DOI: 10.1128/AAC.01174-17
Article Figures & Data
Tables
- TABLE 1
Distribution of penA, ponA, porB1, and mtrR mutations among N. gonorrhoeae isolates in different antibiotic susceptibility groupsa
Mutation and allele or presence/absence No.b (%) of isolates P valueh No.b (%) of isolates P value PEN S PEN I/R CFM S CFM R/DS CRO S CRO R/DS penA Mosaicc 0 (0) 57 (100) 2 (4) 55 (97) <0.001 52 (92) 5 (9) 0.579 Nonmosaic 0 (0) 16 (100) 16 (100) 0 (0) 16 (100) 0 (0) ponA d Yes 0 (0) 63 (100) 8 (13) 55 (87) <0.001 58 (92) 5 (8) 1.000 No 0 (0) 10 (100) 10 (100) 0 (0) 10 (100) 0 (0) porB1 e Yes 0 (0) 50 (100) 5 (10) 45 (90) <0.001 45 (90) 5 (10) 0.173 No 0 (0) 23 (100) 13 (57) 10 (43) 23 (100) 0 (0) mtrR promoterf Yes 0 (0) 46 (100) 6 (13) 40 (87) 0.004 41 (89) 5 (11) 0.150 No 0 (0) 27 (100) 12 (44) 15 (56) 27 (100) 0 (0) mtrR g Yes 0 (0) 30 (100) 12 (40) 18 (60) 0.014 30 (100) 0 (0) 0.074 No 0 (0) 43 (100) 6 (14) 37 (86) 38 (88) 5 (12) ↵a PEN MICs: S, ≤0.06 mg/liter; I, 0.12 to 1 mg/liter; R, ≥2 mg/liter. CFM MICs: S, ≤0.06 mg/liter; DS, 0.125 and 0.25 mg/liter; R, >0.25 mg/liter. CRO MICs: S, ≤0.06 mg/liter; DS, 0.125 and 0.25 mg/liter; R, >0.25 mg/liter.
↵b No. of isolates.
↵c X (including A486V, L353W, and L404S), XXXIV (including P551S), XXVI, and XXVII (including A159V and S172N).
↵d L421P.
↵e G101K and A102D; G101K and A102N; G101 and A102D; G101T and A102D.
↵f Mutations with deletions.
↵g A39T, A40D, and G45D.
↵h For CFM S versus R/DS.
- TABLE 2
Characteristics of N. gonorrhoeae strains with DS to CROa
Strain NG-MAST ST penA mosaic Mutation(s) MIC (mg/liter) ponA porB1 mtrR promoter mtrR PEN CFM CRO KG12041 ST6798 X L421P G101K, A102D A with deletion None 4 0.25 0.125 KG12015 ST6798 X-A486V L421P G101K, A102D A with deletion None 8 0.5 0.125 KG12057 ST6798 X-A486V L421P G101K, A102D A with deletion None 8 0.5 0.125 KG12051 ST14150 XXXIV-P551S L421P G101K, A102N A with deletion None 8 0.5 0.125 KG12014 ST14150 XXXIV-P551S L421P G101K, A102N A with deletion None 8 0.25 0.125 ↵a MIC of >0.064 mg/liter.
