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Experimental Therapeutics

APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in Experimental Coccidioides immitis Pneumonia

Suganya Viriyakosol, Mili Kapoor, Sharon Okamoto, Jonathan Covel, Quinlyn A. Soltow, Michael Trzoss, Karen Joy Shaw, Joshua Fierer
Suganya Viriyakosol
aVA Healthcare, San Diego, California, USA
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Mili Kapoor
bAmplyx Pharmaceuticals, San Diego, California, USA
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Sharon Okamoto
cDivision of Infectious Diseases, Department of Medicine, UC San Diego School of Medicine, San Diego, California, USA
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Jonathan Covel
bAmplyx Pharmaceuticals, San Diego, California, USA
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Quinlyn A. Soltow
bAmplyx Pharmaceuticals, San Diego, California, USA
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Michael Trzoss
bAmplyx Pharmaceuticals, San Diego, California, USA
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Karen Joy Shaw
bAmplyx Pharmaceuticals, San Diego, California, USA
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Joshua Fierer
aVA Healthcare, San Diego, California, USA
bAmplyx Pharmaceuticals, San Diego, California, USA
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DOI: 10.1128/AAC.01715-18
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Article Information

DOI 
https://doi.org/10.1128/AAC.01715-18
PubMed 
30455238

Published By 
American Society for Microbiology Journals
History 
  • Received August 14, 2018
  • Returned for modification October 3, 2018
  • Accepted November 4, 2018
  • Published online January 29, 2019.

Copyright & Usage 
Copyright © 2019 Viriyakosol et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

Article Versions

  • Accepted Manuscript version (November 19, 2018).
  • You are viewing the most recent version of this article.

Author Information

  1. Suganya Viriyakosola,
  2. Mili Kapoorb,
  3. Sharon Okamotoc,
  4. Jonathan Covelb,
  5. Quinlyn A. Soltowb,
  6. Michael Trzossb,
  7. Karen Joy Shawb and
  8. Joshua Fierera,b
  1. aVA Healthcare, San Diego, California, USA
  2. bAmplyx Pharmaceuticals, San Diego, California, USA
  3. cDivision of Infectious Diseases, Department of Medicine, UC San Diego School of Medicine, San Diego, California, USA
  • Address correspondence to Karen Joy Shaw, kshaw{at}amplyx.com, or Joshua Fierer, jfierer{at}ucsd.edu.
  • Citation Viriyakosol S, Kapoor M, Okamoto S, Covel J, Soltow QA, Trzoss M, Shaw KJ, Fierer J. 2019. APX001 and other Gwt1 inhibitor prodrugs are effective in experimental Coccidioides immitis pneumonia. Antimicrob Agents Chemother 63:e01715-18. https://doi.org/10.1128/AAC.01715-18.

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APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in Experimental Coccidioides immitis Pneumonia
Suganya Viriyakosol, Mili Kapoor, Sharon Okamoto, Jonathan Covel, Quinlyn A. Soltow, Michael Trzoss, Karen Joy Shaw, Joshua Fierer
Antimicrobial Agents and Chemotherapy Jan 2019, 63 (2) e01715-18; DOI: 10.1128/AAC.01715-18

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APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in Experimental Coccidioides immitis Pneumonia
Suganya Viriyakosol, Mili Kapoor, Sharon Okamoto, Jonathan Covel, Quinlyn A. Soltow, Michael Trzoss, Karen Joy Shaw, Joshua Fierer
Antimicrobial Agents and Chemotherapy Jan 2019, 63 (2) e01715-18; DOI: 10.1128/AAC.01715-18
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KEYWORDS

1-aminobenzotriazole
APX001
APX001A
Coccidioides
GPI anchor biosynthesis
Gwt1
antifungal therapy

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