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Experimental Therapeutics

High-Dose Rifamycins Enable Shorter Oral Treatment in a Murine Model of Mycobacterium ulcerans Disease

Till F. Omansen, Deepak Almeida, Paul J. Converse, Si-Yang Li, Jin Lee, Ymkje Stienstra, Tjip van der Werf, Jacques H. Grosset, Eric L. Nuermberger
Till F. Omansen
Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USAInfectious Diseases Unit, Department of Internal Medicine, University of Groningen, Groningen, The Netherlands
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Deepak Almeida
Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
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Paul J. Converse
Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
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Si-Yang Li
Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
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Jin Lee
Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
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Ymkje Stienstra
Infectious Diseases Unit, Department of Internal Medicine, University of Groningen, Groningen, The Netherlands
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Tjip van der Werf
Infectious Diseases Unit, Department of Internal Medicine, University of Groningen, Groningen, The NetherlandsDepartment of Pulmonary Diseases and Tuberculosis, University of Groningen, Groningen, The Netherlands
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Jacques H. Grosset
Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
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Eric L. Nuermberger
Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
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DOI: 10.1128/AAC.01478-18
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High-Dose Rifamycins Enable Shorter Oral Treatment in a Murine Model of Mycobacterium ulcerans Disease
Till F. Omansen, Deepak Almeida, Paul J. Converse, Si-Yang Li, Jin Lee, Ymkje Stienstra, Tjip van der Werf, Jacques H. Grosset, Eric L. Nuermberger
Antimicrobial Agents and Chemotherapy Jan 2019, 63 (2) e01478-18; DOI: 10.1128/AAC.01478-18

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High-Dose Rifamycins Enable Shorter Oral Treatment in a Murine Model of Mycobacterium ulcerans Disease
Till F. Omansen, Deepak Almeida, Paul J. Converse, Si-Yang Li, Jin Lee, Ymkje Stienstra, Tjip van der Werf, Jacques H. Grosset, Eric L. Nuermberger
Antimicrobial Agents and Chemotherapy Jan 2019, 63 (2) e01478-18; DOI: 10.1128/AAC.01478-18
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KEYWORDS

Buruli ulcer
Mycobacterium ulcerans
clarithromycin
high-dose rifamycins
rifampin
rifapentine

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