Article Figures & Data
Tables
- TABLE 1
Treatment assignment and persistent bacteremia, univariable analyses
Characteristic Treatment assignmenta Bacteremia durationa Combob (n = 90) VAN (n = 66) P value <5 days (n = 103) ≥5 days (n = 53) P value Age (yr, mean ± SD) 58 ± 16 61 ± 17 0.317 58 ± 16 60 ± 17 0.539 Male 50 (55.6) 35 (53.0) 0.871 57 (53.3) 28 (52.8) 0.865 Race/ethnicity 0.417 0.392 Caucasian 55 (61.1) 36 (54.5) 63 (61.2) 28 (52.8) Other 35 (38.9) 30 (45.5) 40 (38.8) 25 (47.2) Diabetes mellitus 43 (47.8) 27 (40.9) 0.419 45 (43.7) 25 (47.2) 0.735 Cancer 16 (17.8) 15 (22.7) 0.543 18 (17.5) 13 (24.5) 0.299 Lung disease 20 (22.2) 10 (15.2) 0.309 17 (16.5) 13 (24.5) 0.284 Congestive heart failure 14 (15.6) 8 (12.1) 0.644 16 (15.5) 6 (11.3) 0.628 End-stage renal disease 27 (30.0) 20 (30.3) >0.999 32 (31.1) 15 (28.3) 0.854 Hemodialysis 15 (16.7) 15 (22.7) 0.412 19 (18.5) 11 (20.8) 0.831 PITT bacteremia score ≥4 19 (12.2) 12 (18.8) 0.690 23 (22.1) 8 (15.4) 0.397 Intensive care unit admission 41 (45.6) 22 (33.3) 0.140 43 (41.8) 20 (37.7) 0.731 Bacteremia source 0.167 0.156 Primary endovascular 27 (30.0) 24 (36.4) 32 (31.1) 19 (35.9) Secondary 50 (55.6) 27 (40.9) 56 (54.4) 21 (39.6) Catheter related 13 (14.4) 15 (22.7) 15 (15.0) 13 (24.5) Prosthesis 14 (15.6) 18 (27.3) 0.107 20 (19.4) 12 (22.6) 0.678 VAN MIC ≤1 mg/liter 74 (82.2) 57 (86.4) 0.517 84 (81.6) 47 (88.6) 0.357 Initial VAN level (mg/liter; median [IQR]) 17.8 (14.0–23.4) 15.7 (11.3–20.2) 0.041 17.5 (14.0–23.0) 15.0 (11.1–23.2) 0.108 VAN therapy duration (days [range]) 12 (8–26) 11.5 (7–22) 0.773 12 (7–31) 13 (9–19) 0.990 Persistent bacteremia 24 (26.7) 29 (43.9) 0.027 In-hospital mortality 14 (15.6) 9 (13.6) 0.822 14 (13.6) 9 (17.0) 0.636 Acute kidney injury 17 (18.9) 5 (7.6) 0.062 13 (12.6) 9 (17.0) 0.474 - TABLE 2
Rates of persistent bacteremia and acute kidney injury by β-lactam class
Characteristic Rate (n [%]) with: Carbapenem (n = 8) Cephalosporin (n = 25) Penicillin (n = 56) Vancomycina (n = 66) Persistent bacteremia 0 (0) 8 (32) 15 (26.8) 29 (43.9) Acute kidney injury 1 (12.5) 4 (16) 12 (21.4) 5 (7.6) ↵a Vancomycin is listed for reference.