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Susceptibility

ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases

Michael R. Jacobs, Ayman M. Abdelhamed, Caryn E. Good, Daniel D. Rhoads, Kristine M. Hujer, Andrea M. Hujer, T. Nicholas Domitrovic, Susan D. Rudin, Sandra S. Richter, David van Duin, Barry N. Kreiswirth, Chris Greco, Derrick E. Fouts, Robert A. Bonomo
and for the Antibacterial Resistance Leadership Group (ARLG)
Michael R. Jacobs
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USADepartment of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA
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Ayman M. Abdelhamed
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USADepartment of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA
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Caryn E. Good
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USADepartment of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA
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Daniel D. Rhoads
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USADepartment of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA
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  • ORCID record for Daniel D. Rhoads
Kristine M. Hujer
Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USALouis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA
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Andrea M. Hujer
Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USALouis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA
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T. Nicholas Domitrovic
Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USALouis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA
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Susan D. Rudin
Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USALouis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA
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Sandra S. Richter
Department of Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio, USA
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David van Duin
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
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Barry N. Kreiswirth
Public Health Research Institute, Rutgers New Jersey Medical School, Newark, New Jersey, USA
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Chris Greco
J. Craig Venter Institute, Rockville, Maryland, USA
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Derrick E. Fouts
J. Craig Venter Institute, Rockville, Maryland, USA
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Robert A. Bonomo
Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USALouis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USADepartment of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USADepartment of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USADepartment of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USACenter for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio, USACWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case Virginia, USA CARES), Cleveland, Ohio, USA
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DOI: 10.1128/AAC.01801-18
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ABSTRACT

The activity of the siderophore cephalosporin cefiderocol is targeted against carbapenem-resistant Gram-negative bacteria. In this study, the activity of cefiderocol against characterized carbapenem-resistant Acinetobacter baumannii complex, Stenotrophomonas maltophilia, Pseudomonas aeruginosa, and Enterobacteriaceae strains was determined by microdilution in iron-depleted Mueller-Hinton broth. The MIC90s against A. baumannii, S. maltophilia, and P. aeruginosa were 1, 0.25, and 0.5 mg/liter, respectively. Against Enterobacteriaceae, the MIC90 was 1 mg/liter for the group harboring OXA-48-like, 2 mg/liter for the group harboring KPC-3, and 8 mg/liter for the group harboring TEM/SHV ESBL, NDM, and KPC-2.

FOOTNOTES

    • Received 24 August 2018.
    • Returned for modification 8 September 2018.
    • Accepted 6 October 2018.
    • Accepted manuscript posted online 15 October 2018.
  • Supplemental material for this article may be found at https://doi.org/10.1128/AAC.01801-18.

  • Copyright © 2018 American Society for Microbiology.

All Rights Reserved.

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ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases
Michael R. Jacobs, Ayman M. Abdelhamed, Caryn E. Good, Daniel D. Rhoads, Kristine M. Hujer, Andrea M. Hujer, T. Nicholas Domitrovic, Susan D. Rudin, Sandra S. Richter, David van Duin, Barry N. Kreiswirth, Chris Greco, Derrick E. Fouts, Robert A. Bonomo for the Antibacterial Resistance Leadership Group (ARLG)
Antimicrobial Agents and Chemotherapy Dec 2018, 63 (1) e01801-18; DOI: 10.1128/AAC.01801-18

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ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases
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ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases
Michael R. Jacobs, Ayman M. Abdelhamed, Caryn E. Good, Daniel D. Rhoads, Kristine M. Hujer, Andrea M. Hujer, T. Nicholas Domitrovic, Susan D. Rudin, Sandra S. Richter, David van Duin, Barry N. Kreiswirth, Chris Greco, Derrick E. Fouts, Robert A. Bonomo for the Antibacterial Resistance Leadership Group (ARLG)
Antimicrobial Agents and Chemotherapy Dec 2018, 63 (1) e01801-18; DOI: 10.1128/AAC.01801-18
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KEYWORDS

Enterobacteriaceae
Gram-negative bacteria
S-649266
cefiderocol
cephalosporin
siderophore

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