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Antiviral Agents

Nitazoxanide Inhibits Human Norovirus Replication and Synergizes with Ribavirin by Activation of Cellular Antiviral Response

Wen Dang, Lei Xu, Buyun Ma, Sunrui Chen, Yuebang Yin, Kyeong-Ok Chang, Maikel P. Peppelenbosch, Qiuwei Pan
Wen Dang
Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands
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Lei Xu
Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands
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Buyun Ma
Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands
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Sunrui Chen
Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands
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Yuebang Yin
Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands
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Kyeong-Ok Chang
Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA
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Maikel P. Peppelenbosch
Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands
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Qiuwei Pan
Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands
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DOI: 10.1128/AAC.00707-18
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Nitazoxanide Inhibits Human Norovirus Replication and Synergizes with Ribavirin by Activation of Cellular Antiviral Response
Wen Dang, Lei Xu, Buyun Ma, Sunrui Chen, Yuebang Yin, Kyeong-Ok Chang, Maikel P. Peppelenbosch, Qiuwei Pan
Antimicrobial Agents and Chemotherapy Oct 2018, 62 (11) e00707-18; DOI: 10.1128/AAC.00707-18

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Nitazoxanide Inhibits Human Norovirus Replication and Synergizes with Ribavirin by Activation of Cellular Antiviral Response
Wen Dang, Lei Xu, Buyun Ma, Sunrui Chen, Yuebang Yin, Kyeong-Ok Chang, Maikel P. Peppelenbosch, Qiuwei Pan
Antimicrobial Agents and Chemotherapy Oct 2018, 62 (11) e00707-18; DOI: 10.1128/AAC.00707-18
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    • ABSTRACT
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KEYWORDS

nitazoxanide
cell culture model
IRF-1
ribavirin
synergy
noroviruses
tizoxanide

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