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Mechanisms of Resistance

Molecular Confirmation of the Linkage between the Rhizopus oryzae CYP51A Gene Coding Region and Its Intrinsic Voriconazole and Fluconazole Resistance

Daiana Macedo, Florencia Leonardelli, Catiana Dudiuk, Laura Theill, Matías S. Cabeza, Soledad Gamarra, Guillermo Garcia-Effron
Daiana Macedo
aLaboratorio de Micología y Diagnóstico Molecular, Cátedra de Parasitología y Micología, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
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Florencia Leonardelli
aLaboratorio de Micología y Diagnóstico Molecular, Cátedra de Parasitología y Micología, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
bConsejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), CCT, Santa Fe, Argentina
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Catiana Dudiuk
aLaboratorio de Micología y Diagnóstico Molecular, Cátedra de Parasitología y Micología, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
bConsejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), CCT, Santa Fe, Argentina
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Laura Theill
aLaboratorio de Micología y Diagnóstico Molecular, Cátedra de Parasitología y Micología, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
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Matías S. Cabeza
aLaboratorio de Micología y Diagnóstico Molecular, Cátedra de Parasitología y Micología, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
bConsejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), CCT, Santa Fe, Argentina
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Soledad Gamarra
aLaboratorio de Micología y Diagnóstico Molecular, Cátedra de Parasitología y Micología, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
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Guillermo Garcia-Effron
aLaboratorio de Micología y Diagnóstico Molecular, Cátedra de Parasitología y Micología, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
bConsejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), CCT, Santa Fe, Argentina
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DOI: 10.1128/AAC.00224-18
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Article Information

DOI 
https://doi.org/10.1128/AAC.00224-18
PubMed 
29891608

Published By 
American Society for Microbiology Journals
History 
  • Received February 5, 2018
  • Returned for modification May 7, 2018
  • Accepted May 11, 2018
  • Published online July 27, 2018.

Copyright & Usage 
Copyright © 2018 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (June 11, 2018).
  • You are viewing the most recent version of this article.

Author Information

  1. Daiana Macedoa,
  2. Florencia Leonardellia,b,
  3. Catiana Dudiuka,b,
  4. Laura Theilla,
  5. Matías S. Cabezaa,b,
  6. Soledad Gamarraa and
  7. Guillermo Garcia-Effrona,b
  1. aLaboratorio de Micología y Diagnóstico Molecular, Cátedra de Parasitología y Micología, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
  2. bConsejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), CCT, Santa Fe, Argentina
  • Address correspondence to Guillermo Garcia-Effron, ggarcia{at}unl.edu.ar.
  • Citation Macedo D, Leonardelli F, Dudiuk C, Theill L, Cabeza MS, Gamarra S, Garcia-Effron G. 2018. Molecular confirmation of the linkage between the Rhizopus oryzae CYP51A gene coding region and its intrinsic voriconazole and fluconazole resistance. Antimicrob Agents Chemother 62:e00224-18. https://doi.org/10.1128/AAC.00224-18.

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Molecular Confirmation of the Linkage between the Rhizopus oryzae CYP51A Gene Coding Region and Its Intrinsic Voriconazole and Fluconazole Resistance
Daiana Macedo, Florencia Leonardelli, Catiana Dudiuk, Laura Theill, Matías S. Cabeza, Soledad Gamarra, Guillermo Garcia-Effron
Antimicrobial Agents and Chemotherapy Jul 2018, 62 (8) e00224-18; DOI: 10.1128/AAC.00224-18

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Molecular Confirmation of the Linkage between the Rhizopus oryzae CYP51A Gene Coding Region and Its Intrinsic Voriconazole and Fluconazole Resistance
Daiana Macedo, Florencia Leonardelli, Catiana Dudiuk, Laura Theill, Matías S. Cabeza, Soledad Gamarra, Guillermo Garcia-Effron
Antimicrobial Agents and Chemotherapy Jul 2018, 62 (8) e00224-18; DOI: 10.1128/AAC.00224-18
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KEYWORDS

azole
CYP51
intrinsic resistance
molecular mechanism
resistance
Rhizopus
fluconazole
Mucorales
voriconazole

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