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Experimental Therapeutics

Viability Screen of LOPAC1280 Reveals Phosphorylation Inhibitor Auranofin as a Potent Inhibitor of Blastocystis Subtype 1, 4, and 7 Isolates

John Anthony Yason, Kristine Anne Ru Ping Koh, Kevin Shyong Wei Tan
John Anthony Yason
aLaboratory of Molecular and Cellular Parasitology, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
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Kristine Anne Ru Ping Koh
aLaboratory of Molecular and Cellular Parasitology, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
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Kevin Shyong Wei Tan
aLaboratory of Molecular and Cellular Parasitology, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
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  • ORCID record for Kevin Shyong Wei Tan
DOI: 10.1128/AAC.00208-18
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Article Information

DOI 
https://doi.org/10.1128/AAC.00208-18
PubMed 
29866860

Published By 
American Society for Microbiology Journals
History 
  • Received February 1, 2018
  • Returned for modification March 12, 2018
  • Accepted May 26, 2018
  • Published online July 27, 2018.

Copyright & Usage 
Copyright © 2018 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (June 04, 2018).
  • You are viewing the most recent version of this article.

Author Information

  1. John Anthony Yasona,
  2. Kristine Anne Ru Ping Koha and
  3. Kevin Shyong Wei Tana
  1. aLaboratory of Molecular and Cellular Parasitology, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
  • Address correspondence to Kevin Shyong Wei Tan, mictank{at}nus.edu.sg.
  • Citation Yason JA, Koh KARP, Tan KSW. 2018. Viability screen of LOPAC1280 reveals phosphorylation inhibitor auranofin as a potent inhibitor of Blastocystis subtype 1, 4, and 7 isolates. Antimicrob Agents Chemother 62:e00208-18. https://doi.org/10.1128/AAC.00208-18.

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Viability Screen of LOPAC1280 Reveals Phosphorylation Inhibitor Auranofin as a Potent Inhibitor of Blastocystis Subtype 1, 4, and 7 Isolates
John Anthony Yason, Kristine Anne Ru Ping Koh, Kevin Shyong Wei Tan
Antimicrobial Agents and Chemotherapy Jul 2018, 62 (8) e00208-18; DOI: 10.1128/AAC.00208-18

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Viability Screen of LOPAC1280 Reveals Phosphorylation Inhibitor Auranofin as a Potent Inhibitor of Blastocystis Subtype 1, 4, and 7 Isolates
John Anthony Yason, Kristine Anne Ru Ping Koh, Kevin Shyong Wei Tan
Antimicrobial Agents and Chemotherapy Jul 2018, 62 (8) e00208-18; DOI: 10.1128/AAC.00208-18
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    • ABSTRACT
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KEYWORDS

blastocystis
LOPAC
apoptosis
auranofin
chemotherapy
drug screening
subtype

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