia,b
  1. aLaboratory for Antimicrobial Dynamics, NYS Center of Excellence in Bioinformatics & Life Sciences, Buffalo, New York, USA
  2. bSchool of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, USA
  3. cWeill Cornell Medical College, Cornell University, New York, New York, USA
  4. dPublic Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA
  5. eCatholic University of Daegu, Hayang, South Korea
  6. fEshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA
  7. gDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia
  • Address correspondence to Brian T. Tsuji, btsuji{at}buffalo.edu.
  • Citation Bulman ZP, Satlin MJ, Chen L, Kreiswirth BN, Shin BS, Walsh TJ, Holden PN, Forrest A, Nation RL, Li J, Tsuji BT. 2017. New polymyxin B dosing strategies to fortify old allies in the war against KPC-2-producing Klebsiella pneumoniae. Antimicrob Agents Chemother 61:e02023-16. https://doi.org/10.1128/AAC.02023-16 .

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New Polymyxin B Dosing Strategies To Fortify Old Allies in the War against KPC-2-Producing Klebsiella pneumoniae
Zackery P. Bulman, Michael J. Satlin, Liang Chen, Barry N. Kreiswirth, Beom Soo Shin, Thomas J. Walsh, Patricia N. Holden, Alan Forrest, Roger L. Nation, Jian Li, Brian T. Tsuji
Antimicrobial Agents and Chemotherapy Mar 2017, 61 (4) e02023-16; DOI: 10.1128/AAC.02023-16

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New Polymyxin B Dosing Strategies To Fortify Old Allies in the War against KPC-2-Producing Klebsiella pneumoniae
Zackery P. Bulman, Michael J. Satlin, Liang Chen, Barry N. Kreiswirth, Beom Soo Shin, Thomas J. Walsh, Patricia N. Holden, Alan Forrest, Roger L. Nation, Jian Li, Brian T. Tsuji
Antimicrobial Agents and Chemotherapy Mar 2017, 61 (4) e02023-16; DOI: 10.1128/AAC.02023-16
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KEYWORDS

Anti-Bacterial Agents
Klebsiella pneumoniae
Models, Statistical
polymyxin B
rifampin
Thienamycins
polymyxin B
meropenem
rifampin
PK/PD
KPC-producing K. pneumoniae

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