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Experimental Therapeutics

In Vitro Antimicrobial Activity of Diacerein on 76 Isolates of Gram-Positive Cocci from Bacterial Keratitis Patients and In Vivo Study of Diacerein Eye Drops on Staphylococcus aureus Keratitis in Mice

Hongmin Zhang, Susu Liu, Juan Yue, Shengtao Sun, Qixue Lv, Shoujun Jian, Yanting Xie, Lei Han, Fenfen Zhang, Yanfang Dai, Liya Wang
Hongmin Zhang
aHenan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, China
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  • ORCID record for Hongmin Zhang
Susu Liu
aHenan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, China
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Juan Yue
aHenan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, China
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Shengtao Sun
aHenan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, China
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Qixue Lv
aHenan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, China
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Shoujun Jian
aHenan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, China
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Yanting Xie
aHenan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, China
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Lei Han
aHenan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, China
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Fenfen Zhang
bHenan People's Hospital, Jinzhou Medical University, Zhengzhou, China
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Yanfang Dai
aHenan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, China
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Liya Wang
aHenan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, China
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DOI: 10.1128/AAC.01874-18
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Article Information

DOI 
https://doi.org/10.1128/AAC.01874-18
PubMed 
30718254

Published By 
American Society for Microbiology Journals
History 
  • Received September 11, 2018
  • Returned for modification October 10, 2018
  • Accepted January 25, 2019
  • Published online March 27, 2019.

Copyright & Usage 
Copyright © 2019 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (February 04, 2019).
  • You are viewing the most recent version of this article.

Author Information

  1. Hongmin Zhanga,
  2. Susu Liua,
  3. Juan Yuea,
  4. Shengtao Suna,
  5. Qixue Lva,
  6. Shoujun Jiana,
  7. Yanting Xiea,
  8. Lei Hana,
  9. Fenfen Zhangb,
  10. Yanfang Daia and
  11. Liya Wanga
  1. aHenan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, China
  2. bHenan People's Hospital, Jinzhou Medical University, Zhengzhou, China
  • Address correspondence to Hongmin Zhang, zhm0906{at}163.com, or Liya Wang, wangliya_55{at}126.com.
  • H.Z. and S.L. contributed equally to this work.

  • Citation Zhang H, Liu S, Yue J, Sun S, Lv Q, Jian S, Xie Y, Han L, Zhang F, Dai Y, Wang L. 2019. In vitro antimicrobial activity of diacerein on 76 isolates of Gram-positive cocci from bacterial keratitis patients and in vivo study of diacerein eye drops on Staphylococcus aureus keratitis in mice. Antimicrob Agents Chemother 63:e01874-18. https://doi.org/10.1128/AAC.01874-18.

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In Vitro Antimicrobial Activity of Diacerein on 76 Isolates of Gram-Positive Cocci from Bacterial Keratitis Patients and In Vivo Study of Diacerein Eye Drops on Staphylococcus aureus Keratitis in Mice
Hongmin Zhang, Susu Liu, Juan Yue, Shengtao Sun, Qixue Lv, Shoujun Jian, Yanting Xie, Lei Han, Fenfen Zhang, Yanfang Dai, Liya Wang
Antimicrobial Agents and Chemotherapy Mar 2019, 63 (4) e01874-18; DOI: 10.1128/AAC.01874-18

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In Vitro Antimicrobial Activity of Diacerein on 76 Isolates of Gram-Positive Cocci from Bacterial Keratitis Patients and In Vivo Study of Diacerein Eye Drops on Staphylococcus aureus Keratitis in Mice
Hongmin Zhang, Susu Liu, Juan Yue, Shengtao Sun, Qixue Lv, Shoujun Jian, Yanting Xie, Lei Han, Fenfen Zhang, Yanfang Dai, Liya Wang
Antimicrobial Agents and Chemotherapy Mar 2019, 63 (4) e01874-18; DOI: 10.1128/AAC.01874-18
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KEYWORDS

Enterococcus
Gram-positive cocci
Staphylococcus aureus
bacterial keratitis
diacerein eye drop

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