DOI: 10.1128/AAC.01188-18
ABSTRACT
Acinetobacter baumannii strain AB5075 forms two cell types distinguished by their opaque (VIR-O) or translucent (AV-T) colonies. VIR-O cells possess a thicker capsule and are more resistant to a variety of stressors than AV-T cells. However, the direct role of the capsule in these stressors was unknown. This study demonstrates that the capsule is required for resistance to disinfectants, lysozyme, and desiccation in Acinetobacter baumannii. In addition, the capsule is required for survival in a mouse lung model of infection.
FOOTNOTES
- Received 5 June 2018.
- Returned for modification 22 August 2018.
- Accepted 25 September 2018.
- Accepted manuscript posted online 8 October 2018.
Supplemental material for this article may be found at https://doi.org/10.1128/AAC.01188-18.
- Copyright © 2018 American Society for Microbiology.
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