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Mechanisms of Resistance

Role of Capsule in Resistance to Disinfectants, Host Antimicrobials, and Desiccation in Acinetobacter baumannii

Kyle A. Tipton, Chui-Yoke Chin, Marjan Farokhyfar, David S. Weiss, Philip N. Rather
Kyle A. Tipton
Department of Microbiology and Immunology, Emory University School of Medicine, Emory University, Atlanta, Georgia, USA
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Chui-Yoke Chin
Yerkes National Primate Research Center, Emory University School of Medicine, Emory University, Atlanta, Georgia, USAEmory Antibiotic Resistance Center, Emory University School of Medicine, Emory University, Atlanta, Georgia, USA
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Marjan Farokhyfar
Department of Microbiology and Immunology, Emory University School of Medicine, Emory University, Atlanta, Georgia, USA
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David S. Weiss
Department of Microbiology and Immunology, Emory University School of Medicine, Emory University, Atlanta, Georgia, USAYerkes National Primate Research Center, Emory University School of Medicine, Emory University, Atlanta, Georgia, USAEmory Antibiotic Resistance Center, Emory University School of Medicine, Emory University, Atlanta, Georgia, USAResearch Service, Veterans Affairs, Atlanta VA Medical Center, Decatur, Georgia, USA
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Philip N. Rather
Department of Microbiology and Immunology, Emory University School of Medicine, Emory University, Atlanta, Georgia, USAEmory Antibiotic Resistance Center, Emory University School of Medicine, Emory University, Atlanta, Georgia, USAResearch Service, Veterans Affairs, Atlanta VA Medical Center, Decatur, Georgia, USA
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DOI: 10.1128/AAC.01188-18
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ABSTRACT

Acinetobacter baumannii strain AB5075 forms two cell types distinguished by their opaque (VIR-O) or translucent (AV-T) colonies. VIR-O cells possess a thicker capsule and are more resistant to a variety of stressors than AV-T cells. However, the direct role of the capsule in these stressors was unknown. This study demonstrates that the capsule is required for resistance to disinfectants, lysozyme, and desiccation in Acinetobacter baumannii. In addition, the capsule is required for survival in a mouse lung model of infection.

FOOTNOTES

    • Received 5 June 2018.
    • Returned for modification 22 August 2018.
    • Accepted 25 September 2018.
    • Accepted manuscript posted online 8 October 2018.
  • Supplemental material for this article may be found at https://doi.org/10.1128/AAC.01188-18.

  • Copyright © 2018 American Society for Microbiology.

All Rights Reserved.

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Role of Capsule in Resistance to Disinfectants, Host Antimicrobials, and Desiccation in Acinetobacter baumannii
Kyle A. Tipton, Chui-Yoke Chin, Marjan Farokhyfar, David S. Weiss, Philip N. Rather
Antimicrobial Agents and Chemotherapy Nov 2018, 62 (12) e01188-18; DOI: 10.1128/AAC.01188-18

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Role of Capsule in Resistance to Disinfectants, Host Antimicrobials, and Desiccation in Acinetobacter baumannii
Kyle A. Tipton, Chui-Yoke Chin, Marjan Farokhyfar, David S. Weiss, Philip N. Rather
Antimicrobial Agents and Chemotherapy Nov 2018, 62 (12) e01188-18; DOI: 10.1128/AAC.01188-18
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KEYWORDS

Acinetobacter
capsule
resistance

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