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Pharmacology

Population Pharmacokinetics of the Antimalarial Amodiaquine: a Pooled Analysis To Optimize Dosing

Ali Mohamed Ali, Melissa A. Penny, Thomas A. Smith, Lesley Workman, Philip Sasi, George O. Adjei, Francesca Aweeka, Jean-René Kiechel, Vincent Jullien, Marcus J. Rijken, Rose McGready, Julia Mwesigwa, Kim Kristensen, Kasia Stepniewska, Joel Tarning, Karen I. Barnes, Paolo Denti, for the WWARN Amodiaquine PK Study Group
Ali Mohamed Ali
aSwiss Tropical and Public Health Institute, Basel, Switzerland
bUniversity of Basel, Basel, Switzerland
cIfakara Health Institute, Bagamoyo, Tanzania
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Melissa A. Penny
aSwiss Tropical and Public Health Institute, Basel, Switzerland
bUniversity of Basel, Basel, Switzerland
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Thomas A. Smith
aSwiss Tropical and Public Health Institute, Basel, Switzerland
bUniversity of Basel, Basel, Switzerland
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Lesley Workman
dDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
eWorldWide Antimalarial Resistance Network (WWARN) Clinical Pharmacology and Southern African Regional Hub, University of Cape Town, Cape Town, South Africa
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Philip Sasi
fMuhimbili University of Health and Allied Sciences, Dar-es-Salaam, Tanzania
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George O. Adjei
gCentre for Tropical Clinical Pharmacology and Therapeutics, College of Health Sciences, University of Ghana, Korle Bu, Ghana
hOffice of Research, Innovation and Development, University of Ghana, Legon, Ghana
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Francesca Aweeka
iDepartment of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, California, USA
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Jean-René Kiechel
jDrugs for Neglected Diseases Initiative, Geneva, Switzerland
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Vincent Jullien
kService de Pharmacologie, Hôpital Européen George Pompidou, Université Paris Descartes, Paris, France
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Marcus J. Rijken
lShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand
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Rose McGready
lShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand
mCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
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Julia Mwesigwa
nMedical Research Council Unit, Fajara, the Gambia
oFaculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium
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Kim Kristensen
pDevelopment DMPK-PKPD, Novo Nordisk, Copenhagen, Denmark
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Kasia Stepniewska
mCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
qWorldwide Antimalarial Resistance Network, University of Oxford, Oxford, United Kingdom
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Joel Tarning
mCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
qWorldwide Antimalarial Resistance Network, University of Oxford, Oxford, United Kingdom
rMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
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Karen I. Barnes
dDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
eWorldWide Antimalarial Resistance Network (WWARN) Clinical Pharmacology and Southern African Regional Hub, University of Cape Town, Cape Town, South Africa
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Paolo Denti
dDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
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  • ORCID record for Paolo Denti
DOI: 10.1128/AAC.02193-17
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Article Information

DOI 
https://doi.org/10.1128/AAC.02193-17
PubMed 
30038039

Published By 
American Society for Microbiology Journals
History 
  • Received October 26, 2017
  • Returned for modification December 5, 2017
  • Accepted June 22, 2018
  • Published online September 24, 2018.

Copyright & Usage 
Copyright © 2018 Ali et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

Article Versions

  • Accepted Manuscript version (July 23, 2018).
  • You are viewing the most recent version of this article.

Author Information

  1. Ali Mohamed Alia,b,c,
  2. Melissa A. Pennya,b,
  3. Thomas A. Smitha,b,
  4. Lesley Workmand,e,
  5. Philip Sasif,
  6. George O. Adjeig,h,
  7. Francesca Aweekai,
  8. Jean-René Kiechelj,
  9. Vincent Jullienk,
  10. Marcus J. Rijkenl,
  11. Rose McGreadyl,m,
  12. Julia Mwesigwan,o,
  13. Kim Kristensenp,
  14. Kasia Stepniewskam,q,
  15. Joel Tarningm,q,r,
  16. Karen I. Barnesd,e,
  17. Paolo Dentid,
  18. for the WWARN Amodiaquine PK Study Group
  1. aSwiss Tropical and Public Health Institute, Basel, Switzerland
  2. bUniversity of Basel, Basel, Switzerland
  3. cIfakara Health Institute, Bagamoyo, Tanzania
  4. dDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
  5. eWorldWide Antimalarial Resistance Network (WWARN) Clinical Pharmacology and Southern African Regional Hub, University of Cape Town, Cape Town, South Africa
  6. fMuhimbili University of Health and Allied Sciences, Dar-es-Salaam, Tanzania
  7. gCentre for Tropical Clinical Pharmacology and Therapeutics, College of Health Sciences, University of Ghana, Korle Bu, Ghana
  8. hOffice of Research, Innovation and Development, University of Ghana, Legon, Ghana
  9. iDepartment of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, California, USA
  10. jDrugs for Neglected Diseases Initiative, Geneva, Switzerland
  11. kService de Pharmacologie, Hôpital Européen George Pompidou, Université Paris Descartes, Paris, France
  12. lShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand
  13. mCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
  14. nMedical Research Council Unit, Fajara, the Gambia
  15. oFaculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium
  16. pDevelopment DMPK-PKPD, Novo Nordisk, Copenhagen, Denmark
  17. qWorldwide Antimalarial Resistance Network, University of Oxford, Oxford, United Kingdom
  18. rMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
  • Address correspondence to Paolo Denti, paolo.denti{at}uct.ac.za.
  • Citation Ali AM, Penny MA, Smith TA, Workman L, Sasi P, Adjei GO, Aweeka F, Kiechel J-R, Jullien V, Rijken MJ, McGready R, Mwesigwa J, Kristensen K, Stepniewska K, Tarning J, Barnes KI, Denti P, for the WWARN Amodiaquine PK Study Group. 2018. Population pharmacokinetics of the antimalarial amodiaquine: a pooled analysis to optimize dosing. Antimicrob Agents Chemother 62:e02193-17. https://doi.org/10.1128/AAC.02193-17.

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Population Pharmacokinetics of the Antimalarial Amodiaquine: a Pooled Analysis To Optimize Dosing
Ali Mohamed Ali, Melissa A. Penny, Thomas A. Smith, Lesley Workman, Philip Sasi, George O. Adjei, Francesca Aweeka, Jean-René Kiechel, Vincent Jullien, Marcus J. Rijken, Rose McGready, Julia Mwesigwa, Kim Kristensen, Kasia Stepniewska, Joel Tarning, Karen I. Barnes, Paolo Denti, for the WWARN Amodiaquine PK Study Group
Antimicrobial Agents and Chemotherapy Sep 2018, 62 (10) e02193-17; DOI: 10.1128/AAC.02193-17

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Population Pharmacokinetics of the Antimalarial Amodiaquine: a Pooled Analysis To Optimize Dosing
Ali Mohamed Ali, Melissa A. Penny, Thomas A. Smith, Lesley Workman, Philip Sasi, George O. Adjei, Francesca Aweeka, Jean-René Kiechel, Vincent Jullien, Marcus J. Rijken, Rose McGready, Julia Mwesigwa, Kim Kristensen, Kasia Stepniewska, Joel Tarning, Karen I. Barnes, Paolo Denti, for the WWARN Amodiaquine PK Study Group
Antimicrobial Agents and Chemotherapy Sep 2018, 62 (10) e02193-17; DOI: 10.1128/AAC.02193-17
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    • ABSTRACT
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KEYWORDS

NONMEM
dose optimization
malaria
pediatrics

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