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Antiviral Agents

Direct Activation of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by PF-06409577 Inhibits Flavivirus Infection through Modification of Host Cell Lipid Metabolism

Nereida Jiménez de Oya, Ana-Belén Blázquez, Josefina Casas, Juan-Carlos Saiz, Miguel A. Martín-Acebes
Nereida Jiménez de Oya
Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, Spain
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Ana-Belén Blázquez
Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, Spain
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  • ORCID record for Ana-Belén Blázquez
Josefina Casas
Department of Biomedicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CISC), Barcelona, Spain
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Juan-Carlos Saiz
Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, Spain
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Miguel A. Martín-Acebes
Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, Spain
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DOI: 10.1128/AAC.00360-18
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Article Information

DOI 
https://doi.org/10.1128/AAC.00360-18
PubMed 
29712653

Published By 
American Society for Microbiology Journals
History 
  • Received February 21, 2018
  • Returned for modification March 10, 2018
  • Accepted April 21, 2018
  • Published online June 26, 2018.

Copyright & Usage 
Copyright © 2018 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (April 30, 2018).
  • You are viewing the most recent version of this article.

Author Information

  1. Nereida Jiménez de Oyaa,
  2. Ana-Belén Blázqueza,
  3. Josefina Casasb,
  4. Juan-Carlos Saiza and
  5. Miguel A. Martín-Acebesa
  1. aDepartment of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, Spain
  2. bDepartment of Biomedicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CISC), Barcelona, Spain
  • Address correspondence to Miguel A. Martín-Acebes, martin.mangel{at}inia.es.
  • Citation Jiménez de Oya N, Blázquez A-B, Casas J, Saiz J-C, Martín-Acebes MA. 2018. Direct activation of adenosine monophosphate-activated protein kinase (AMPK) by PF-06409577 inhibits flavivirus infection through modification of host cell lipid metabolism. Antimicrob Agents Chemother 62:e00360-18. https://doi.org/10.1128/AAC.00360-18.

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Direct Activation of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by PF-06409577 Inhibits Flavivirus Infection through Modification of Host Cell Lipid Metabolism
Nereida Jiménez de Oya, Ana-Belén Blázquez, Josefina Casas, Juan-Carlos Saiz, Miguel A. Martín-Acebes
Antimicrobial Agents and Chemotherapy Jun 2018, 62 (7) e00360-18; DOI: 10.1128/AAC.00360-18

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Direct Activation of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by PF-06409577 Inhibits Flavivirus Infection through Modification of Host Cell Lipid Metabolism
Nereida Jiménez de Oya, Ana-Belén Blázquez, Josefina Casas, Juan-Carlos Saiz, Miguel A. Martín-Acebes
Antimicrobial Agents and Chemotherapy Jun 2018, 62 (7) e00360-18; DOI: 10.1128/AAC.00360-18
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KEYWORDS

AMPK
West Nile virus
Zika virus
antiviral agents
dengue fever
flavivirus
lipid synthesis

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