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Antiviral Agents

Identification of Compounds Targeting Hepatitis B Virus Core Protein Dimerization through a Split Luciferase Complementation Assay

Xia-Fei Wei, Chun-Yang Gan, Jing Cui, Ying-Ying Luo, Xue-Fei Cai, Yi Yuan, Jing Shen, Zhi-Ying Li, Wen-Lu Zhang, Quan-Xin Long, Yuan Hu, Juan Chen, Ni Tang, Haitao Guo, Ai-Long Huang, Jie-Li Hu
Xia-Fei Wei
aKey Laboratory of Molecular Biology on Infectious Diseases of the Ministry of Education, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
bCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (CCID), Hangzhou, China
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Chun-Yang Gan
aKey Laboratory of Molecular Biology on Infectious Diseases of the Ministry of Education, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Jing Cui
aKey Laboratory of Molecular Biology on Infectious Diseases of the Ministry of Education, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Ying-Ying Luo
aKey Laboratory of Molecular Biology on Infectious Diseases of the Ministry of Education, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Xue-Fei Cai
aKey Laboratory of Molecular Biology on Infectious Diseases of the Ministry of Education, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Yi Yuan
aKey Laboratory of Molecular Biology on Infectious Diseases of the Ministry of Education, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Jing Shen
aKey Laboratory of Molecular Biology on Infectious Diseases of the Ministry of Education, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Zhi-Ying Li
aKey Laboratory of Molecular Biology on Infectious Diseases of the Ministry of Education, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Wen-Lu Zhang
aKey Laboratory of Molecular Biology on Infectious Diseases of the Ministry of Education, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Quan-Xin Long
aKey Laboratory of Molecular Biology on Infectious Diseases of the Ministry of Education, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Yuan Hu
aKey Laboratory of Molecular Biology on Infectious Diseases of the Ministry of Education, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Juan Chen
aKey Laboratory of Molecular Biology on Infectious Diseases of the Ministry of Education, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Ni Tang
aKey Laboratory of Molecular Biology on Infectious Diseases of the Ministry of Education, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Haitao Guo
cDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA
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Ai-Long Huang
aKey Laboratory of Molecular Biology on Infectious Diseases of the Ministry of Education, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
bCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (CCID), Hangzhou, China
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Jie-Li Hu
aKey Laboratory of Molecular Biology on Infectious Diseases of the Ministry of Education, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
bCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (CCID), Hangzhou, China
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DOI: 10.1128/AAC.01302-18
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Article Information

DOI 
https://doi.org/10.1128/AAC.01302-18
PubMed 
30224531

Published By 
American Society for Microbiology Journals
History 
  • Received June 18, 2018
  • Returned for modification July 3, 2018
  • Accepted September 6, 2018
  • Published online November 26, 2018.

Copyright & Usage 
Copyright © 2018 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (September 17, 2018).
  • You are viewing the most recent version of this article.

Author Information

  1. Xia-Fei Weia,b,
  2. Chun-Yang Gana,
  3. Jing Cuia,
  4. Ying-Ying Luoa,
  5. Xue-Fei Caia,
  6. Yi Yuana,
  7. Jing Shena,
  8. Zhi-Ying Lia,
  9. Wen-Lu Zhanga,
  10. Quan-Xin Longa,
  11. Yuan Hua,
  12. Juan Chena,
  13. Ni Tanga,
  14. Haitao Guoc,
  15. Ai-Long Huanga,b and
  16. Jie-Li Hua,b
  1. aKey Laboratory of Molecular Biology on Infectious Diseases of the Ministry of Education, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
  2. bCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (CCID), Hangzhou, China
  3. cDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA
  • Address correspondence to Ai-Long Huang, ahuang1964{at}163.com, or Jie-Li Hu, hujieli1977{at}163.com.
  • X.-F.W., C.-Y.G., and J.C. contributed equally to this work.

  • Citation Wei X-F, Gan C-Y, Cui J, Luo Y-Y, Cai X-F, Yuan Y, Shen J, Li Z-Y, Zhang W-L, Long Q-X, Hu Y, Chen J, Tang N, Guo H, Huang A-L, Hu J-L. 2018. Identification of compounds targeting hepatitis B virus core protein dimerization through a split luciferase complementation assay. Antimicrob Agents Chemother 62:e01302-18. https://doi.org/10.1128/AAC.01302-18.

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Identification of Compounds Targeting Hepatitis B Virus Core Protein Dimerization through a Split Luciferase Complementation Assay
Xia-Fei Wei, Chun-Yang Gan, Jing Cui, Ying-Ying Luo, Xue-Fei Cai, Yi Yuan, Jing Shen, Zhi-Ying Li, Wen-Lu Zhang, Quan-Xin Long, Yuan Hu, Juan Chen, Ni Tang, Haitao Guo, Ai-Long Huang, Jie-Li Hu
Antimicrobial Agents and Chemotherapy Nov 2018, 62 (12) e01302-18; DOI: 10.1128/AAC.01302-18

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Identification of Compounds Targeting Hepatitis B Virus Core Protein Dimerization through a Split Luciferase Complementation Assay
Xia-Fei Wei, Chun-Yang Gan, Jing Cui, Ying-Ying Luo, Xue-Fei Cai, Yi Yuan, Jing Shen, Zhi-Ying Li, Wen-Lu Zhang, Quan-Xin Long, Yuan Hu, Juan Chen, Ni Tang, Haitao Guo, Ai-Long Huang, Jie-Li Hu
Antimicrobial Agents and Chemotherapy Nov 2018, 62 (12) e01302-18; DOI: 10.1128/AAC.01302-18
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    • ABSTRACT
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KEYWORDS

20-deoxyingenol
Arbidol
hepatitis B virus
cell model
compound screen
core protein
dimer
split luciferase

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