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Chemistry; Biosynthesis

Analysis of the Tunicamycin Biosynthetic Gene Cluster of Streptomyces chartreusis Reveals New Insights into Tunicamycin Production and Immunity

David Widdick, Sylvain F. Royer, Hua Wang, Natalia M. Vior, Juan Pablo Gomez-Escribano, Benjamin G. Davis, Mervyn J. Bibb
David Widdick
aDepartment of Molecular Microbiology, John Innes Centre, Norwich Research Park, Norwich, United Kingdom
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Sylvain F. Royer
bDepartment of Chemistry, University of Oxford, Oxford, United Kingdom
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Hua Wang
bDepartment of Chemistry, University of Oxford, Oxford, United Kingdom
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Natalia M. Vior
aDepartment of Molecular Microbiology, John Innes Centre, Norwich Research Park, Norwich, United Kingdom
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Juan Pablo Gomez-Escribano
aDepartment of Molecular Microbiology, John Innes Centre, Norwich Research Park, Norwich, United Kingdom
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Benjamin G. Davis
bDepartment of Chemistry, University of Oxford, Oxford, United Kingdom
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Mervyn J. Bibb
aDepartment of Molecular Microbiology, John Innes Centre, Norwich Research Park, Norwich, United Kingdom
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DOI: 10.1128/AAC.00130-18
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Article Information

DOI 
https://doi.org/10.1128/AAC.00130-18
PubMed 
29844049

Published By 
American Society for Microbiology Journals
History 
  • Received January 26, 2018
  • Returned for modification March 4, 2018
  • Accepted May 10, 2018
  • Published online July 27, 2018.

Copyright & Usage 
Copyright © 2018 Widdick et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

Article Versions

  • Accepted Manuscript version (May 29, 2018).
  • You are viewing the most recent version of this article.

Author Information

  1. David Widdicka,
  2. Sylvain F. Royerb,
  3. Hua Wangb*,
  4. Natalia M. Viora,
  5. Juan Pablo Gomez-Escribanoa,
  6. Benjamin G. Davisb and
  7. Mervyn J. Bibba
  1. aDepartment of Molecular Microbiology, John Innes Centre, Norwich Research Park, Norwich, United Kingdom
  2. bDepartment of Chemistry, University of Oxford, Oxford, United Kingdom
  • Address correspondence to Mervyn J. Bibb, mervyn.bibb{at}jic.ac.uk.
  • ↵* Present address: Hua Wang, The Francis Crick Institute, London, United Kingdom.

  • Citation Widdick D, Royer SF, Wang H, Vior NM, Gomez-Escribano JP, Davis BG, Bibb MJ. 2018. Analysis of the tunicamycin biosynthetic gene cluster of Streptomyces chartreusis reveals new insights into tunicamycin production and immunity. Antimicrob Agents Chemother 62:e00130-18. https://doi.org/10.1128/AAC.00130-18.

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Analysis of the Tunicamycin Biosynthetic Gene Cluster of Streptomyces chartreusis Reveals New Insights into Tunicamycin Production and Immunity
David Widdick, Sylvain F. Royer, Hua Wang, Natalia M. Vior, Juan Pablo Gomez-Escribano, Benjamin G. Davis, Mervyn J. Bibb
Antimicrobial Agents and Chemotherapy Jul 2018, 62 (8) e00130-18; DOI: 10.1128/AAC.00130-18

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Analysis of the Tunicamycin Biosynthetic Gene Cluster of Streptomyces chartreusis Reveals New Insights into Tunicamycin Production and Immunity
David Widdick, Sylvain F. Royer, Hua Wang, Natalia M. Vior, Juan Pablo Gomez-Escribano, Benjamin G. Davis, Mervyn J. Bibb
Antimicrobial Agents and Chemotherapy Jul 2018, 62 (8) e00130-18; DOI: 10.1128/AAC.00130-18
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KEYWORDS

tunicamycin
biosynthesis
immunity
antibiotic
Streptomyces

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