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Experimental Therapeutics

Topical Treatment for Cutaneous Leishmaniasis: Dermato-Pharmacokinetic Lead Optimization of Benzoxaboroles

Katrien Van Bocxlaer, Eric Gaukel, Deirdre Hauser, Seong Hee Park, Sara Schock, Vanessa Yardley, Ryan Randolph, Jacob J. Plattner, Tejal Merchant, Simon L. Croft, Robert T. Jacobs, Stephen A. Wring
Katrien Van Bocxlaer
aLondon School of Hygiene & Tropical Medicine, Faculty of Infections and Tropical Diseases, London, United Kingdom
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Eric Gaukel
bScynexis Inc., Research Triangle Park, North Carolina, USA
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Deirdre Hauser
bScynexis Inc., Research Triangle Park, North Carolina, USA
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Seong Hee Park
bScynexis Inc., Research Triangle Park, North Carolina, USA
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Sara Schock
bScynexis Inc., Research Triangle Park, North Carolina, USA
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Vanessa Yardley
aLondon School of Hygiene & Tropical Medicine, Faculty of Infections and Tropical Diseases, London, United Kingdom
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Ryan Randolph
bScynexis Inc., Research Triangle Park, North Carolina, USA
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Jacob J. Plattner
cAnacor Pharmaceuticals, Inc., Palo Alto, California, USA
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Tejal Merchant
cAnacor Pharmaceuticals, Inc., Palo Alto, California, USA
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Simon L. Croft
aLondon School of Hygiene & Tropical Medicine, Faculty of Infections and Tropical Diseases, London, United Kingdom
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Robert T. Jacobs
cAnacor Pharmaceuticals, Inc., Palo Alto, California, USA
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Stephen A. Wring
bScynexis Inc., Research Triangle Park, North Carolina, USA
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DOI: 10.1128/AAC.02419-17
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Article Information

DOI 
https://doi.org/10.1128/AAC.02419-17
PubMed 
29507073

Published By 
American Society for Microbiology Journals
History 
  • Received November 24, 2017
  • Returned for modification December 30, 2017
  • Accepted February 24, 2018
  • Published online April 26, 2018.

Copyright & Usage 
Copyright © 2018 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (March 05, 2018).
  • You are viewing the most recent version of this article.

Author Information

  1. Katrien Van Bocxlaera,
  2. Eric Gaukelb,
  3. Deirdre Hauserb,
  4. Seong Hee Parkb,
  5. Sara Schockb,
  6. Vanessa Yardleya,
  7. Ryan Randolphb,
  8. Jacob J. Plattnerc,
  9. Tejal Merchantc,
  10. Simon L. Crofta,
  11. Robert T. Jacobsc and
  12. Stephen A. Wringb
  1. aLondon School of Hygiene & Tropical Medicine, Faculty of Infections and Tropical Diseases, London, United Kingdom
  2. bScynexis Inc., Research Triangle Park, North Carolina, USA
  3. cAnacor Pharmaceuticals, Inc., Palo Alto, California, USA
  • Address correspondence to Simon L. Croft, simon.croft{at}lshtm.ac.uk.
  • Citation Van Bocxlaer K, Gaukel E, Hauser D, Park SH, Schock S, Yardley V, Randolph R, Plattner JJ, Merchant T, Croft SL, Jacobs RT, Wring SA. 2018. Topical treatment for cutaneous leishmaniasis: dermato-pharmacokinetic lead optimization of benzoxaboroles. Antimicrob Agents Chemother 62:e02419-17. https://doi.org/10.1128/AAC.02419-17.

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Topical Treatment for Cutaneous Leishmaniasis: Dermato-Pharmacokinetic Lead Optimization of Benzoxaboroles
Katrien Van Bocxlaer, Eric Gaukel, Deirdre Hauser, Seong Hee Park, Sara Schock, Vanessa Yardley, Ryan Randolph, Jacob J. Plattner, Tejal Merchant, Simon L. Croft, Robert T. Jacobs, Stephen A. Wring
Antimicrobial Agents and Chemotherapy Apr 2018, 62 (5) e02419-17; DOI: 10.1128/AAC.02419-17

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Topical Treatment for Cutaneous Leishmaniasis: Dermato-Pharmacokinetic Lead Optimization of Benzoxaboroles
Katrien Van Bocxlaer, Eric Gaukel, Deirdre Hauser, Seong Hee Park, Sara Schock, Vanessa Yardley, Ryan Randolph, Jacob J. Plattner, Tejal Merchant, Simon L. Croft, Robert T. Jacobs, Stephen A. Wring
Antimicrobial Agents and Chemotherapy Apr 2018, 62 (5) e02419-17; DOI: 10.1128/AAC.02419-17
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KEYWORDS

Leishmania
benzoxaboroles
cutaneous leishmaniasis
pharmacokinetics
topical

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