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Susceptibility

Topical Antimicrobial Treatments Can Elicit Shifts to Resident Skin Bacterial Communities and Reduce Colonization by Staphylococcus aureus Competitors

Adam J. SanMiguel, Jacquelyn S. Meisel, Joseph Horwinski, Qi Zheng, Elizabeth A. Grice
Adam J. SanMiguel
Department of Dermatology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA
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Jacquelyn S. Meisel
Department of Dermatology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA
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Joseph Horwinski
Department of Dermatology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA
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Qi Zheng
Department of Dermatology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA
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Elizabeth A. Grice
Department of Dermatology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA
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DOI: 10.1128/AAC.00774-17
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ABSTRACT

The skin microbiome is a complex ecosystem with important implications for cutaneous health and disease. Topical antibiotics and antiseptics are often employed to preserve the balance of this population and inhibit colonization by more pathogenic bacteria. However, despite their widespread use, the impact of these interventions on broader microbial communities remains poorly understood. Here, we report the longitudinal effects of topical antibiotics and antiseptics on skin bacterial communities and their role in Staphylococcus aureus colonization resistance. In response to antibiotics, cutaneous populations exhibited an immediate shift in bacterial residents, an effect that persisted for multiple days posttreatment. By contrast, antiseptics elicited only minor changes to skin bacterial populations, with few changes to the underlying microbiota. While variable in scope, both antibiotics and antiseptics were found to decrease colonization by commensal Staphylococcus spp. by sequencing- and culture-based methods, an effect which was highly dependent on baseline levels of Staphylococcus. Because Staphylococcus residents have been shown to compete with the skin pathogen S. aureus, we also tested whether treatment could influence S. aureus levels at the skin surface. We found that treated mice were more susceptible to exogenous association with S. aureus and that precolonization with the same Staphylococcus residents that were previously disrupted by treatment reduced S. aureus levels by over 100-fold. In all, the results of this study indicate that antimicrobial drugs can alter skin bacterial residents and that these alterations can have critical implications for cutaneous host defense.

FOOTNOTES

    • Received 13 April 2017.
    • Returned for modification 30 May 2017.
    • Accepted 9 June 2017.
    • Accepted manuscript posted online 19 June 2017.
  • Supplemental material for this article may be found at https://doi.org/10.1128/AAC.00774-17 .

  • Copyright © 2017 American Society for Microbiology.

All Rights Reserved .

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Topical Antimicrobial Treatments Can Elicit Shifts to Resident Skin Bacterial Communities and Reduce Colonization by Staphylococcus aureus Competitors
Adam J. SanMiguel, Jacquelyn S. Meisel, Joseph Horwinski, Qi Zheng, Elizabeth A. Grice
Antimicrobial Agents and Chemotherapy Aug 2017, 61 (9) e00774-17; DOI: 10.1128/AAC.00774-17

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Topical Antimicrobial Treatments Can Elicit Shifts to Resident Skin Bacterial Communities and Reduce Colonization by Staphylococcus aureus Competitors
Adam J. SanMiguel, Jacquelyn S. Meisel, Joseph Horwinski, Qi Zheng, Elizabeth A. Grice
Antimicrobial Agents and Chemotherapy Aug 2017, 61 (9) e00774-17; DOI: 10.1128/AAC.00774-17
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KEYWORDS

Anti-Bacterial Agents
skin
Staphylococcal Skin Infections
Staphylococcus aureus
Staphylococcus aureus
antimicrobial agents
skin
microbiome

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