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Experimental Therapeutics

Short Proline-Rich Lipopeptide Potentiates Minocycline and Rifampin against Multidrug- and Extensively Drug-Resistant Pseudomonas aeruginosa

Ronald Domalaon, Yaroslav Sanchak, Linet Cherono Koskei, Yinfeng Lyu, George G. Zhanel, Gilbert Arthur, Frank Schweizer
Ronald Domalaon
aDepartment of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada
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Yaroslav Sanchak
aDepartment of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada
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Linet Cherono Koskei
bDepartment of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada
cSchool of Biological Sciences, University of Nairobi, Nairobi, Kenya
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Yinfeng Lyu
aDepartment of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada
dInstitute of Animal Nutrition, Northeast Agricultural University, Harbin, Heilongjiang, People's Republic of China
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George G. Zhanel
eDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada
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Gilbert Arthur
bDepartment of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada
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Frank Schweizer
aDepartment of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada
eDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada
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  • ORCID record for Frank Schweizer
DOI: 10.1128/AAC.02374-17
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Article Information

DOI 
https://doi.org/10.1128/AAC.02374-17
PubMed 
29437631

Published By 
American Society for Microbiology Journals
History 
  • Received November 20, 2017
  • Returned for modification December 18, 2017
  • Accepted January 27, 2018
  • Published online March 27, 2018.

Copyright & Usage 
Copyright © 2018 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (February 05, 2018).
  • You are viewing the most recent version of this article.

Author Information

  1. Ronald Domalaona,
  2. Yaroslav Sanchaka,
  3. Linet Cherono Koskeib,c,
  4. Yinfeng Lyua,d,
  5. George G. Zhanele,
  6. Gilbert Arthurb and
  7. Frank Schweizera,e
  1. aDepartment of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada
  2. bDepartment of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada
  3. cSchool of Biological Sciences, University of Nairobi, Nairobi, Kenya
  4. dInstitute of Animal Nutrition, Northeast Agricultural University, Harbin, Heilongjiang, People's Republic of China
  5. eDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada
  • Address correspondence to Frank Schweizer, schweize{at}cc.umanitoba.ca.
  • Citation Domalaon R, Sanchak Y, Koskei LC, Lyu Y, Zhanel GG, Arthur G, Schweizer F. 2018. Short proline-rich lipopeptide potentiates minocycline and rifampin against multidrug- and extensively drug-resistant Pseudomonas aeruginosa. Antimicrob Agents Chemother 62:e02374-17. https://doi.org/10.1128/AAC.02374-17.

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Short Proline-Rich Lipopeptide Potentiates Minocycline and Rifampin against Multidrug- and Extensively Drug-Resistant Pseudomonas aeruginosa
Ronald Domalaon, Yaroslav Sanchak, Linet Cherono Koskei, Yinfeng Lyu, George G. Zhanel, Gilbert Arthur, Frank Schweizer
Antimicrobial Agents and Chemotherapy Mar 2018, 62 (4) e02374-17; DOI: 10.1128/AAC.02374-17

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Short Proline-Rich Lipopeptide Potentiates Minocycline and Rifampin against Multidrug- and Extensively Drug-Resistant Pseudomonas aeruginosa
Ronald Domalaon, Yaroslav Sanchak, Linet Cherono Koskei, Yinfeng Lyu, George G. Zhanel, Gilbert Arthur, Frank Schweizer
Antimicrobial Agents and Chemotherapy Mar 2018, 62 (4) e02374-17; DOI: 10.1128/AAC.02374-17
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KEYWORDS

proline-rich antimicrobial peptides
lipopeptides
adjuvant
Pseudomonas aeruginosa
minocycline
rifampin

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