DOI: 10.1128/AAC.01865-18
ABSTRACT
This study characterized the pharmacokinetics of novel 100-mg levofloxacin dispersible tablets in 24 children aged <5 years who had household multidrug-resistant tuberculosus (MDR-TB) exposure. The current data were pooled with previously published data from children (n = 109) with MDR-TB receiving adult (250-mg) levofloxacin tablets, using nonlinear mixed-effects modelling. The adult tablets had 41% lower bioavailability than the novel dispersible tablets, resulting in much higher exposures with the dispersible tablets with the same dose.
FOOTNOTES
- Received 30 August 2018.
- Returned for modification 25 October 2018.
- Accepted 3 January 2019.
- Accepted manuscript posted online 22 January 2019.
Supplemental material for this article may be found at https://doi.org/10.1128/AAC.01865-18.
- Copyright © 2019 American Society for Microbiology.
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