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Mechanisms of Resistance

Role of MurT C-Terminal Domain in the Amidation of Staphylococcus aureus Peptidoglycan

Bárbara V. Gonçalves, Raquel Portela, Ricardo Lobo, Teresa A. Figueiredo, Inês R. Grilo, Ana Madalena Ludovice, Hermínia de Lencastre, Jorge S. Dias, Rita G. Sobral
Bárbara V. Gonçalves
aLaboratory of Molecular Microbiology of Bacterial Pathogens, UCIBIO@REQUIMTE, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal
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Raquel Portela
aLaboratory of Molecular Microbiology of Bacterial Pathogens, UCIBIO@REQUIMTE, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal
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Ricardo Lobo
aLaboratory of Molecular Microbiology of Bacterial Pathogens, UCIBIO@REQUIMTE, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal
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Teresa A. Figueiredo
aLaboratory of Molecular Microbiology of Bacterial Pathogens, UCIBIO@REQUIMTE, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal
bLaboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal
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Inês R. Grilo
aLaboratory of Molecular Microbiology of Bacterial Pathogens, UCIBIO@REQUIMTE, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal
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Ana Madalena Ludovice
aLaboratory of Molecular Microbiology of Bacterial Pathogens, UCIBIO@REQUIMTE, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal
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Hermínia de Lencastre
bLaboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal
dLaboratory of Microbiology and Infectious Diseases, The Rockefeller University, New York, New York, USA
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Jorge S. Dias
c(Bio)Molecular Structure and Interactions by NMR, UCIBIO@REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal
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Rita G. Sobral
aLaboratory of Molecular Microbiology of Bacterial Pathogens, UCIBIO@REQUIMTE, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal
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  • ORCID record for Rita G. Sobral
DOI: 10.1128/AAC.00957-19
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Article Information

DOI 
https://doi.org/10.1128/AAC.00957-19
PubMed 
31358586

Published By 
American Society for Microbiology Journals
History 
  • Received May 9, 2019
  • Returned for modification June 2, 2019
  • Accepted July 20, 2019
  • Published online September 23, 2019.

Copyright & Usage 
Copyright © 2019 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (July 29, 2019).
  • You are viewing the most recent version of this article.

Author Information

  1. Bárbara V. Gonçalvesa,
  2. Raquel Portelaa,
  3. Ricardo Loboa,
  4. Teresa A. Figueiredoa,b,
  5. Inês R. Griloa,
  6. Ana Madalena Ludovicea,
  7. Hermínia de Lencastreb,d,
  8. Jorge S. Diasc and
  9. Rita G. Sobrala
  1. aLaboratory of Molecular Microbiology of Bacterial Pathogens, UCIBIO@REQUIMTE, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal
  2. bLaboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal
  3. c(Bio)Molecular Structure and Interactions by NMR, UCIBIO@REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal
  4. dLaboratory of Microbiology and Infectious Diseases, The Rockefeller University, New York, New York, USA
  • Address correspondence to Rita G. Sobral, rgs{at}fct.unl.pt.
  • B.V.G. and R.P. contributed equally to this article.

  • Citation Gonçalves BV, Portela R, Lobo R, Figueiredo TA, Grilo IR, Ludovice AM, de Lencastre H, Dias JS, Sobral RG. 2019. Role of MurT C-terminal domain in the amidation of Staphylococcus aureus peptidoglycan. Antimicrob Agents Chemother 63:e00957-19. https://doi.org/10.1128/AAC.00957-19.

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Role of MurT C-Terminal Domain in the Amidation of Staphylococcus aureus Peptidoglycan
Bárbara V. Gonçalves, Raquel Portela, Ricardo Lobo, Teresa A. Figueiredo, Inês R. Grilo, Ana Madalena Ludovice, Hermínia de Lencastre, Jorge S. Dias, Rita G. Sobral
Antimicrobial Agents and Chemotherapy Sep 2019, 63 (10) e00957-19; DOI: 10.1128/AAC.00957-19

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Role of MurT C-Terminal Domain in the Amidation of Staphylococcus aureus Peptidoglycan
Bárbara V. Gonçalves, Raquel Portela, Ricardo Lobo, Teresa A. Figueiredo, Inês R. Grilo, Ana Madalena Ludovice, Hermínia de Lencastre, Jorge S. Dias, Rita G. Sobral
Antimicrobial Agents and Chemotherapy Sep 2019, 63 (10) e00957-19; DOI: 10.1128/AAC.00957-19
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KEYWORDS

DUF1727
MurT-GatD
Staphylococcus aureus
antibiotic resistance
cell wall
peptidoglycan amidation

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