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Antiviral Agents

Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus

Angela M. Lam, Christine Espiritu, Robert Vogel, Suping Ren, Vincent Lau, Mollie Kelly, Scott D. Kuduk, George D. Hartman, Osvaldo A. Flores, Klaus Klumpp
Angela M. Lam
Novira Therapeutics, Inc., Spring House, Pennsylvania, USA
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Christine Espiritu
Novira Therapeutics, Inc., Spring House, Pennsylvania, USA
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Robert Vogel
Novira Therapeutics, Inc., Spring House, Pennsylvania, USA
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Suping Ren
Novira Therapeutics, Inc., Spring House, Pennsylvania, USA
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Vincent Lau
Novira Therapeutics, Inc., Spring House, Pennsylvania, USA
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Mollie Kelly
Novira Therapeutics, Inc., Spring House, Pennsylvania, USA
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Scott D. Kuduk
Novira Therapeutics, Inc., Spring House, Pennsylvania, USA
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George D. Hartman
Novira Therapeutics, Inc., Spring House, Pennsylvania, USA
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Osvaldo A. Flores
Novira Therapeutics, Inc., Spring House, Pennsylvania, USA
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Klaus Klumpp
Novira Therapeutics, Inc., Spring House, Pennsylvania, USA
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DOI: 10.1128/AAC.01734-18
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Article Information

DOI 
https://doi.org/10.1128/AAC.01734-18
PubMed 
30373799

Published By 
American Society for Microbiology Journals
History 
  • Received August 17, 2018
  • Returned for modification September 12, 2018
  • Accepted October 18, 2018
  • Published online December 21, 2018.

Copyright & Usage 
Copyright © 2018 Lam et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

Article Versions

  • Accepted Manuscript version (October 29, 2018).
  • You are viewing the most recent version of this article.

Author Information

  1. Angela M. Lama,
  2. Christine Espiritua,
  3. Robert Vogela,
  4. Suping Rena,
  5. Vincent Laua,
  6. Mollie Kellya,
  7. Scott D. Kuduka,
  8. George D. Hartmana,
  9. Osvaldo A. Floresa and
  10. Klaus Klumppa
  1. aNovira Therapeutics, Inc., Spring House, Pennsylvania, USA
  • Address correspondence to Angela M. Lam, alam16{at}its.jnj.com.
  • Citation Lam AM, Espiritu C, Vogel R, Ren S, Lau V, Kelly M, Kuduk SD, Hartman GD, Flores OA, Klumpp K. 2019. Preclinical characterization of NVR 3-778, a first-in-class capsid assembly modulator against hepatitis B virus. Antimicrob Agents Chemother 63:e01734-18. https://doi.org/10.1128/AAC.01734-18.

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Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus
Angela M. Lam, Christine Espiritu, Robert Vogel, Suping Ren, Vincent Lau, Mollie Kelly, Scott D. Kuduk, George D. Hartman, Osvaldo A. Flores, Klaus Klumpp
Antimicrobial Agents and Chemotherapy Dec 2018, 63 (1) e01734-18; DOI: 10.1128/AAC.01734-18

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Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus
Angela M. Lam, Christine Espiritu, Robert Vogel, Suping Ren, Vincent Lau, Mollie Kelly, Scott D. Kuduk, George D. Hartman, Osvaldo A. Flores, Klaus Klumpp
Antimicrobial Agents and Chemotherapy Dec 2018, 63 (1) e01734-18; DOI: 10.1128/AAC.01734-18
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    • ABSTRACT
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KEYWORDS

CHB
HBV inhibitors
capsid assembly modulator
chronic hepatitis B

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