ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases

Michael R. Jacobs; Ayman M. Abdelhamed; Caryn E. Good; Daniel D. Rhoads; Kristine M. Hujer; Andrea M. Hujer; T. Nicholas Domitrovic; Susan D. Rudin; Sandra S. Richter; David van Duin; Barry N. Kreiswirth; Chris Greco; Derrick E. Fouts; Robert A. Bonomo

doi:10.1128/AAC.01801-18

Susceptibility

ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases

Michael R. Jacobs, Ayman M. Abdelhamed, Caryn E. Good, Daniel D. Rhoads, Kristine M. Hujer, Andrea M. Hujer, T. Nicholas Domitrovic, Susan D. Rudin, Sandra S. Richter, David van Duin, Barry N. Kreiswirth, Chris Greco, Derrick E. Fouts, Robert A. Bonomo

and for the Antibacterial Resistance Leadership Group (ARLG)

Michael R. Jacobs

Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USADepartment of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ayman M. Abdelhamed

Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USADepartment of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Caryn E. Good

Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USADepartment of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Daniel D. Rhoads

Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USADepartment of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Daniel D. Rhoads

Kristine M. Hujer

Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USALouis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Andrea M. Hujer

Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USALouis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

T. Nicholas Domitrovic

Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USALouis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Susan D. Rudin

Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USALouis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Sandra S. Richter

Department of Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

David van Duin

Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for David van Duin

Barry N. Kreiswirth

Public Health Research Institute, Rutgers New Jersey Medical School, Newark, New Jersey, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Chris Greco

J. Craig Venter Institute, Rockville, Maryland, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Derrick E. Fouts

J. Craig Venter Institute, Rockville, Maryland, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Robert A. Bonomo

Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USALouis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USADepartment of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USADepartment of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USADepartment of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USACenter for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio, USACWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case Virginia, USA CARES), Cleveland, Ohio, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

DOI: 10.1128/AAC.01801-18

Article
Figures & Data
Info & Metrics
PDF

ABSTRACT

The activity of the siderophore cephalosporin cefiderocol is targeted against carbapenem-resistant Gram-negative bacteria. In this study, the activity of cefiderocol against characterized carbapenem-resistant Acinetobacter baumannii complex, Stenotrophomonas maltophilia, Pseudomonas aeruginosa, and Enterobacteriaceae strains was determined by microdilution in iron-depleted Mueller-Hinton broth. The MIC₉₀s against A. baumannii, S. maltophilia, and P. aeruginosa were 1, 0.25, and 0.5 mg/liter, respectively. Against Enterobacteriaceae, the MIC₉₀ was 1 mg/liter for the group harboring OXA-48-like, 2 mg/liter for the group harboring KPC-3, and 8 mg/liter for the group harboring TEM/SHV ESBL, NDM, and KPC-2.

FOOTNOTES

Received 24 August 2018.
Returned for modification 8 September 2018.
Accepted 6 October 2018.
Accepted manuscript posted online 15 October 2018.

Supplemental material for this article may be found at https://doi.org/10.1128/AAC.01801-18.

View Full Text

Log in using your username and password

Username *

Password *

Forgot your user name or password?

Log in through your institution

You may be able to gain access using your login credentials for your institution. Contact your library if you do not have a username and password.

If your organization uses OpenAthens, you can log in using your OpenAthens username and password. To check if your institution is supported, please see this list. Contact your library for more details.

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.

PreviousNext

Download PDF

Citation Tools

ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases

Antimicrobial Agents and Chemotherapy Dec 2018, 63 (1) e01801-18; DOI: 10.1128/AAC.01801-18

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Alerts

User Name *

Password *

Email *

Thank you for sharing this Antimicrobial Agents and Chemotherapy article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases

Message Subject (Your Name) has forwarded a page to you from Antimicrobial Agents and Chemotherapy

Message Body (Your Name) thought you would be interested in this article in Antimicrobial Agents and Chemotherapy.

Your Personal Message