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Experimental Therapeutics

Triclosan Is an Aminoglycoside Adjuvant for Eradication of Pseudomonas aeruginosa Biofilms

Michael M. Maiden, Alessandra M. Agostinho Hunt, Mitchell P. Zachos, Jacob A. Gibson, Martin E. Hurwitz, Martha H. Mulks, Christopher M. Waters
Michael M. Maiden
aDepartments of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA
cThe BEACON Center for The Study of Evolution in Action, Michigan State University, East Lansing, Michigan, USA
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Alessandra M. Agostinho Hunt
aDepartments of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA
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Mitchell P. Zachos
aDepartments of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA
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Jacob A. Gibson
aDepartments of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA
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Martin E. Hurwitz
bDepartment of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan, USA
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Martha H. Mulks
aDepartments of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA
cThe BEACON Center for The Study of Evolution in Action, Michigan State University, East Lansing, Michigan, USA
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Christopher M. Waters
aDepartments of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA
cThe BEACON Center for The Study of Evolution in Action, Michigan State University, East Lansing, Michigan, USA
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DOI: 10.1128/AAC.00146-18
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Article Information

DOI 
https://doi.org/10.1128/AAC.00146-18
PubMed 
29661867

Published By 
American Society for Microbiology Journals
History 
  • Received January 22, 2018
  • Returned for modification February 15, 2018
  • Accepted March 31, 2018
  • Published online May 25, 2018.

Copyright & Usage 
Copyright © 2018 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (April 16, 2018).
  • You are viewing the most recent version of this article.

Author Information

  1. Michael M. Maidena,c,
  2. Alessandra M. Agostinho Hunta,
  3. Mitchell P. Zachosa,
  4. Jacob A. Gibsona*,
  5. Martin E. Hurwitzb,
  6. Martha H. Mulksa,c and
  7. Christopher M. Watersa,c
  1. aDepartments of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA
  2. bDepartment of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan, USA
  3. cThe BEACON Center for The Study of Evolution in Action, Michigan State University, East Lansing, Michigan, USA
  • Address correspondence to Christopher M. Waters, watersc3{at}msu.edu.
  • ↵* Present address: Jacob A. Gibson, Harvard University, Boston, Massachusetts, USA.

  • M.M.M. and A.M.A.H. contributed equally to this work.

  • Citation Maiden MM, Hunt AMA, Zachos MP, Gibson JA, Hurwitz ME, Mulks MH, Waters CM. 2018. Triclosan is an aminoglycoside adjuvant for eradication of Pseudomonas aeruginosa biofilms. Antimicrob Agents Chemother 62:e00146-18. https://doi.org/10.1128/AAC.00146-18.

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Triclosan Is an Aminoglycoside Adjuvant for Eradication of Pseudomonas aeruginosa Biofilms
Michael M. Maiden, Alessandra M. Agostinho Hunt, Mitchell P. Zachos, Jacob A. Gibson, Martin E. Hurwitz, Martha H. Mulks, Christopher M. Waters
Antimicrobial Agents and Chemotherapy May 2018, 62 (6) e00146-18; DOI: 10.1128/AAC.00146-18

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Triclosan Is an Aminoglycoside Adjuvant for Eradication of Pseudomonas aeruginosa Biofilms
Michael M. Maiden, Alessandra M. Agostinho Hunt, Mitchell P. Zachos, Jacob A. Gibson, Martin E. Hurwitz, Martha H. Mulks, Christopher M. Waters
Antimicrobial Agents and Chemotherapy May 2018, 62 (6) e00146-18; DOI: 10.1128/AAC.00146-18
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KEYWORDS

Pseudomonas aeruginosa
biofilm
persister
tobramycin
triclosan

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