ABSTRACT
The activity of the siderophore cephalosporin cefiderocol is targeted against carbapenem-resistant Gram-negative bacteria. In this study, the activity of cefiderocol against characterized carbapenem-resistant Acinetobacter baumannii complex, Stenotrophomonas maltophilia, Pseudomonas aeruginosa, and Enterobacteriaceae strains was determined by microdilution in iron-depleted Mueller-Hinton broth. The MIC90s against A. baumannii, S. maltophilia, and P. aeruginosa were 1, 0.25, and 0.5 mg/liter, respectively. Against Enterobacteriaceae, the MIC90 was 1 mg/liter for the group harboring OXA-48-like, 2 mg/liter for the group harboring KPC-3, and 8 mg/liter for the group harboring TEM/SHV ESBL, NDM, and KPC-2.
FOOTNOTES
- Received 24 August 2018.
- Returned for modification 8 September 2018.
- Accepted 6 October 2018.
- Accepted manuscript posted online 15 October 2018.
Supplemental material for this article may be found at https://doi.org/10.1128/AAC.01801-18.
- Copyright © 2018 American Society for Microbiology.