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Mechanisms of Action: Physiological Effects

Caspofungin Modulates Ryanodine Receptor-Mediated Calcium Release in Human Cardiac Myocytes

Christian Koch, Jennifer Jersch, Emmanuel Schneck, Fabian Edinger, Hagen Maxeiner, Florian Uhle, Markus A. Weigand, Melanie Markmann, Michael Sander, Michael Henrich
Christian Koch
Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital of Giessen and Marburg, Giessen, Germany
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Jennifer Jersch
Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital of Giessen and Marburg, Giessen, Germany
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Emmanuel Schneck
Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital of Giessen and Marburg, Giessen, Germany
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Fabian Edinger
Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital of Giessen and Marburg, Giessen, Germany
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Hagen Maxeiner
Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital of Giessen and Marburg, Giessen, Germany
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Florian Uhle
Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany
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Markus A. Weigand
Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany
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Melanie Markmann
Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital of Giessen and Marburg, Giessen, Germany
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Michael Sander
Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital of Giessen and Marburg, Giessen, Germany
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Michael Henrich
Department of Anesthesiology, St. Vincentius Clinics, Karlsruhe, Germany
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DOI: 10.1128/AAC.01114-18
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ABSTRACT

Recent studies showed that critically ill patients might be at risk for hemodynamic impairment during caspofungin (CAS) therapy. The aim of our present study was to examine the mechanisms behind CAS-induced cardiac alterations. We revealed a dose-dependent increase in intracellular Ca2+ concentration ([Ca2+]i) after CAS treatment. Ca2+ ions were found to be released from intracellular caffeine-sensitive stores, most probably via the activation of ryanodine receptors.

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Caspofungin Modulates Ryanodine Receptor-Mediated Calcium Release in Human Cardiac Myocytes
Christian Koch, Jennifer Jersch, Emmanuel Schneck, Fabian Edinger, Hagen Maxeiner, Florian Uhle, Markus A. Weigand, Melanie Markmann, Michael Sander, Michael Henrich
Antimicrobial Agents and Chemotherapy Oct 2018, 62 (11) e01114-18; DOI: 10.1128/AAC.01114-18

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Caspofungin Modulates Ryanodine Receptor-Mediated Calcium Release in Human Cardiac Myocytes
Christian Koch, Jennifer Jersch, Emmanuel Schneck, Fabian Edinger, Hagen Maxeiner, Florian Uhle, Markus A. Weigand, Melanie Markmann, Michael Sander, Michael Henrich
Antimicrobial Agents and Chemotherapy Oct 2018, 62 (11) e01114-18; DOI: 10.1128/AAC.01114-18
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KEYWORDS

antifungal agents
adverse drug reaction
cardiac output
cardiac toxicity

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