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Mechanisms of Action: Physiological Effects

Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals

Richard J. Wall, Sonia Moniz, Michael G. Thomas, Suzanne Norval, Eun-Jung Ko, Maria Marco, Timothy J. Miles, Ian H. Gilbert, David Horn, Alan H. Fairlamb, Susan Wyllie
Richard J. Wall
aWellcome Trust Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom
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Sonia Moniz
aWellcome Trust Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom
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Michael G. Thomas
aWellcome Trust Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom
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Suzanne Norval
aWellcome Trust Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom
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Eun-Jung Ko
aWellcome Trust Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom
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Maria Marco
bDiseases of the Developing World, GlaxoSmithKline, Madrid, Spain
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Timothy J. Miles
bDiseases of the Developing World, GlaxoSmithKline, Madrid, Spain
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Ian H. Gilbert
aWellcome Trust Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom
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David Horn
aWellcome Trust Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom
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Alan H. Fairlamb
aWellcome Trust Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom
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Susan Wyllie
aWellcome Trust Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom
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DOI: 10.1128/AAC.00235-18
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Article Information

DOI 
https://doi.org/10.1128/AAC.00235-18
PubMed 
29844044

Published By 
American Society for Microbiology Journals
History 
  • Received February 5, 2018
  • Returned for modification March 12, 2018
  • Accepted May 18, 2018
  • Published online July 27, 2018.

Copyright & Usage 
Copyright © 2018 Wall et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

Article Versions

  • Accepted Manuscript version (May 29, 2018).
  • You are viewing the most recent version of this article.

Author Information

  1. Richard J. Walla,
  2. Sonia Moniza,
  3. Michael G. Thomasa,
  4. Suzanne Norvala,
  5. Eun-Jung Koa,
  6. Maria Marcob,
  7. Timothy J. Milesb,
  8. Ian H. Gilberta,
  9. David Horna,
  10. Alan H. Fairlamba and
  11. Susan Wylliea
  1. aWellcome Trust Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom
  2. bDiseases of the Developing World, GlaxoSmithKline, Madrid, Spain
  • Address correspondence to Susan Wyllie, s.wyllie{at}dundee.ac.uk.
  • Citation Wall RJ, Moniz S, Thomas MG, Norval S, Ko E-J, Marco M, Miles TJ, Gilbert IH, Horn D, Fairlamb AH, Wyllie S. 2018. Antitrypanosomal 8-hydroxy-naphthyridines are chelators of divalent transition metals. Antimicrob Agents Chemother 62:e00235-18. https://doi.org/10.1128/AAC.00235-18.

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Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals
Richard J. Wall, Sonia Moniz, Michael G. Thomas, Suzanne Norval, Eun-Jung Ko, Maria Marco, Timothy J. Miles, Ian H. Gilbert, David Horn, Alan H. Fairlamb, Susan Wyllie
Antimicrobial Agents and Chemotherapy Jul 2018, 62 (8) e00235-18; DOI: 10.1128/AAC.00235-18

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Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals
Richard J. Wall, Sonia Moniz, Michael G. Thomas, Suzanne Norval, Eun-Jung Ko, Maria Marco, Timothy J. Miles, Ian H. Gilbert, David Horn, Alan H. Fairlamb, Susan Wyllie
Antimicrobial Agents and Chemotherapy Jul 2018, 62 (8) e00235-18; DOI: 10.1128/AAC.00235-18
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KEYWORDS

chelator
drug discovery
kinetoplastids
mechanisms of action
transition metals

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